Comparison of dexmedetomidine, pethidine and tramadol in the treatment of post-neuraxial anaesthesia shivering

Lim Fern, Karis Misiran

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: This study was performed to compare the effectiveness of intravenous dexmedetomidine with that of pethidine and tramadol in the treatment of post-neuraxial anaesthesia shivering. Design: This was a prospective, randomised, double-blinded study. Setting and subjects: One hundred and two patients of both genders, aged 18–70 years with American Society of Anesthesiologists physical status I and II undergoing spinal or combined spinal and epidural anaesthesia for elective surgery were enrolled in this study. Sixty of them developed shivering after an intrathecal injection of 0.5% hyperbaric bupivacaine 15 mg. They were then randomly allocated to receive either intravenous dexmedetomidine 0.5 μg/kg, pethidine 0.5 mg/kg or tramadol 0.5 mg/kg. Outcome measures: The response rate to treatment, the degree of sedation and the side-effects were recorded. Results: The response rate to treatment was highest in the dexmedetomidine group, and it was only significant when compared to tramadol group (p = 0.0012). It was noted that the response rate was higher in the pethidine than in the tramadol group. This difference was not statistically significant (p = 0.082). The sedation score post treatment was similar in all three groups, but more patients in the dexmedetomidine group developed hypotension and bradycardia (p < 0.05). Conclusion: Dexmedetomidine 0.5 μg/ml was more effective than tramadol 0.5 mg/ml and pethidine 0.5 mg/ml, and both tramadol and pethidine were found to have similar efficacy, in the treatment of post-neuraxial anaesthesia shivering. However, dexmedetomidine caused a higher incidence of hypotension and bradycardia.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalSouthern African Journal of Anaesthesia and Analgesia
Volume21
Issue number1
DOIs
Publication statusPublished - 2015
Externally publishedYes

Fingerprint

Dexmedetomidine
Shivering
Tramadol
Meperidine
Anesthesia
Bradycardia
Hypotension
Therapeutics
Spinal Injections
Epidural Anesthesia
Spinal Anesthesia
Bupivacaine
Outcome Assessment (Health Care)
Incidence

Keywords

  • Dexmedetomidine
  • Pethidine
  • Post-neuraxial anaesthesia shivering
  • Tramadol

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Comparison of dexmedetomidine, pethidine and tramadol in the treatment of post-neuraxial anaesthesia shivering. / Fern, Lim; Misiran, Karis.

In: Southern African Journal of Anaesthesia and Analgesia, Vol. 21, No. 1, 2015, p. 21-26.

Research output: Contribution to journalArticle

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abstract = "Objective: This study was performed to compare the effectiveness of intravenous dexmedetomidine with that of pethidine and tramadol in the treatment of post-neuraxial anaesthesia shivering. Design: This was a prospective, randomised, double-blinded study. Setting and subjects: One hundred and two patients of both genders, aged 18–70 years with American Society of Anesthesiologists physical status I and II undergoing spinal or combined spinal and epidural anaesthesia for elective surgery were enrolled in this study. Sixty of them developed shivering after an intrathecal injection of 0.5{\%} hyperbaric bupivacaine 15 mg. They were then randomly allocated to receive either intravenous dexmedetomidine 0.5 μg/kg, pethidine 0.5 mg/kg or tramadol 0.5 mg/kg. Outcome measures: The response rate to treatment, the degree of sedation and the side-effects were recorded. Results: The response rate to treatment was highest in the dexmedetomidine group, and it was only significant when compared to tramadol group (p = 0.0012). It was noted that the response rate was higher in the pethidine than in the tramadol group. This difference was not statistically significant (p = 0.082). The sedation score post treatment was similar in all three groups, but more patients in the dexmedetomidine group developed hypotension and bradycardia (p < 0.05). Conclusion: Dexmedetomidine 0.5 μg/ml was more effective than tramadol 0.5 mg/ml and pethidine 0.5 mg/ml, and both tramadol and pethidine were found to have similar efficacy, in the treatment of post-neuraxial anaesthesia shivering. However, dexmedetomidine caused a higher incidence of hypotension and bradycardia.",
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