Comparing membrane computing with ordinary differential equation in modeling a biological process in liver cell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Most of the biological processes such as the processes in liver cell have been modeled by using the approach of ordinary differential equation. Such conventional model has demonstrated drawbacks and limitations primarily in preserving the stochastic and nondeterministic behaviors of biological processes by characterizing them as continuous and deterministic processes. Membrane computing has been considered as an alternative to address these limitations by providing modeling capabilities in representing the structure and processes of biological systems essential for biological applications. This study was carried out to investigate the modeling of hormone-induced calcium oscillations in liver cell with membrane computing. Simulation strategy of Gillespie algorithm and the method of model checking with Probabilistic Symbolic Model Checker were used to verify and validate the membrane computing model. The results produced by membrane computing model were compared with the results from ordinary differential equation model. The simulation and model checking of membrane computing model of the hormone-induced calcium oscillations showed that the fundamental properties of the biological process were preserved. Membrane computing model has provided a better approach in accommodating the structure and processes of hormone-induced calcium oscillations system by sustaining the basic properties of the system compared with ordinary differential equation model. However there were some other issues such as the selection of kinetic constants according to the behavior of biological processes has to be addressed to strengthen membrane computing capability in modeling biological processes.

Original languageEnglish
Title of host publicationProceedings - 2011 6th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2011
Pages278-283
Number of pages6
DOIs
Publication statusPublished - 2011
Event6th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2011 - Penang
Duration: 27 Sep 201129 Sep 2011

Other

Other6th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2011
CityPenang
Period27/9/1129/9/11

Fingerprint

Membrane Computing
Ordinary differential equations
Liver
Ordinary differential equation
Membranes
Cell
Modeling
Hormones
Calcium
Model checking
Oscillation
Model
Model Checking
Biological systems
Biological Systems
Simulation
Kinetics
Verify

Keywords

  • Calcium oscillation
  • Gillespie algorithm
  • Membrane computing
  • PRISM model checking

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Applied Mathematics

Cite this

Muniyandi, R. C., & Mohd. Zin, A. (2011). Comparing membrane computing with ordinary differential equation in modeling a biological process in liver cell. In Proceedings - 2011 6th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2011 (pp. 278-283). [6046913] https://doi.org/10.1109/BIC-TA.2011.68

Comparing membrane computing with ordinary differential equation in modeling a biological process in liver cell. / Muniyandi, Ravie Chandren; Mohd. Zin, Abdullah.

Proceedings - 2011 6th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2011. 2011. p. 278-283 6046913.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Muniyandi, RC & Mohd. Zin, A 2011, Comparing membrane computing with ordinary differential equation in modeling a biological process in liver cell. in Proceedings - 2011 6th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2011., 6046913, pp. 278-283, 6th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2011, Penang, 27/9/11. https://doi.org/10.1109/BIC-TA.2011.68
Muniyandi RC, Mohd. Zin A. Comparing membrane computing with ordinary differential equation in modeling a biological process in liver cell. In Proceedings - 2011 6th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2011. 2011. p. 278-283. 6046913 https://doi.org/10.1109/BIC-TA.2011.68
Muniyandi, Ravie Chandren ; Mohd. Zin, Abdullah. / Comparing membrane computing with ordinary differential equation in modeling a biological process in liver cell. Proceedings - 2011 6th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2011. 2011. pp. 278-283
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