Comparison of morphine with fentanyl added to intrathecal 0.5% hyperbaric bupivacaine for analgesia after caesarean section

G. Siti Salmah, Yin Choy Choy

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    This was a prospective randomised, controlled, single-blind study done to determine the effect of intrathecal morphine 0.1 mg as compared with intrathecal fentanyl 25 μg in terms of analgesia and duration for postoperative pain relief after Caesarean section. Sixty ASA I or II parturients were randomised into two groups. Group 1 (n=33) received 1.8ml of 0.5% hyperbaric bupivacaine combined with 0.1mg morphine while Group 2 (n=27) received 1.8ml of 0.5% hyperbaric bupivacaine combined with 25μg fentanyl for spinal anaesthesia. Postoperatively, all patients were provided with patient controlled analgesia (PCA) morphine. Pain was assessed using visual analogue score (VAS) at 6, 12, 18 and 24 hours. Time to first demand of PCA morphine, cumulative PCA morphine requirement and opioid side effects were documented. The VAS for pain and the cumulative PCA morphine requirement were both significantly lower in Group 1 (p<0.05) during the 24 hours study period. The time to first demand was also significantly longer in Group 1 (p<0.05). Overall, there were no significant difference between the two groups in side effects, except for a high incidence of nausea and vomiting requiring treatment in Group B in the first six hours. In conclusion the addition of 0.1mg morphine for spinal anaesthesia provided superior and longer postoperative analgesia after Caesarean section.

    Original languageEnglish
    Pages (from-to)71-74
    Number of pages4
    JournalMedical Journal of Malaysia
    Volume64
    Issue number1
    Publication statusPublished - Mar 2009

    Fingerprint

    Bupivacaine
    Fentanyl
    Cesarean Section
    Analgesia
    Morphine
    Patient-Controlled Analgesia
    Spinal Anesthesia
    Single-Blind Method
    Pain
    Postoperative Pain
    Nausea
    Opioid Analgesics
    Vomiting
    Parturition
    Incidence

    Keywords

    • Caesarean section
    • Intrathecal fentanyl
    • Intrathecal morphine
    • Postoperative analgesia

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Comparison of morphine with fentanyl added to intrathecal 0.5% hyperbaric bupivacaine for analgesia after caesarean section. / Salmah, G. Siti; Choy, Yin Choy.

    In: Medical Journal of Malaysia, Vol. 64, No. 1, 03.2009, p. 71-74.

    Research output: Contribution to journalArticle

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