Comparative distribution of tocotrienols in livers of suckling and adult rats

Kamisah Yusof, M. Y. Norhayati, B. Zakri, M. Mazliadiyana, Faizah Othman, M. T. Gapor, A. Y. Asmadi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study was carried out to compare the patterns of hepatic distribution of palm vitamin E (palmvitee in suckling and adult rats. Suckling and male adult Wistar rats were given palmvitee in a dose of 0, 30 or 60 mg/kg body weight intra peritoneally for 14 days. The palmvitee was administered in the neonates from day 1 of life. It contained -tocopherol (TP, 21%), -tocotrienol (T3, 17%), -tocopherol (TP, 4%), -tocotrienol (T3, 33%) and -tocotrienol (T3, 24%). Twenty-four hours after the last injection of palmvitee, the rats were sacrificed and vitamin E concentrations in the liver of each rat were determined. All isomers of vitamin E were detected in groups given palmvitee. Administration of palmvitee increased total vitamin E and its isomers in suckling rats, and in adult rats that received 60 mg/kg palmvitee compared to the respective control groups. In adult rats given 30 mg/kg palmvitee, all tocotrienol isomers and total vitamin E but not TP and TP were raised. The patterns of hepatic vitamin E distribution in both groups of palmvitee-treated neonates and adult rats treated with 60 mg/ kg palmvitee corresponded well with the composition of palmvitee used, dissimilar to the adult rats given with 30 mg/kg palmvitee which had the highest proportion in TP concentration (64%). This preliminary study showed that tocotrienols were distributed differently in liver when given at 30 and 60 mg/kg body weight, postnatally or during adulthood.

Original languageEnglish
Pages (from-to)539-543
Number of pages5
JournalPakistan Journal of Nutrition
Volume5
Issue number6
DOIs
Publication statusPublished - 2006

Fingerprint

Tocotrienols
tocotrienols
suckling
Vitamin E
liver
vitamin E
Liver
rats
isomers
Tocopherols
tocopherols
Body Weight
neonates
body weight
adulthood
Wistar Rats
Control Groups
Injections
injection

Keywords

  • Adult rats
  • Liver
  • Neonates
  • Suckling rats
  • Tocotrienol

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Yusof, K., Norhayati, M. Y., Zakri, B., Mazliadiyana, M., Othman, F., Gapor, M. T., & Asmadi, A. Y. (2006). Comparative distribution of tocotrienols in livers of suckling and adult rats. Pakistan Journal of Nutrition, 5(6), 539-543. https://doi.org/10.3923/pjn.2006.539.543

Comparative distribution of tocotrienols in livers of suckling and adult rats. / Yusof, Kamisah; Norhayati, M. Y.; Zakri, B.; Mazliadiyana, M.; Othman, Faizah; Gapor, M. T.; Asmadi, A. Y.

In: Pakistan Journal of Nutrition, Vol. 5, No. 6, 2006, p. 539-543.

Research output: Contribution to journalArticle

Yusof, K, Norhayati, MY, Zakri, B, Mazliadiyana, M, Othman, F, Gapor, MT & Asmadi, AY 2006, 'Comparative distribution of tocotrienols in livers of suckling and adult rats', Pakistan Journal of Nutrition, vol. 5, no. 6, pp. 539-543. https://doi.org/10.3923/pjn.2006.539.543
Yusof, Kamisah ; Norhayati, M. Y. ; Zakri, B. ; Mazliadiyana, M. ; Othman, Faizah ; Gapor, M. T. ; Asmadi, A. Y. / Comparative distribution of tocotrienols in livers of suckling and adult rats. In: Pakistan Journal of Nutrition. 2006 ; Vol. 5, No. 6. pp. 539-543.
@article{7341dca43c394155819343e9a4e1a204,
title = "Comparative distribution of tocotrienols in livers of suckling and adult rats",
abstract = "This study was carried out to compare the patterns of hepatic distribution of palm vitamin E (palmvitee in suckling and adult rats. Suckling and male adult Wistar rats were given palmvitee in a dose of 0, 30 or 60 mg/kg body weight intra peritoneally for 14 days. The palmvitee was administered in the neonates from day 1 of life. It contained -tocopherol (TP, 21{\%}), -tocotrienol (T3, 17{\%}), -tocopherol (TP, 4{\%}), -tocotrienol (T3, 33{\%}) and -tocotrienol (T3, 24{\%}). Twenty-four hours after the last injection of palmvitee, the rats were sacrificed and vitamin E concentrations in the liver of each rat were determined. All isomers of vitamin E were detected in groups given palmvitee. Administration of palmvitee increased total vitamin E and its isomers in suckling rats, and in adult rats that received 60 mg/kg palmvitee compared to the respective control groups. In adult rats given 30 mg/kg palmvitee, all tocotrienol isomers and total vitamin E but not TP and TP were raised. The patterns of hepatic vitamin E distribution in both groups of palmvitee-treated neonates and adult rats treated with 60 mg/ kg palmvitee corresponded well with the composition of palmvitee used, dissimilar to the adult rats given with 30 mg/kg palmvitee which had the highest proportion in TP concentration (64{\%}). This preliminary study showed that tocotrienols were distributed differently in liver when given at 30 and 60 mg/kg body weight, postnatally or during adulthood.",
keywords = "Adult rats, Liver, Neonates, Suckling rats, Tocotrienol",
author = "Kamisah Yusof and Norhayati, {M. Y.} and B. Zakri and M. Mazliadiyana and Faizah Othman and Gapor, {M. T.} and Asmadi, {A. Y.}",
year = "2006",
doi = "10.3923/pjn.2006.539.543",
language = "English",
volume = "5",
pages = "539--543",
journal = "Pakistan Journal of Nutrition",
issn = "1680-5194",
publisher = "Asian Network for Scientific Information",
number = "6",

}

TY - JOUR

T1 - Comparative distribution of tocotrienols in livers of suckling and adult rats

AU - Yusof, Kamisah

AU - Norhayati, M. Y.

AU - Zakri, B.

AU - Mazliadiyana, M.

AU - Othman, Faizah

AU - Gapor, M. T.

AU - Asmadi, A. Y.

PY - 2006

Y1 - 2006

N2 - This study was carried out to compare the patterns of hepatic distribution of palm vitamin E (palmvitee in suckling and adult rats. Suckling and male adult Wistar rats were given palmvitee in a dose of 0, 30 or 60 mg/kg body weight intra peritoneally for 14 days. The palmvitee was administered in the neonates from day 1 of life. It contained -tocopherol (TP, 21%), -tocotrienol (T3, 17%), -tocopherol (TP, 4%), -tocotrienol (T3, 33%) and -tocotrienol (T3, 24%). Twenty-four hours after the last injection of palmvitee, the rats were sacrificed and vitamin E concentrations in the liver of each rat were determined. All isomers of vitamin E were detected in groups given palmvitee. Administration of palmvitee increased total vitamin E and its isomers in suckling rats, and in adult rats that received 60 mg/kg palmvitee compared to the respective control groups. In adult rats given 30 mg/kg palmvitee, all tocotrienol isomers and total vitamin E but not TP and TP were raised. The patterns of hepatic vitamin E distribution in both groups of palmvitee-treated neonates and adult rats treated with 60 mg/ kg palmvitee corresponded well with the composition of palmvitee used, dissimilar to the adult rats given with 30 mg/kg palmvitee which had the highest proportion in TP concentration (64%). This preliminary study showed that tocotrienols were distributed differently in liver when given at 30 and 60 mg/kg body weight, postnatally or during adulthood.

AB - This study was carried out to compare the patterns of hepatic distribution of palm vitamin E (palmvitee in suckling and adult rats. Suckling and male adult Wistar rats were given palmvitee in a dose of 0, 30 or 60 mg/kg body weight intra peritoneally for 14 days. The palmvitee was administered in the neonates from day 1 of life. It contained -tocopherol (TP, 21%), -tocotrienol (T3, 17%), -tocopherol (TP, 4%), -tocotrienol (T3, 33%) and -tocotrienol (T3, 24%). Twenty-four hours after the last injection of palmvitee, the rats were sacrificed and vitamin E concentrations in the liver of each rat were determined. All isomers of vitamin E were detected in groups given palmvitee. Administration of palmvitee increased total vitamin E and its isomers in suckling rats, and in adult rats that received 60 mg/kg palmvitee compared to the respective control groups. In adult rats given 30 mg/kg palmvitee, all tocotrienol isomers and total vitamin E but not TP and TP were raised. The patterns of hepatic vitamin E distribution in both groups of palmvitee-treated neonates and adult rats treated with 60 mg/ kg palmvitee corresponded well with the composition of palmvitee used, dissimilar to the adult rats given with 30 mg/kg palmvitee which had the highest proportion in TP concentration (64%). This preliminary study showed that tocotrienols were distributed differently in liver when given at 30 and 60 mg/kg body weight, postnatally or during adulthood.

KW - Adult rats

KW - Liver

KW - Neonates

KW - Suckling rats

KW - Tocotrienol

UR - http://www.scopus.com/inward/record.url?scp=33845607726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845607726&partnerID=8YFLogxK

U2 - 10.3923/pjn.2006.539.543

DO - 10.3923/pjn.2006.539.543

M3 - Article

AN - SCOPUS:33845607726

VL - 5

SP - 539

EP - 543

JO - Pakistan Journal of Nutrition

JF - Pakistan Journal of Nutrition

SN - 1680-5194

IS - 6

ER -