Community-acquired methicillin-resistant Staphylococcus aureus in a Malaysian tertiary centre

Noor Zetti Zainol Rashid, Norazlah Bahari, Amizah Othman, Roslinda Jaafar, Nurul Azmawati Mohamed, Idimaz Jabbari, Anita Sulong, Rohaidah Hashim, Norazah Ahmad

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a pathogen recognized to be distinct in both phenotype and genotype from hospital-acquired MRSA. We have identified CA-MRSA cases in Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia, including their antibiotic susceptibility patterns and genotypic characteristics. Cases were identified during January to December 2009 from routine clinical specimens, where culture and antibiotic susceptibility results yielded pauci-resistant MRSA isolates suspected as being CA-MRSA. The patients' clinical data were collected and their specimens were sent for molecular confirmation and analysis. Five cases of CA-MRSA were identified, which had a multi-sensitive pattern on antibiotic susceptibility tests and were resistant to only penicillin and oxacillin. All cases were skin and soft-tissue infections, including diabetic foot with gangrene, infected scalp hematoma, philtrum abscess in a healthcare worker, thrombophlebitis complicated with abscess and infected bedsore. All five cases were confirmed MRSA by detection of mecA. SCCmec typing (ccr and mec complex) revealed SCCmec type IV for all cases except the infected bedsore case. Panton-Valentine leukocidin gene was positive in all isolates. As clinical features among methicillin-sensitive Staphylococcus aureus, CA-MRSA and "nosocomial CA-MRSA" are indistinct, early recognition is necessary in order to initiate appropriate antibiotics and infection control measures. Continual surveillance of pauci-resistant MRSA and molecular analysis are necessary in order to identify emerging strains as well as their epidemiology and transmission, both in the community and in healthcare setting.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Volume44
Issue number1
Publication statusPublished - 2013

Fingerprint

Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Pressure Ulcer
Malaysia
Abscess
Oxacillin
Community Health Services
Thrombophlebitis
Soft Tissue Infections
Diabetic Foot
Methicillin
Gangrene
Infection Control
Lip
Scalp
Penicillins
Hematoma
Staphylococcus aureus
Epidemiology
Genotype

Keywords

  • Community-acquired methicillin-resistance
  • Malaysia
  • Skin and soft tissue infections
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health

Cite this

Community-acquired methicillin-resistant Staphylococcus aureus in a Malaysian tertiary centre. / Zainol Rashid, Noor Zetti; Bahari, Norazlah; Othman, Amizah; Jaafar, Roslinda; Mohamed, Nurul Azmawati; Jabbari, Idimaz; Sulong, Anita; Hashim, Rohaidah; Ahmad, Norazah.

In: Southeast Asian Journal of Tropical Medicine and Public Health, Vol. 44, No. 1, 2013, p. 104-108.

Research output: Contribution to journalArticle

Zainol Rashid, Noor Zetti ; Bahari, Norazlah ; Othman, Amizah ; Jaafar, Roslinda ; Mohamed, Nurul Azmawati ; Jabbari, Idimaz ; Sulong, Anita ; Hashim, Rohaidah ; Ahmad, Norazah. / Community-acquired methicillin-resistant Staphylococcus aureus in a Malaysian tertiary centre. In: Southeast Asian Journal of Tropical Medicine and Public Health. 2013 ; Vol. 44, No. 1. pp. 104-108.
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