Colorectal screening using the immunochemical faecal occult blood test kit among the Malaysian cohort participants

Noraidatulakma Abdullah, Nazihah Abd Jalal, Norliza Ismail, Mohd Arman Kamaruddin, Nurul Syakima Abd Mutalib, Mohd Raziff Alias, Luqman Mazlan, Ismail Sagap, Rahman Jamal

Research output: Contribution to journalArticle

Abstract

Background: There has been a rapid increase in colorectal cancer (CRC) cases in Asian countries, including Malaysia. CRC is usually diagnosed at a late stage, and early detection of CRC is vital in improving survival. This study was conducted to determine the uptake rate of the immunochemical faecal occult blood test (iFOBT), the response rate to colonoscopy, and the CRC detection rate. We also wanted to identify the association between colorectal neoplasia and the Asia Pacific Colorectal Cancer Screening (APCS) scoring system. Methods: We recruited 2264 individuals from The Malaysian Cohort participants aged 35–65 years who consented to colorectal screening using the iFOBT kit from July 2017 until January 2019. Results: The response rate and positive iFOBT test rate of this study were 79.6% and 13.1% respectively. Among those with positive results, 125 individuals (52.7%) underwent colonoscopy; CRC was detected in six of them while 45 others (36.0%) had polyps. The overall CRC detection rate was 0.3% while the colorectal neoplasia detection rate (both colorectal cancer and colorectal polyps) was 2.3%. The APCS scoring indicated a significant association with colorectal neoplasia risk, with increasing trend by severity from moderate to high risk (3.46–11.14) compared to low risk. Most of the participants who were positive for iFOBT were those at high risk. Conclusions: The awareness of CRC risk and iFOBT screening are important strategies for early detection of CRC. We showed a CRC detection rate of 0.3 % among those who volunteered to have the iFOBT screening.

Original languageEnglish
Article number101656
JournalCancer Epidemiology
Volume65
DOIs
Publication statusPublished - Apr 2020

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Occult Blood
Hematologic Tests
Colorectal Neoplasms
Early Detection of Cancer
Colonoscopy
Polyps
Neoplasms
Malaysia

Keywords

  • Cancer
  • Colorectal
  • IFOBT
  • Screening
  • The Malaysian cohort

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

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Colorectal screening using the immunochemical faecal occult blood test kit among the Malaysian cohort participants. / Abdullah, Noraidatulakma; Abd Jalal, Nazihah; Ismail, Norliza; Kamaruddin, Mohd Arman; Abd Mutalib, Nurul Syakima; Alias, Mohd Raziff; Mazlan, Luqman; Sagap, Ismail; Jamal, Rahman.

In: Cancer Epidemiology, Vol. 65, 101656, 04.2020.

Research output: Contribution to journalArticle

Abdullah, Noraidatulakma ; Abd Jalal, Nazihah ; Ismail, Norliza ; Kamaruddin, Mohd Arman ; Abd Mutalib, Nurul Syakima ; Alias, Mohd Raziff ; Mazlan, Luqman ; Sagap, Ismail ; Jamal, Rahman. / Colorectal screening using the immunochemical faecal occult blood test kit among the Malaysian cohort participants. In: Cancer Epidemiology. 2020 ; Vol. 65.
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abstract = "Background: There has been a rapid increase in colorectal cancer (CRC) cases in Asian countries, including Malaysia. CRC is usually diagnosed at a late stage, and early detection of CRC is vital in improving survival. This study was conducted to determine the uptake rate of the immunochemical faecal occult blood test (iFOBT), the response rate to colonoscopy, and the CRC detection rate. We also wanted to identify the association between colorectal neoplasia and the Asia Pacific Colorectal Cancer Screening (APCS) scoring system. Methods: We recruited 2264 individuals from The Malaysian Cohort participants aged 35–65 years who consented to colorectal screening using the iFOBT kit from July 2017 until January 2019. Results: The response rate and positive iFOBT test rate of this study were 79.6{\%} and 13.1{\%} respectively. Among those with positive results, 125 individuals (52.7{\%}) underwent colonoscopy; CRC was detected in six of them while 45 others (36.0{\%}) had polyps. The overall CRC detection rate was 0.3{\%} while the colorectal neoplasia detection rate (both colorectal cancer and colorectal polyps) was 2.3{\%}. The APCS scoring indicated a significant association with colorectal neoplasia risk, with increasing trend by severity from moderate to high risk (3.46–11.14) compared to low risk. Most of the participants who were positive for iFOBT were those at high risk. Conclusions: The awareness of CRC risk and iFOBT screening are important strategies for early detection of CRC. We showed a CRC detection rate of 0.3 {\%} among those who volunteered to have the iFOBT screening.",
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AU - Abd Jalal, Nazihah

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AU - Kamaruddin, Mohd Arman

AU - Abd Mutalib, Nurul Syakima

AU - Alias, Mohd Raziff

AU - Mazlan, Luqman

AU - Sagap, Ismail

AU - Jamal, Rahman

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N2 - Background: There has been a rapid increase in colorectal cancer (CRC) cases in Asian countries, including Malaysia. CRC is usually diagnosed at a late stage, and early detection of CRC is vital in improving survival. This study was conducted to determine the uptake rate of the immunochemical faecal occult blood test (iFOBT), the response rate to colonoscopy, and the CRC detection rate. We also wanted to identify the association between colorectal neoplasia and the Asia Pacific Colorectal Cancer Screening (APCS) scoring system. Methods: We recruited 2264 individuals from The Malaysian Cohort participants aged 35–65 years who consented to colorectal screening using the iFOBT kit from July 2017 until January 2019. Results: The response rate and positive iFOBT test rate of this study were 79.6% and 13.1% respectively. Among those with positive results, 125 individuals (52.7%) underwent colonoscopy; CRC was detected in six of them while 45 others (36.0%) had polyps. The overall CRC detection rate was 0.3% while the colorectal neoplasia detection rate (both colorectal cancer and colorectal polyps) was 2.3%. The APCS scoring indicated a significant association with colorectal neoplasia risk, with increasing trend by severity from moderate to high risk (3.46–11.14) compared to low risk. Most of the participants who were positive for iFOBT were those at high risk. Conclusions: The awareness of CRC risk and iFOBT screening are important strategies for early detection of CRC. We showed a CRC detection rate of 0.3 % among those who volunteered to have the iFOBT screening.

AB - Background: There has been a rapid increase in colorectal cancer (CRC) cases in Asian countries, including Malaysia. CRC is usually diagnosed at a late stage, and early detection of CRC is vital in improving survival. This study was conducted to determine the uptake rate of the immunochemical faecal occult blood test (iFOBT), the response rate to colonoscopy, and the CRC detection rate. We also wanted to identify the association between colorectal neoplasia and the Asia Pacific Colorectal Cancer Screening (APCS) scoring system. Methods: We recruited 2264 individuals from The Malaysian Cohort participants aged 35–65 years who consented to colorectal screening using the iFOBT kit from July 2017 until January 2019. Results: The response rate and positive iFOBT test rate of this study were 79.6% and 13.1% respectively. Among those with positive results, 125 individuals (52.7%) underwent colonoscopy; CRC was detected in six of them while 45 others (36.0%) had polyps. The overall CRC detection rate was 0.3% while the colorectal neoplasia detection rate (both colorectal cancer and colorectal polyps) was 2.3%. The APCS scoring indicated a significant association with colorectal neoplasia risk, with increasing trend by severity from moderate to high risk (3.46–11.14) compared to low risk. Most of the participants who were positive for iFOBT were those at high risk. Conclusions: The awareness of CRC risk and iFOBT screening are important strategies for early detection of CRC. We showed a CRC detection rate of 0.3 % among those who volunteered to have the iFOBT screening.

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