Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines

Waleed M. Hussein, Saori Mukaida, Fazren Azmi, Stacey Bartlett, Celine Olivier, Michael R. Batzloff, Michael F. Good, Mariusz Skwarczynski, Istvan Toth

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund’s adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalACS Medicinal Chemistry Letters
Volume8
Issue number2
DOIs
Publication statusPublished - 9 Feb 2017

Fingerprint

Subunit Vaccines
Humoral Immunity
Vaccines
Lipids
Immunologic Adjuvants
Peptide Library
Fluorination
Peptides
Freund's Adjuvant
Halogenation
Streptococcus
Immunoglobulin G
Antigens

Keywords

  • cellular immunity
  • Fluorinated lipid
  • humoral immunity
  • nanoparticle
  • peptide-based vaccine
  • self-adjuvant

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines. / Hussein, Waleed M.; Mukaida, Saori; Azmi, Fazren; Bartlett, Stacey; Olivier, Celine; Batzloff, Michael R.; Good, Michael F.; Skwarczynski, Mariusz; Toth, Istvan.

In: ACS Medicinal Chemistry Letters, Vol. 8, No. 2, 09.02.2017, p. 227-232.

Research output: Contribution to journalArticle

Hussein, WM, Mukaida, S, Azmi, F, Bartlett, S, Olivier, C, Batzloff, MR, Good, MF, Skwarczynski, M & Toth, I 2017, 'Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines', ACS Medicinal Chemistry Letters, vol. 8, no. 2, pp. 227-232. https://doi.org/10.1021/acsmedchemlett.6b00453
Hussein, Waleed M. ; Mukaida, Saori ; Azmi, Fazren ; Bartlett, Stacey ; Olivier, Celine ; Batzloff, Michael R. ; Good, Michael F. ; Skwarczynski, Mariusz ; Toth, Istvan. / Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines. In: ACS Medicinal Chemistry Letters. 2017 ; Vol. 8, No. 2. pp. 227-232.
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