Comparative effects of palm vitamin E and α-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats

M. Musalmah, M. Y. Nizrana, A. H. Fairuz, A. H. NoorAini, A. L. Azian, M. T. Gapor, W. Z. Wan Ngah

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    The effect of supplementing 200 mg/kg body weight palm vitamin E (PVE) and 200 mg/kg body weight α-tocopherol (α-Toc) on the healing of wounds in streptozotocin-induced diabetic rats was evaluated. The antioxidant potencies of these two preparations of vitamin E were also evaluated by determining the antioxidant enzyme activities, namely, glutathione peroxidase (GPx) and superoxide dismutase (SOD), and malondialdehyde (MDA) levels in the healing of dermal wounds. Healing was evaluated by measuring wound contractions and protein contents in the healing wounds. Cellular redistribution and collagen deposition were assessed morphologically using cross-sections of paraffin-embedded day-10 wounds stained according to the Van Gieson method. CPx and SOD activities as well as MDA levels were determined in homogenates of day-10 dermal wounds. Results showed that PVE had a greater potency to enhance wound repair and induce the increase in free radical-scavenging enzyme activities than α-Toc. Both PVE and α-Toc, however, were potent antioxidants and significantly reduced the lipid peroxidation levels in the wounds as measured by the reduction in MDA levels.

    Original languageEnglish
    Pages (from-to)575-580
    Number of pages6
    JournalLipids
    Volume40
    Issue number6
    DOIs
    Publication statusPublished - Jun 2005

    Fingerprint

    Tocopherols
    Vitamin E
    tocopherols
    Wound Healing
    vitamin E
    Rats
    Antioxidants
    Malondialdehyde
    Tissue
    malondialdehyde
    antioxidants
    rats
    Wounds and Injuries
    Enzyme activity
    Enzymes
    enzymes
    tissue repair
    Superoxide Dismutase
    superoxide dismutase
    enzyme activity

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Food Science
    • Biochemistry

    Cite this

    Musalmah, M., Nizrana, M. Y., Fairuz, A. H., NoorAini, A. H., Azian, A. L., Gapor, M. T., & Wan Ngah, W. Z. (2005). Comparative effects of palm vitamin E and α-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats. Lipids, 40(6), 575-580. https://doi.org/10.1007/s11745-005-1418-9

    Comparative effects of palm vitamin E and α-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats. / Musalmah, M.; Nizrana, M. Y.; Fairuz, A. H.; NoorAini, A. H.; Azian, A. L.; Gapor, M. T.; Wan Ngah, W. Z.

    In: Lipids, Vol. 40, No. 6, 06.2005, p. 575-580.

    Research output: Contribution to journalArticle

    Musalmah, M, Nizrana, MY, Fairuz, AH, NoorAini, AH, Azian, AL, Gapor, MT & Wan Ngah, WZ 2005, 'Comparative effects of palm vitamin E and α-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats', Lipids, vol. 40, no. 6, pp. 575-580. https://doi.org/10.1007/s11745-005-1418-9
    Musalmah, M. ; Nizrana, M. Y. ; Fairuz, A. H. ; NoorAini, A. H. ; Azian, A. L. ; Gapor, M. T. ; Wan Ngah, W. Z. / Comparative effects of palm vitamin E and α-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats. In: Lipids. 2005 ; Vol. 40, No. 6. pp. 575-580.
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