Colorectal cancer patients in a tertiary referral centre in Malaysia

A five year follow-up review

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17 Citations (Scopus)

Abstract

Background: Colorectal cancer (CRC) is one of the major malignancies in the world. In Malaysia, CRC is fast becoming the commonest cause of cancer death. Its etiology is complex, involving both environmental and genetic factors. This study looked at the profile and outcome of five-year follow-up of patients with CRC. Materials and Methods: Retrospective case review study done on CRC patients at Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia. Patients' socio-demographic characteristics, modalities of treatment, cancer characteristics and outcome at 5-year follow up were extracted from the case records. Results: A total of 107 case records of patients were analyzed. Peak age of CRC presentation was 40-69 years (71.1%). Male to female ratio was 1.2:1 with Chinese predominance (52.3%). Anaemia and its related symptoms including per rectal bleeding was the commonest clinical presentation. The median duration of clinical presentation was 13 weeks (IQR 21.8). More than two-thirds presented as non-emergency cases (69.2%). Most patients presented with Dukes C stage(40.2%). The overall 5-year survival rate was 40% with local recurrence rate of 19.6%. Metastasis after curative-intend treatment (surgery with adjuvant therapy) developed in 26% of patients. Lower recurrence (p = 0.016, OR = 0.205) and metastatic disease (p = 0.02, OR = 0.24) found among the Chinese patients. Almost half of the patients defaulted follow up care (43%), most often within the first year of treatment (22.4%) and the Chinese were the least likely to default (p= 0.04, OR = 0.45). Conclusion: Socio-demographic profile of CRC patients in UKMMC is comparable to Asia pacific region. Apparent delay in seeking treatment gives rise to poor overall survival and local recurrence rates.

Original languageEnglish
Pages (from-to)1163-1166
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue number6
Publication statusPublished - 2009

Fingerprint

Malaysia
Tertiary Care Centers
Colorectal Neoplasms
Recurrence
Demography
Therapeutics
Neoplasms
Aftercare
Anemia
Cause of Death
Survival Rate
Hemorrhage
Neoplasm Metastasis
Survival

Keywords

  • Colorectal cancer
  • Delay in treatment
  • Rectal bleeding
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

@article{2b6dee969034406f8736f56f6f11942d,
title = "Colorectal cancer patients in a tertiary referral centre in Malaysia: A five year follow-up review",
abstract = "Background: Colorectal cancer (CRC) is one of the major malignancies in the world. In Malaysia, CRC is fast becoming the commonest cause of cancer death. Its etiology is complex, involving both environmental and genetic factors. This study looked at the profile and outcome of five-year follow-up of patients with CRC. Materials and Methods: Retrospective case review study done on CRC patients at Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia. Patients' socio-demographic characteristics, modalities of treatment, cancer characteristics and outcome at 5-year follow up were extracted from the case records. Results: A total of 107 case records of patients were analyzed. Peak age of CRC presentation was 40-69 years (71.1{\%}). Male to female ratio was 1.2:1 with Chinese predominance (52.3{\%}). Anaemia and its related symptoms including per rectal bleeding was the commonest clinical presentation. The median duration of clinical presentation was 13 weeks (IQR 21.8). More than two-thirds presented as non-emergency cases (69.2{\%}). Most patients presented with Dukes C stage(40.2{\%}). The overall 5-year survival rate was 40{\%} with local recurrence rate of 19.6{\%}. Metastasis after curative-intend treatment (surgery with adjuvant therapy) developed in 26{\%} of patients. Lower recurrence (p = 0.016, OR = 0.205) and metastatic disease (p = 0.02, OR = 0.24) found among the Chinese patients. Almost half of the patients defaulted follow up care (43{\%}), most often within the first year of treatment (22.4{\%}) and the Chinese were the least likely to default (p= 0.04, OR = 0.45). Conclusion: Socio-demographic profile of CRC patients in UKMMC is comparable to Asia pacific region. Apparent delay in seeking treatment gives rise to poor overall survival and local recurrence rates.",
keywords = "Colorectal cancer, Delay in treatment, Rectal bleeding, Survival",
author = "Rashid, {Mohd Radzniwan A} and {Abdul Aziz}, {Aznida Firzah} and Saharuddin Ahmad and Shah, {Shamsul Azhar} and Ismail Sagap",
year = "2009",
language = "English",
volume = "10",
pages = "1163--1166",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "6",

}

TY - JOUR

T1 - Colorectal cancer patients in a tertiary referral centre in Malaysia

T2 - A five year follow-up review

AU - Rashid, Mohd Radzniwan A

AU - Abdul Aziz, Aznida Firzah

AU - Ahmad, Saharuddin

AU - Shah, Shamsul Azhar

AU - Sagap, Ismail

PY - 2009

Y1 - 2009

N2 - Background: Colorectal cancer (CRC) is one of the major malignancies in the world. In Malaysia, CRC is fast becoming the commonest cause of cancer death. Its etiology is complex, involving both environmental and genetic factors. This study looked at the profile and outcome of five-year follow-up of patients with CRC. Materials and Methods: Retrospective case review study done on CRC patients at Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia. Patients' socio-demographic characteristics, modalities of treatment, cancer characteristics and outcome at 5-year follow up were extracted from the case records. Results: A total of 107 case records of patients were analyzed. Peak age of CRC presentation was 40-69 years (71.1%). Male to female ratio was 1.2:1 with Chinese predominance (52.3%). Anaemia and its related symptoms including per rectal bleeding was the commonest clinical presentation. The median duration of clinical presentation was 13 weeks (IQR 21.8). More than two-thirds presented as non-emergency cases (69.2%). Most patients presented with Dukes C stage(40.2%). The overall 5-year survival rate was 40% with local recurrence rate of 19.6%. Metastasis after curative-intend treatment (surgery with adjuvant therapy) developed in 26% of patients. Lower recurrence (p = 0.016, OR = 0.205) and metastatic disease (p = 0.02, OR = 0.24) found among the Chinese patients. Almost half of the patients defaulted follow up care (43%), most often within the first year of treatment (22.4%) and the Chinese were the least likely to default (p= 0.04, OR = 0.45). Conclusion: Socio-demographic profile of CRC patients in UKMMC is comparable to Asia pacific region. Apparent delay in seeking treatment gives rise to poor overall survival and local recurrence rates.

AB - Background: Colorectal cancer (CRC) is one of the major malignancies in the world. In Malaysia, CRC is fast becoming the commonest cause of cancer death. Its etiology is complex, involving both environmental and genetic factors. This study looked at the profile and outcome of five-year follow-up of patients with CRC. Materials and Methods: Retrospective case review study done on CRC patients at Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia. Patients' socio-demographic characteristics, modalities of treatment, cancer characteristics and outcome at 5-year follow up were extracted from the case records. Results: A total of 107 case records of patients were analyzed. Peak age of CRC presentation was 40-69 years (71.1%). Male to female ratio was 1.2:1 with Chinese predominance (52.3%). Anaemia and its related symptoms including per rectal bleeding was the commonest clinical presentation. The median duration of clinical presentation was 13 weeks (IQR 21.8). More than two-thirds presented as non-emergency cases (69.2%). Most patients presented with Dukes C stage(40.2%). The overall 5-year survival rate was 40% with local recurrence rate of 19.6%. Metastasis after curative-intend treatment (surgery with adjuvant therapy) developed in 26% of patients. Lower recurrence (p = 0.016, OR = 0.205) and metastatic disease (p = 0.02, OR = 0.24) found among the Chinese patients. Almost half of the patients defaulted follow up care (43%), most often within the first year of treatment (22.4%) and the Chinese were the least likely to default (p= 0.04, OR = 0.45). Conclusion: Socio-demographic profile of CRC patients in UKMMC is comparable to Asia pacific region. Apparent delay in seeking treatment gives rise to poor overall survival and local recurrence rates.

KW - Colorectal cancer

KW - Delay in treatment

KW - Rectal bleeding

KW - Survival

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M3 - Article

VL - 10

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JF - Asian Pacific Journal of Cancer Prevention

SN - 1513-7368

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