Comparative effects of a tocotrienol-rich fraction and tocopherol in aspirin-induced gastric lesions in rats

Mohd Ismail Nafeeza, A. M. Fauzee, Kamsiah Jaarin, M. T. Gapor

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This study examined the effects of a tocotrienol-rich fraction (TRF) obtained from palm oil on the healing of aspirin-induced gastric mucosal lesions. Thirty-six male Sprague-Dawley rats (200-250 g) were randomly divided into three groups. Group I was fed a vitamin E-deficient diet (control), Group II was fed a vitamin E-deficient diet supplemented with tocopherol (300 mg/kg food) and Group III was fed a vitamin E-deficient diet supplemented with TRF (300 mg/kg food). After eight weeks, the control and treated groups received a single intragastric dose of 400 mg/kg body weight aspirin. The rats were killed 24 h after exposure to aspirin. Assessment of gastric lesions showed a lower gastric lesion index in the TRF (P = 0.0005) and tocopherol groups (P = 0.0008) compared to the control. The gastric malondialdehyde (MDA) content was also lower in the TRF (P = 0.025) and tocopherol groups (P = 0.025) compared to control. There were, however, no significant differences in the gastric lesion index and gastric MDA content between the TRF and tocopherol-fed groups. There were no significant differences in the adherent gastric mucous concentration and gastric acid concentration among all groups. We conclude that the TRF and tocopherol are equally effective in preventing aspirin-induced gastric lesions. The most probable mechanism is through their ability to limit lipid peroxidation, which is involved in aspirin-induced gastric lesions.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalAsia Pacific Journal of Clinical Nutrition
Volume11
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

Tocotrienols
Tocopherols
Aspirin
Stomach
Vitamin E
Gastrointestinal Contents
Diet
Malondialdehyde
Food
Control Groups
Gastric Acid
Lipid Peroxidation
Sprague Dawley Rats
Body Weight

Keywords

  • Aspirin
  • Gastric lesions
  • Tocopherol
  • Tocotrienol

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Comparative effects of a tocotrienol-rich fraction and tocopherol in aspirin-induced gastric lesions in rats. / Nafeeza, Mohd Ismail; Fauzee, A. M.; Jaarin, Kamsiah; Gapor, M. T.

In: Asia Pacific Journal of Clinical Nutrition, Vol. 11, No. 4, 2002, p. 309-313.

Research output: Contribution to journalArticle

Nafeeza, Mohd Ismail ; Fauzee, A. M. ; Jaarin, Kamsiah ; Gapor, M. T. / Comparative effects of a tocotrienol-rich fraction and tocopherol in aspirin-induced gastric lesions in rats. In: Asia Pacific Journal of Clinical Nutrition. 2002 ; Vol. 11, No. 4. pp. 309-313.
@article{281989119e574d5595cd7b1f6f156d35,
title = "Comparative effects of a tocotrienol-rich fraction and tocopherol in aspirin-induced gastric lesions in rats",
abstract = "This study examined the effects of a tocotrienol-rich fraction (TRF) obtained from palm oil on the healing of aspirin-induced gastric mucosal lesions. Thirty-six male Sprague-Dawley rats (200-250 g) were randomly divided into three groups. Group I was fed a vitamin E-deficient diet (control), Group II was fed a vitamin E-deficient diet supplemented with tocopherol (300 mg/kg food) and Group III was fed a vitamin E-deficient diet supplemented with TRF (300 mg/kg food). After eight weeks, the control and treated groups received a single intragastric dose of 400 mg/kg body weight aspirin. The rats were killed 24 h after exposure to aspirin. Assessment of gastric lesions showed a lower gastric lesion index in the TRF (P = 0.0005) and tocopherol groups (P = 0.0008) compared to the control. The gastric malondialdehyde (MDA) content was also lower in the TRF (P = 0.025) and tocopherol groups (P = 0.025) compared to control. There were, however, no significant differences in the gastric lesion index and gastric MDA content between the TRF and tocopherol-fed groups. There were no significant differences in the adherent gastric mucous concentration and gastric acid concentration among all groups. We conclude that the TRF and tocopherol are equally effective in preventing aspirin-induced gastric lesions. The most probable mechanism is through their ability to limit lipid peroxidation, which is involved in aspirin-induced gastric lesions.",
keywords = "Aspirin, Gastric lesions, Tocopherol, Tocotrienol",
author = "Nafeeza, {Mohd Ismail} and Fauzee, {A. M.} and Kamsiah Jaarin and Gapor, {M. T.}",
year = "2002",
doi = "10.1046/j.1440-6047.2002.00298.x",
language = "English",
volume = "11",
pages = "309--313",
journal = "Asia Pacific Journal of Clinical Nutrition",
issn = "0964-7058",
publisher = "HEC Press",
number = "4",

}

TY - JOUR

T1 - Comparative effects of a tocotrienol-rich fraction and tocopherol in aspirin-induced gastric lesions in rats

AU - Nafeeza, Mohd Ismail

AU - Fauzee, A. M.

AU - Jaarin, Kamsiah

AU - Gapor, M. T.

PY - 2002

Y1 - 2002

N2 - This study examined the effects of a tocotrienol-rich fraction (TRF) obtained from palm oil on the healing of aspirin-induced gastric mucosal lesions. Thirty-six male Sprague-Dawley rats (200-250 g) were randomly divided into three groups. Group I was fed a vitamin E-deficient diet (control), Group II was fed a vitamin E-deficient diet supplemented with tocopherol (300 mg/kg food) and Group III was fed a vitamin E-deficient diet supplemented with TRF (300 mg/kg food). After eight weeks, the control and treated groups received a single intragastric dose of 400 mg/kg body weight aspirin. The rats were killed 24 h after exposure to aspirin. Assessment of gastric lesions showed a lower gastric lesion index in the TRF (P = 0.0005) and tocopherol groups (P = 0.0008) compared to the control. The gastric malondialdehyde (MDA) content was also lower in the TRF (P = 0.025) and tocopherol groups (P = 0.025) compared to control. There were, however, no significant differences in the gastric lesion index and gastric MDA content between the TRF and tocopherol-fed groups. There were no significant differences in the adherent gastric mucous concentration and gastric acid concentration among all groups. We conclude that the TRF and tocopherol are equally effective in preventing aspirin-induced gastric lesions. The most probable mechanism is through their ability to limit lipid peroxidation, which is involved in aspirin-induced gastric lesions.

AB - This study examined the effects of a tocotrienol-rich fraction (TRF) obtained from palm oil on the healing of aspirin-induced gastric mucosal lesions. Thirty-six male Sprague-Dawley rats (200-250 g) were randomly divided into three groups. Group I was fed a vitamin E-deficient diet (control), Group II was fed a vitamin E-deficient diet supplemented with tocopherol (300 mg/kg food) and Group III was fed a vitamin E-deficient diet supplemented with TRF (300 mg/kg food). After eight weeks, the control and treated groups received a single intragastric dose of 400 mg/kg body weight aspirin. The rats were killed 24 h after exposure to aspirin. Assessment of gastric lesions showed a lower gastric lesion index in the TRF (P = 0.0005) and tocopherol groups (P = 0.0008) compared to the control. The gastric malondialdehyde (MDA) content was also lower in the TRF (P = 0.025) and tocopherol groups (P = 0.025) compared to control. There were, however, no significant differences in the gastric lesion index and gastric MDA content between the TRF and tocopherol-fed groups. There were no significant differences in the adherent gastric mucous concentration and gastric acid concentration among all groups. We conclude that the TRF and tocopherol are equally effective in preventing aspirin-induced gastric lesions. The most probable mechanism is through their ability to limit lipid peroxidation, which is involved in aspirin-induced gastric lesions.

KW - Aspirin

KW - Gastric lesions

KW - Tocopherol

KW - Tocotrienol

UR - http://www.scopus.com/inward/record.url?scp=0036456886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036456886&partnerID=8YFLogxK

U2 - 10.1046/j.1440-6047.2002.00298.x

DO - 10.1046/j.1440-6047.2002.00298.x

M3 - Article

C2 - 12495264

AN - SCOPUS:0036456886

VL - 11

SP - 309

EP - 313

JO - Asia Pacific Journal of Clinical Nutrition

JF - Asia Pacific Journal of Clinical Nutrition

SN - 0964-7058

IS - 4

ER -