Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults

Goon Jo Aan, Nor Helwa Ezzah Nor Azman, Siti Madiani Abdul Ghani, Zalina Hamid, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Vitamin E is a fat-soluble compound and powerful antioxidant that have been shown to protect the cell membranes against damage caused by free radicals. Human vitamin E supplementation studies are usually limited to α-tocopherol but currently tocotrienols are also available. This study aims to compare the effects of tocotrienol rich fraction (TRF) with α-tocopherol (α-TF) supplementation on oxidative stress in healthy male and female older adults aged 50–55 years old. A total of 71 subjects both male and female aged between 50 and 55 years were divided into groups receiving placebo (n = 23), α-TF (n = 24) and TRF (n = 24) for six months. Blood was taken at baseline (month 0), 3 months and 6 months osf supplementation for determination of plasma malondialdehyde (MDA), protein carbonyl, total DNA damage, vitamin D concentration and vitamin E isomers. α-TF supplementation reduced plasma MDA and protein carbonyl in female subjects after 3 and 6 months. TRF supplementation reduced MDA levels in both males and females as early as 3 months while DNA damage was reduced in females only at 6 months. Supplementation with α-TF and TRF increased plasma vitamin D concentration in both males and females after 6 months, but vitamin D concentration in male subjects were significantly higher compared to female subjects in TRF group. Vitamin E isomer determination showed α-TF, α-tocotrienol and γ-tocotrienol were increased in both male and female subjects. In conclusion, TRF supplementation effects were different from α-TF in reducing oxidative stress markers and vitamin D levels with a more pronounced effect in female subjects.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalClinical Nutrition ESPEN
Volume21
DOIs
Publication statusPublished - 1 Oct 2017

Fingerprint

Tocotrienols
Tocopherols
Oxidative Stress
Vitamin E
Vitamin D
Malondialdehyde
DNA Damage
Blood Proteins
palm oil
Free Radicals
Antioxidants
Fats
Placebos
Cell Membrane

Keywords

  • Aging
  • Antioxidant
  • Oxidative stress
  • Tocopherol
  • Tocotrienol

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults. / Jo Aan, Goon; Nor Azman, Nor Helwa Ezzah; Abdul Ghani, Siti Madiani; Hamid, Zalina; Wan Ngah, Wan Zurinah.

In: Clinical Nutrition ESPEN, Vol. 21, 01.10.2017, p. 1-12.

Research output: Contribution to journalArticle

Jo Aan, Goon ; Nor Azman, Nor Helwa Ezzah ; Abdul Ghani, Siti Madiani ; Hamid, Zalina ; Wan Ngah, Wan Zurinah. / Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults. In: Clinical Nutrition ESPEN. 2017 ; Vol. 21. pp. 1-12.
@article{aa9bb15fd6d54e14a3ef07b05d5fd3ef,
title = "Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults",
abstract = "Vitamin E is a fat-soluble compound and powerful antioxidant that have been shown to protect the cell membranes against damage caused by free radicals. Human vitamin E supplementation studies are usually limited to α-tocopherol but currently tocotrienols are also available. This study aims to compare the effects of tocotrienol rich fraction (TRF) with α-tocopherol (α-TF) supplementation on oxidative stress in healthy male and female older adults aged 50–55 years old. A total of 71 subjects both male and female aged between 50 and 55 years were divided into groups receiving placebo (n = 23), α-TF (n = 24) and TRF (n = 24) for six months. Blood was taken at baseline (month 0), 3 months and 6 months osf supplementation for determination of plasma malondialdehyde (MDA), protein carbonyl, total DNA damage, vitamin D concentration and vitamin E isomers. α-TF supplementation reduced plasma MDA and protein carbonyl in female subjects after 3 and 6 months. TRF supplementation reduced MDA levels in both males and females as early as 3 months while DNA damage was reduced in females only at 6 months. Supplementation with α-TF and TRF increased plasma vitamin D concentration in both males and females after 6 months, but vitamin D concentration in male subjects were significantly higher compared to female subjects in TRF group. Vitamin E isomer determination showed α-TF, α-tocotrienol and γ-tocotrienol were increased in both male and female subjects. In conclusion, TRF supplementation effects were different from α-TF in reducing oxidative stress markers and vitamin D levels with a more pronounced effect in female subjects.",
keywords = "Aging, Antioxidant, Oxidative stress, Tocopherol, Tocotrienol",
author = "{Jo Aan}, Goon and {Nor Azman}, {Nor Helwa Ezzah} and {Abdul Ghani}, {Siti Madiani} and Zalina Hamid and {Wan Ngah}, {Wan Zurinah}",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.clnesp.2017.07.004",
language = "English",
volume = "21",
pages = "1--12",
journal = "Clinical Nutrition ESPEN",
issn = "2405-4577",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Comparing palm oil tocotrienol rich fraction with α-tocopherol supplementation on oxidative stress in healthy older adults

AU - Jo Aan, Goon

AU - Nor Azman, Nor Helwa Ezzah

AU - Abdul Ghani, Siti Madiani

AU - Hamid, Zalina

AU - Wan Ngah, Wan Zurinah

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Vitamin E is a fat-soluble compound and powerful antioxidant that have been shown to protect the cell membranes against damage caused by free radicals. Human vitamin E supplementation studies are usually limited to α-tocopherol but currently tocotrienols are also available. This study aims to compare the effects of tocotrienol rich fraction (TRF) with α-tocopherol (α-TF) supplementation on oxidative stress in healthy male and female older adults aged 50–55 years old. A total of 71 subjects both male and female aged between 50 and 55 years were divided into groups receiving placebo (n = 23), α-TF (n = 24) and TRF (n = 24) for six months. Blood was taken at baseline (month 0), 3 months and 6 months osf supplementation for determination of plasma malondialdehyde (MDA), protein carbonyl, total DNA damage, vitamin D concentration and vitamin E isomers. α-TF supplementation reduced plasma MDA and protein carbonyl in female subjects after 3 and 6 months. TRF supplementation reduced MDA levels in both males and females as early as 3 months while DNA damage was reduced in females only at 6 months. Supplementation with α-TF and TRF increased plasma vitamin D concentration in both males and females after 6 months, but vitamin D concentration in male subjects were significantly higher compared to female subjects in TRF group. Vitamin E isomer determination showed α-TF, α-tocotrienol and γ-tocotrienol were increased in both male and female subjects. In conclusion, TRF supplementation effects were different from α-TF in reducing oxidative stress markers and vitamin D levels with a more pronounced effect in female subjects.

AB - Vitamin E is a fat-soluble compound and powerful antioxidant that have been shown to protect the cell membranes against damage caused by free radicals. Human vitamin E supplementation studies are usually limited to α-tocopherol but currently tocotrienols are also available. This study aims to compare the effects of tocotrienol rich fraction (TRF) with α-tocopherol (α-TF) supplementation on oxidative stress in healthy male and female older adults aged 50–55 years old. A total of 71 subjects both male and female aged between 50 and 55 years were divided into groups receiving placebo (n = 23), α-TF (n = 24) and TRF (n = 24) for six months. Blood was taken at baseline (month 0), 3 months and 6 months osf supplementation for determination of plasma malondialdehyde (MDA), protein carbonyl, total DNA damage, vitamin D concentration and vitamin E isomers. α-TF supplementation reduced plasma MDA and protein carbonyl in female subjects after 3 and 6 months. TRF supplementation reduced MDA levels in both males and females as early as 3 months while DNA damage was reduced in females only at 6 months. Supplementation with α-TF and TRF increased plasma vitamin D concentration in both males and females after 6 months, but vitamin D concentration in male subjects were significantly higher compared to female subjects in TRF group. Vitamin E isomer determination showed α-TF, α-tocotrienol and γ-tocotrienol were increased in both male and female subjects. In conclusion, TRF supplementation effects were different from α-TF in reducing oxidative stress markers and vitamin D levels with a more pronounced effect in female subjects.

KW - Aging

KW - Antioxidant

KW - Oxidative stress

KW - Tocopherol

KW - Tocotrienol

UR - http://www.scopus.com/inward/record.url?scp=85026318062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026318062&partnerID=8YFLogxK

U2 - 10.1016/j.clnesp.2017.07.004

DO - 10.1016/j.clnesp.2017.07.004

M3 - Article

VL - 21

SP - 1

EP - 12

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

SN - 2405-4577

ER -