Comparative efficacy of perindopril and enalapril once daily using 24-hour ambulatory blood pressure monitoring

Khalid Yusoff, T. A. Razak, N. Yusof, N. M. Rafee

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    ACE inhibitors are important therapeutic agents in controlling hypertension, correcting some of its pathophysiological derangement and improving its prognosis. While there are many such agents, there may be some important differences between them. This placebo run-in, double blind, crossover study, using 24-hour ambulatory blood pressure monitoring, compares the efficacy of perindopril 4-8 mg and enalapril 10-20 mg as once daily antihypertensive agents on 32 patients. For diastolic blood pressure (DBP), perindopril had a placebo-corrected peak (P) reduction of blood pressure (BP) of -6.4 ± 1.3 mmHg vs its placebo-corrected trough (T) of -5.2 ± 1.7 mmHg. Enalapril had a reduction in DBP of -8.5 ± 1.3 mmHg (P) and -5.7 ± 1.7 mmHg (T). For systolic blood pressure (SBP), perindopril had a reduction of -7.5 ± 1.6 mmHg (P) vs -7.3 ± 2.2 mmHg (T) compared to enalapril with -10.8 ± 1.6 mmHg (P) vs -8.3 ± 2.3 mmHg (T). Placebo-corrected trough-to-peak ratio (SBP/DBP) for perindopril was 0.97/0.81 vs 0.77/0.67 for enalapril. There was no difference noted in 24-hour mean BP, area under the curve or post-dose casual BP measurements. Both perindopril and enalapril were well tolerated and the two treatment groups had similar safety profiles. Perindopril thus had a predictable and sustained blood pressure effect giving a 24-hour cover for the patient without excessive peak effect or poor trough effect.

    Original languageEnglish
    Pages (from-to)277-280
    Number of pages4
    JournalInternational Journal of Clinical Practice
    Volume53
    Issue number4
    Publication statusPublished - 1999

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    Perindopril
    Ambulatory Blood Pressure Monitoring
    Enalapril
    Blood Pressure
    Placebos
    Double-Blind Method
    Angiotensin-Converting Enzyme Inhibitors

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Comparative efficacy of perindopril and enalapril once daily using 24-hour ambulatory blood pressure monitoring. / Yusoff, Khalid; Razak, T. A.; Yusof, N.; Rafee, N. M.

    In: International Journal of Clinical Practice, Vol. 53, No. 4, 1999, p. 277-280.

    Research output: Contribution to journalArticle

    Yusoff, Khalid ; Razak, T. A. ; Yusof, N. ; Rafee, N. M. / Comparative efficacy of perindopril and enalapril once daily using 24-hour ambulatory blood pressure monitoring. In: International Journal of Clinical Practice. 1999 ; Vol. 53, No. 4. pp. 277-280.
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