Comparative aspects of microRNA expression in canine and human cancers

Kabiru Sahabi, Gayathri T. Selvarajah, Rasedee Abdullah, Yoke Kqueen Cheah, Geok Chin Tan

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode of post-transcriptional gene regulation. The miRNAs that are involved in the initiation and progression of cancers are termed oncomiRs and several of them have been identified in canine and human cancers. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species. In this review, current information on the expression and roles of miRNAs in oncogenesis and progression of human and canine cancers, as well the roles miRNAs have in cancer stem cell biology, are highlighted. The potential for the use of miRNAs as therapeutic targets in personalized cancer therapy in domestic dogs and their possible application in human cancer counterparts are also discussed.

Original languageEnglish
Pages (from-to)162-171
Number of pages10
JournalJournal of Veterinary Science
Volume19
Issue number2
DOIs
Publication statusPublished - 1 Mar 2018

Fingerprint

MicroRNAs
microRNA
Canidae
neoplasms
dogs
Neoplasms
Neoplastic Stem Cells
therapeutics
Invertebrates
Cell Biology
Vertebrates
cell biology
Carcinogenesis
carcinogenesis
stem cells
Dogs
invertebrates
vertebrates
Therapeutics
organisms

Keywords

  • Dogs
  • Gene expression
  • MicroRNAs
  • Neoplasms
  • Stem cells

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparative aspects of microRNA expression in canine and human cancers. / Sahabi, Kabiru; Selvarajah, Gayathri T.; Abdullah, Rasedee; Cheah, Yoke Kqueen; Tan, Geok Chin.

In: Journal of Veterinary Science, Vol. 19, No. 2, 01.03.2018, p. 162-171.

Research output: Contribution to journalReview article

Sahabi, Kabiru ; Selvarajah, Gayathri T. ; Abdullah, Rasedee ; Cheah, Yoke Kqueen ; Tan, Geok Chin. / Comparative aspects of microRNA expression in canine and human cancers. In: Journal of Veterinary Science. 2018 ; Vol. 19, No. 2. pp. 162-171.
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