Comparison of Chlorella vulgaris dressing and sodium alginate dressing: An experimental study in rats

N. Zailan, Abdul Halim Abd Rashid, Srijit Das, N. A. Abdul Mokti, J. Hassan Basri, Seong Lin Teoh, W. Z. Wan Ngah, Yasmin Anum Mohd Yusof

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and Aims: Chlorella vulgaris (CV) is a green microalgae enriched with nutrients, vitamins, minerals and chlorophyll. The aim of our study was to evaluate the potential wound healing effects of CV as a dressing while comparing it to sodium alginate dressing. Materials and methods: Fifteen Sprague-Dawley rats were divided into three groups consisting of control (normal-wound with no dressing), CV and sodium alginate dressings. Wound was created on the dorsal surface of rats using a 6-mm sterilized punch biopsy. The wounds were examined on days 3, 6, 9 and 12 for dryness, exudation, contraction, period of epithelialization, complete wound closure and scar formation. All rats were sacrificed on day 12 and the granulation tissue formed on the wound was excised for the histological examination using Hematoxylin and Eosin stain (H&E). Results: The wound's size treated with CV dressing was significantly reduced (p<0.05) compared to the control and sodium alginate treated wounds. H&E staining showed that CV dressing minimized the formation of scar tissue during the healing process. Although there was no statistically significant difference in the complete wound closure and period of epithelialization among the groups, a significant difference was observed regarding the dryness, exudation and scar formation in the wound. Conclusion: CV extract can be used as an effective supplement for wound dressing.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalClinica Terapeutica
Volume161
Issue number6
Publication statusPublished - 2010

Fingerprint

Chlorella vulgaris
Bandages
Wounds and Injuries
Cicatrix
Re-Epithelialization
Microalgae
alginic acid
Granulation Tissue
Hematoxylin
Chlorophyll
Eosine Yellowish-(YS)
Vitamins
Wound Healing
Minerals
Sprague Dawley Rats
Coloring Agents
Staining and Labeling

Keywords

  • Chlorella vulgaris
  • Dressing
  • Granulation
  • Healing
  • Scar scar
  • Sodium alginate
  • Tissue
  • Wound

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparison of Chlorella vulgaris dressing and sodium alginate dressing : An experimental study in rats. / Zailan, N.; Abd Rashid, Abdul Halim; Das, Srijit; Abdul Mokti, N. A.; Hassan Basri, J.; Teoh, Seong Lin; Wan Ngah, W. Z.; Mohd Yusof, Yasmin Anum.

In: Clinica Terapeutica, Vol. 161, No. 6, 2010, p. 515-521.

Research output: Contribution to journalArticle

Zailan, N, Abd Rashid, AH, Das, S, Abdul Mokti, NA, Hassan Basri, J, Teoh, SL, Wan Ngah, WZ & Mohd Yusof, YA 2010, 'Comparison of Chlorella vulgaris dressing and sodium alginate dressing: An experimental study in rats', Clinica Terapeutica, vol. 161, no. 6, pp. 515-521.
Zailan, N. ; Abd Rashid, Abdul Halim ; Das, Srijit ; Abdul Mokti, N. A. ; Hassan Basri, J. ; Teoh, Seong Lin ; Wan Ngah, W. Z. ; Mohd Yusof, Yasmin Anum. / Comparison of Chlorella vulgaris dressing and sodium alginate dressing : An experimental study in rats. In: Clinica Terapeutica. 2010 ; Vol. 161, No. 6. pp. 515-521.
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