Colostrum supplementation protects against exercise - Induced oxidative stress in skeletal muscle in mice

Mahenderan Appukutty, Ammu Kutty Radhakrishnan, Kalavathy Ramasamy, Rajesh Ramasamy, Abu Bakar Abdul Majeed, Mohd Ismail Noor, Nik Shanita Safii, Bee Koon Poh, Karuthan Chinna, Nagaraja Haleagrahara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: This study examined the effects of bovine colostrum on exercise -induced modulation of antioxidant parameters in skeletal muscle in mice. Adult male BALB/c mice were randomly divided into four groups (control, colostrum alone, exercise and exercise with colostrum) and each group had three subgroups (day 0, 21 and 42). Colostrum groups of mice were given a daily oral supplement of 50 mg/kg body weight of bovine colostrum and the exercise group of mice were made to exercise on the treadmill for 30 minutes per day. Total antioxidants, lipid hydroperoxides, xanthine oxidase and super oxide dismutase level was assayed from the homogenate of hind limb skeletal muscle. Results: Exercise - induced a significant oxidative stress in skeletal muscles as evidenced by the elevated lipid hydroperoxides and xanthine oxidase levels. There was a significant decrease in skeletal muscle total antioxidants and superoxide dismutase levels. Daily colostrum supplement significantly reduced the lipid hydroperoxides and xanthine oxidase enzyme level and increased the total antioxidant levels in the leg muscle. Conclusion: Thus, the findings of this study showed that daily bovine colostrum supplementation was beneficial to skeletal muscle to reduce the oxidant-induced damage during muscular exercise.

Original languageEnglish
Article number649
JournalBMC Research Notes
Volume5
DOIs
Publication statusPublished - 2012

Fingerprint

Colostrum
Oxidative stress
Muscle
Skeletal Muscle
Oxidative Stress
Xanthine Oxidase
Lipid Peroxides
Antioxidants
Exercise equipment
Oxidants
Superoxide Dismutase
Oxides
Modulation
Leg
Extremities
Body Weight
Muscles
Control Groups
Enzymes

Keywords

  • Antioxidants
  • Bovine colostrum
  • Exercise
  • Lipid hydroperoxides
  • Skeletal muscle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Appukutty, M., Radhakrishnan, A. K., Ramasamy, K., Ramasamy, R., Abdul Majeed, A. B., Noor, M. I., ... Haleagrahara, N. (2012). Colostrum supplementation protects against exercise - Induced oxidative stress in skeletal muscle in mice. BMC Research Notes, 5, [649]. https://doi.org/10.1186/1756-0500-5-649

Colostrum supplementation protects against exercise - Induced oxidative stress in skeletal muscle in mice. / Appukutty, Mahenderan; Radhakrishnan, Ammu Kutty; Ramasamy, Kalavathy; Ramasamy, Rajesh; Abdul Majeed, Abu Bakar; Noor, Mohd Ismail; Safii, Nik Shanita; Poh, Bee Koon; Chinna, Karuthan; Haleagrahara, Nagaraja.

In: BMC Research Notes, Vol. 5, 649, 2012.

Research output: Contribution to journalArticle

Appukutty, M, Radhakrishnan, AK, Ramasamy, K, Ramasamy, R, Abdul Majeed, AB, Noor, MI, Safii, NS, Poh, BK, Chinna, K & Haleagrahara, N 2012, 'Colostrum supplementation protects against exercise - Induced oxidative stress in skeletal muscle in mice', BMC Research Notes, vol. 5, 649. https://doi.org/10.1186/1756-0500-5-649
Appukutty, Mahenderan ; Radhakrishnan, Ammu Kutty ; Ramasamy, Kalavathy ; Ramasamy, Rajesh ; Abdul Majeed, Abu Bakar ; Noor, Mohd Ismail ; Safii, Nik Shanita ; Poh, Bee Koon ; Chinna, Karuthan ; Haleagrahara, Nagaraja. / Colostrum supplementation protects against exercise - Induced oxidative stress in skeletal muscle in mice. In: BMC Research Notes. 2012 ; Vol. 5.
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