Comparison of abtectcell III and diamed red cell antibody screening kit for detection of clinically significant red cells alloantibody

Sharifah Mai Sarah Syed Azim, Nor Asiah Muhamad, Leong Chooi Fun, Noor Hamidah Hussin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Antibody screening is important for the antenatal screening and pre-transfusion tests. This study aimed to compare the MUT/Mur kodecytesAbtectcell III (CSL Abtectcell III) red cell antibody screening kit with DiaMed ID-Dia Cell I-II-III Asia that was then used in our laboratory. In this study, 125 samples were randomly chosen, with 67 samples of known antibody specificities and 58 samples identified as negative for antibody, as the negative control. Concordant negative results were obtained in 57 out of 58 antibody negative samples. Concordant antibody positive results with both reagents were seen in 49 out of 67 samples. There were 18 discrepant results of antibody screening with CSL Abtetcell III (16/18 for vMNS antibodies). The sensitivity and specificity for CSL Abtectcell III were 73.0% and 98.3% respectively. In conclusion, the CSL Abtectcell III reagent would be an acceptable alternative for screening of red cell alloantibodies. It was able to detect all the clinically significant alloantibodies.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalMalaysian Journal of Pathology
Volume37
Issue number2
Publication statusPublished - 1 Aug 2015

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Isoantibodies
Antibodies
Antibody Specificity
Prenatal Diagnosis
Sensitivity and Specificity

Keywords

  • Blood groups
  • RBC antigens and antibodies
  • VMNS

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Histology

Cite this

Comparison of abtectcell III and diamed red cell antibody screening kit for detection of clinically significant red cells alloantibody. / Syed Azim, Sharifah Mai Sarah; Muhamad, Nor Asiah; Chooi Fun, Leong; Hussin, Noor Hamidah.

In: Malaysian Journal of Pathology, Vol. 37, No. 2, 01.08.2015, p. 109-114.

Research output: Contribution to journalArticle

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