Comparison between tertalolol and atenolol on submaximal exercise in hypertensive patients

M. M N Nor Anita, M. Siti Mariah, A. R. Tariq

    Research output: Contribution to journalArticle

    Abstract

    The effects of beta-blockers on resting values do not provide an adequate measure of beta adrenergic antagonism. In assessing beta-blockade; exercise testing have been most widely used. However, in patients whose cardiovascular responses are compromised e.g. in hypertensives; simpler tests like submaximal dynamic and static exercises which mimic the real life situation, may yield sufficient information. The aim of this study is to assess the effects of tertatolol compared to atenolol on blood pressure and heart rate during dynamic and static exercises. Results showed that both types of beta-blockers reduced systolic and diastolic pressure, heart rate and myocardial oxygen consumption before and during submaximal exercise. After 3 months of treatment, tertatolol 10 mg. o.d. is therapeutically equivalent to 100 mg. o.d. atenolol, with atenolol showing greater reductions in diastolic pressure (by 20 mm Hg when compared to 12 mm Hg following tertatolol treatment) during sustained muscular contractions. In comparison with other studies, tertatolol may be more beneficial to older patients (> 40 years) who are faced with acute bouts of physical exertion; which in the sedentary, could be a significant form of stress.

    Original languageEnglish
    Pages (from-to)65-71
    Number of pages7
    JournalAsia Pacific Journal of Pharmacology
    Volume10
    Issue number2
    Publication statusPublished - 1995

    Fingerprint

    tertatolol
    Atenolol
    Exercise
    Blood Pressure
    Heart Rate
    Physical Exertion
    Muscle Contraction
    Oxygen Consumption
    Adrenergic Agents
    Therapeutics

    Keywords

    • atenolol
    • hypertension
    • submaximal exercise
    • tertatolol

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Comparison between tertalolol and atenolol on submaximal exercise in hypertensive patients. / Nor Anita, M. M N; Siti Mariah, M.; Tariq, A. R.

    In: Asia Pacific Journal of Pharmacology, Vol. 10, No. 2, 1995, p. 65-71.

    Research output: Contribution to journalArticle

    Nor Anita, M. M N ; Siti Mariah, M. ; Tariq, A. R. / Comparison between tertalolol and atenolol on submaximal exercise in hypertensive patients. In: Asia Pacific Journal of Pharmacology. 1995 ; Vol. 10, No. 2. pp. 65-71.
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