Comparison of morbidities in very low birthweight and normal birthweight infants during the first year of life in a developing country

N. Y. Boo, L. C. Ong, M. S. Lye, V. Chandran, S. L. Teoh, Siti Zamratol Mai Sarah Mukari, M. K. Nyein, L. Allison

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To compare the morbidities in the very low birthweight (VLBW; <1500 g) and normal birthweight (NBW; ≤2500 g) Malaysian infants during the first year of life. Methodology: Prospective observational cohort study of consecutive surviving VLBW infants and randomly sampled NEW infants born in the Kuala Lumpur Maternity Hospital between 1 December 1989 and 31 December 1992. Infants were followed up regularly during the first year of life, after correction for prematurity. Results: Compared with NBW infants (n = 106), VLBW infants (n = 127) had significantly higher risk of failure to thrive (odds ratio [OR] = 8.0, 95% confidence intervals [Cl]: 1.1 to 354.3), wheezing (OR = 3.7, 95% Cl: 1.6 to 9.3), rehospitalization (OR = 2.3, 95% Cl: 1.1 to 5.0), cerebral palsy (OR = 8.6, 95% Cl: 2.0 to 77.6), neurosensory hearing loss (OR = 12.0, 95% Cl: 1.7 to 513.6) and visual loss (7.9 vs 0%, P = 0.002). The mean mental developmental index (MDI) and mean psychomotor developmental index (PDI) at 1 year of age were significantly lower among VLBW infants (MDI 99 [SD = 28], PDI 89 [SD = 25]) than NEW infants (MDI 106 [SD = 18], PDI 101 [SD = 18]) (95% Cl for difference between means being MDI: -14.1 to -1.7; and PDI: -17.6 to -6.0). Logistic regression analysis showed that among VLBW infants: (i) male sex, Malay ethnicity and bronchopulmonary dysplasia were significant risk factors associated with wheezing; (ii) longer duration of oxygen therapy during the neonatal period, seizures after the post-neonatal period and wheezing were significant risk factors associated with rehospitalization; and (iii) longer duration of oxygen therapy during the neonatal period was a significant risk factor associated with adverse neurodevelopmental outcome during the first year of life. Conclusions: Compared with NEW infants, VLBW Malaysian infants had significantly higher risks of physical and neurodevelopmental morbidities.

Original languageEnglish
Pages (from-to)439-444
Number of pages6
JournalJournal of Paediatrics and Child Health
Volume32
Issue number5
Publication statusPublished - 1996

Fingerprint

Developing Countries
Morbidity
Odds Ratio
Respiratory Sounds
Oxygen
Maternity Hospitals
Failure to Thrive
Bronchopulmonary Dysplasia
Cerebral Palsy
Hearing Loss
Observational Studies
Seizures
Cohort Studies
Logistic Models
Regression Analysis
Confidence Intervals
Therapeutics

Keywords

  • First year of life
  • Infancy
  • Morbidity
  • Very low birthweight infants

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Boo, N. Y., Ong, L. C., Lye, M. S., Chandran, V., Teoh, S. L., Mukari, S. Z. M. S., ... Allison, L. (1996). Comparison of morbidities in very low birthweight and normal birthweight infants during the first year of life in a developing country. Journal of Paediatrics and Child Health, 32(5), 439-444.

Comparison of morbidities in very low birthweight and normal birthweight infants during the first year of life in a developing country. / Boo, N. Y.; Ong, L. C.; Lye, M. S.; Chandran, V.; Teoh, S. L.; Mukari, Siti Zamratol Mai Sarah; Nyein, M. K.; Allison, L.

In: Journal of Paediatrics and Child Health, Vol. 32, No. 5, 1996, p. 439-444.

Research output: Contribution to journalArticle

Boo, NY, Ong, LC, Lye, MS, Chandran, V, Teoh, SL, Mukari, SZMS, Nyein, MK & Allison, L 1996, 'Comparison of morbidities in very low birthweight and normal birthweight infants during the first year of life in a developing country', Journal of Paediatrics and Child Health, vol. 32, no. 5, pp. 439-444.
Boo, N. Y. ; Ong, L. C. ; Lye, M. S. ; Chandran, V. ; Teoh, S. L. ; Mukari, Siti Zamratol Mai Sarah ; Nyein, M. K. ; Allison, L. / Comparison of morbidities in very low birthweight and normal birthweight infants during the first year of life in a developing country. In: Journal of Paediatrics and Child Health. 1996 ; Vol. 32, No. 5. pp. 439-444.
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AU - Ong, L. C.

AU - Lye, M. S.

AU - Chandran, V.

AU - Teoh, S. L.

AU - Mukari, Siti Zamratol Mai Sarah

AU - Nyein, M. K.

AU - Allison, L.

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N2 - Objective: To compare the morbidities in the very low birthweight (VLBW; <1500 g) and normal birthweight (NBW; ≤2500 g) Malaysian infants during the first year of life. Methodology: Prospective observational cohort study of consecutive surviving VLBW infants and randomly sampled NEW infants born in the Kuala Lumpur Maternity Hospital between 1 December 1989 and 31 December 1992. Infants were followed up regularly during the first year of life, after correction for prematurity. Results: Compared with NBW infants (n = 106), VLBW infants (n = 127) had significantly higher risk of failure to thrive (odds ratio [OR] = 8.0, 95% confidence intervals [Cl]: 1.1 to 354.3), wheezing (OR = 3.7, 95% Cl: 1.6 to 9.3), rehospitalization (OR = 2.3, 95% Cl: 1.1 to 5.0), cerebral palsy (OR = 8.6, 95% Cl: 2.0 to 77.6), neurosensory hearing loss (OR = 12.0, 95% Cl: 1.7 to 513.6) and visual loss (7.9 vs 0%, P = 0.002). The mean mental developmental index (MDI) and mean psychomotor developmental index (PDI) at 1 year of age were significantly lower among VLBW infants (MDI 99 [SD = 28], PDI 89 [SD = 25]) than NEW infants (MDI 106 [SD = 18], PDI 101 [SD = 18]) (95% Cl for difference between means being MDI: -14.1 to -1.7; and PDI: -17.6 to -6.0). Logistic regression analysis showed that among VLBW infants: (i) male sex, Malay ethnicity and bronchopulmonary dysplasia were significant risk factors associated with wheezing; (ii) longer duration of oxygen therapy during the neonatal period, seizures after the post-neonatal period and wheezing were significant risk factors associated with rehospitalization; and (iii) longer duration of oxygen therapy during the neonatal period was a significant risk factor associated with adverse neurodevelopmental outcome during the first year of life. Conclusions: Compared with NEW infants, VLBW Malaysian infants had significantly higher risks of physical and neurodevelopmental morbidities.

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