Comparing palm oil, tocotrienol-rich fraction and α-tocopherol supplementation on the antioxidant levels of older adults

Nor Helwa Ezzah Nor Azman, Goon Jo Aan, Siti Madiani Abdul Ghani, Zalina Hamid, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Tocotrienol and tocopherol are known to prevent numerous degenerative diseases. The aim of this study is to compare the effects of tocotrienol-rich fraction (TRF) with α-tocopherol (α-TF) on the antioxidant status of healthy individuals aged between 50 and 55 years. Methods: Volunteers were divided into groups receiving placebo (n = 23), α-TF (n = 24) and TRF (n = 24). Fasting venous blood samples were taken at baseline (0 month), 3 months and 6 months of supplementation for the determination of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities as well as for reduced glutathione (GSH) and oxidized glutathione (GSSG) concentrations. Results: CAT and GPx were unaffected by TRF and α-TF supplementations. SOD activity increased significantly after six months of TRF supplementation. Analysis by gender showed that only female subjects had significant increases in SOD and GPx activities after six months of TRF supplementation. GPx activity was also significantly higher in females compared to males after six months of TRF supplementation. The GSH/GSSG ratio increased significantly after six months of TRF and α-TF supplementation in only the female subjects. Conclusion: TRF and α-TF supplementation exhibited similar effects to the antioxidant levels of older adults with TRF having more significant effects in females.

Original languageEnglish
Article number74
JournalAntioxidants
Volume7
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

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Tocotrienols
Tocopherols
Antioxidants
Glutathione Peroxidase
Glutathione Disulfide
Superoxide Dismutase
Catalase
palm oil
Glutathione
Volunteers
Fasting
Blood
Placebos

Keywords

  • Aging
  • Enzyme
  • Oxidative status
  • Oxidative stress
  • Vitamin E

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Comparing palm oil, tocotrienol-rich fraction and α-tocopherol supplementation on the antioxidant levels of older adults. / Azman, Nor Helwa Ezzah Nor; Jo Aan, Goon; Ghani, Siti Madiani Abdul; Hamid, Zalina; Ngah, Wan Zurinah Wan.

In: Antioxidants, Vol. 7, No. 6, 74, 01.06.2018.

Research output: Contribution to journalArticle

Azman, Nor Helwa Ezzah Nor ; Jo Aan, Goon ; Ghani, Siti Madiani Abdul ; Hamid, Zalina ; Ngah, Wan Zurinah Wan. / Comparing palm oil, tocotrienol-rich fraction and α-tocopherol supplementation on the antioxidant levels of older adults. In: Antioxidants. 2018 ; Vol. 7, No. 6.
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