Comparative evaluation of different commercial topical natural products base formulation on wound healing in normal and diabetic rats

Research output: Contribution to journalArticle

Abstract

Wound healing is impaired and delayed in diabetes state. The aim of the study was to compare the effects of different topical natural products; Olive Heal, olive oil and vitamin E on the wound healing process in normal and diabetic rats. The study was carried out using 56 male Sprague-Dawley rats which were assigned randomly into 7 groups: group I (normal wounded untreated), group II (normal wounded treated with Olive Heal), group III (diabetic wounded untreated), group IV (diabetic wounded treated with Jelonet®), group V (diabetic wounded treated with Olive Heal), group VI (diabetic wounded treated with olive oil), and group VII (diabetic wounded treated with palm vitamin E). Four full thickness excisions were made at the back of the rats. Wound healing was assessed by rate of wound closure and histological evaluation on the tenth day after wounding. All treatments were able to enhance the wound healing process by increasing rate of wound closure significantly (p < 0.05) compared to the group I and group III. For histological evaluation on re-epithelization, group VI showed high score compared to group I and group III (p < 0.05). There were no significant difference between groups (p > 0.05) on collagen deposition and neovascularization scores. However, all treatments showed high histological scores compared to group III. In conclusion, topical application of the natural products enhanced wound healing process in normal and diabetic rats. Industrial relevance. Wound healing impairment in diabetes mellitus patients is one of the complications which can debilitate patients. Natural products that can be used as topical dressing have been studied. This study was conducted to determine the ability of Olive Heal, olive oil and vitamin E in promoting wound healing. These treatments pose fewer side effects compared to the chemical drugs used commercially. In addition, antioxidant contents in these natural products may play a role to reduce radicals and act as scavengers against reactive species. It may protect the cells from oxidative damage thus expediting wound healing. This will explore the possibilities of commercializing these natural products as wound healing agents.

Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalInternational Journal of Applied Research in Natural Products
Volume9
Issue number4
Publication statusPublished - 2016

Fingerprint

Biological Products
Wound Healing
Olea
Vitamin E
Wounds and Injuries
Bandages
Sprague Dawley Rats
Diabetes Mellitus
Collagen
Therapeutics
Antioxidants
Pharmaceutical Preparations

Keywords

  • Diabetes
  • Olive Heal
  • Rats
  • Wound healing

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Complementary and alternative medicine

Cite this

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title = "Comparative evaluation of different commercial topical natural products base formulation on wound healing in normal and diabetic rats",
abstract = "Wound healing is impaired and delayed in diabetes state. The aim of the study was to compare the effects of different topical natural products; Olive Heal, olive oil and vitamin E on the wound healing process in normal and diabetic rats. The study was carried out using 56 male Sprague-Dawley rats which were assigned randomly into 7 groups: group I (normal wounded untreated), group II (normal wounded treated with Olive Heal), group III (diabetic wounded untreated), group IV (diabetic wounded treated with Jelonet{\circledR}), group V (diabetic wounded treated with Olive Heal), group VI (diabetic wounded treated with olive oil), and group VII (diabetic wounded treated with palm vitamin E). Four full thickness excisions were made at the back of the rats. Wound healing was assessed by rate of wound closure and histological evaluation on the tenth day after wounding. All treatments were able to enhance the wound healing process by increasing rate of wound closure significantly (p < 0.05) compared to the group I and group III. For histological evaluation on re-epithelization, group VI showed high score compared to group I and group III (p < 0.05). There were no significant difference between groups (p > 0.05) on collagen deposition and neovascularization scores. However, all treatments showed high histological scores compared to group III. In conclusion, topical application of the natural products enhanced wound healing process in normal and diabetic rats. Industrial relevance. Wound healing impairment in diabetes mellitus patients is one of the complications which can debilitate patients. Natural products that can be used as topical dressing have been studied. This study was conducted to determine the ability of Olive Heal, olive oil and vitamin E in promoting wound healing. These treatments pose fewer side effects compared to the chemical drugs used commercially. In addition, antioxidant contents in these natural products may play a role to reduce radicals and act as scavengers against reactive species. It may protect the cells from oxidative damage thus expediting wound healing. This will explore the possibilities of commercializing these natural products as wound healing agents.",
keywords = "Diabetes, Olive Heal, Rats, Wound healing",
author = "Surayya Razali and Norazlina Mohamed and {Mohd Ramli}, {Elvy Suhana} and Norliza Muhammad",
year = "2016",
language = "English",
volume = "9",
pages = "28--34",
journal = "International Journal of Applied Research in Natural Products",
issn = "1940-6223",
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T1 - Comparative evaluation of different commercial topical natural products base formulation on wound healing in normal and diabetic rats

AU - Razali, Surayya

AU - Mohamed, Norazlina

AU - Mohd Ramli, Elvy Suhana

AU - Muhammad, Norliza

PY - 2016

Y1 - 2016

N2 - Wound healing is impaired and delayed in diabetes state. The aim of the study was to compare the effects of different topical natural products; Olive Heal, olive oil and vitamin E on the wound healing process in normal and diabetic rats. The study was carried out using 56 male Sprague-Dawley rats which were assigned randomly into 7 groups: group I (normal wounded untreated), group II (normal wounded treated with Olive Heal), group III (diabetic wounded untreated), group IV (diabetic wounded treated with Jelonet®), group V (diabetic wounded treated with Olive Heal), group VI (diabetic wounded treated with olive oil), and group VII (diabetic wounded treated with palm vitamin E). Four full thickness excisions were made at the back of the rats. Wound healing was assessed by rate of wound closure and histological evaluation on the tenth day after wounding. All treatments were able to enhance the wound healing process by increasing rate of wound closure significantly (p < 0.05) compared to the group I and group III. For histological evaluation on re-epithelization, group VI showed high score compared to group I and group III (p < 0.05). There were no significant difference between groups (p > 0.05) on collagen deposition and neovascularization scores. However, all treatments showed high histological scores compared to group III. In conclusion, topical application of the natural products enhanced wound healing process in normal and diabetic rats. Industrial relevance. Wound healing impairment in diabetes mellitus patients is one of the complications which can debilitate patients. Natural products that can be used as topical dressing have been studied. This study was conducted to determine the ability of Olive Heal, olive oil and vitamin E in promoting wound healing. These treatments pose fewer side effects compared to the chemical drugs used commercially. In addition, antioxidant contents in these natural products may play a role to reduce radicals and act as scavengers against reactive species. It may protect the cells from oxidative damage thus expediting wound healing. This will explore the possibilities of commercializing these natural products as wound healing agents.

AB - Wound healing is impaired and delayed in diabetes state. The aim of the study was to compare the effects of different topical natural products; Olive Heal, olive oil and vitamin E on the wound healing process in normal and diabetic rats. The study was carried out using 56 male Sprague-Dawley rats which were assigned randomly into 7 groups: group I (normal wounded untreated), group II (normal wounded treated with Olive Heal), group III (diabetic wounded untreated), group IV (diabetic wounded treated with Jelonet®), group V (diabetic wounded treated with Olive Heal), group VI (diabetic wounded treated with olive oil), and group VII (diabetic wounded treated with palm vitamin E). Four full thickness excisions were made at the back of the rats. Wound healing was assessed by rate of wound closure and histological evaluation on the tenth day after wounding. All treatments were able to enhance the wound healing process by increasing rate of wound closure significantly (p < 0.05) compared to the group I and group III. For histological evaluation on re-epithelization, group VI showed high score compared to group I and group III (p < 0.05). There were no significant difference between groups (p > 0.05) on collagen deposition and neovascularization scores. However, all treatments showed high histological scores compared to group III. In conclusion, topical application of the natural products enhanced wound healing process in normal and diabetic rats. Industrial relevance. Wound healing impairment in diabetes mellitus patients is one of the complications which can debilitate patients. Natural products that can be used as topical dressing have been studied. This study was conducted to determine the ability of Olive Heal, olive oil and vitamin E in promoting wound healing. These treatments pose fewer side effects compared to the chemical drugs used commercially. In addition, antioxidant contents in these natural products may play a role to reduce radicals and act as scavengers against reactive species. It may protect the cells from oxidative damage thus expediting wound healing. This will explore the possibilities of commercializing these natural products as wound healing agents.

KW - Diabetes

KW - Olive Heal

KW - Rats

KW - Wound healing

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