Colchicine prodrugs and codrugs: Chemistry and bioactivities

Abdullah A. Ghawanmeh, Kwok Feng Chong, Shaheen M. Sarkar, Muntaz Abu Bakar, Rizafizah Othaman, Rozida Mohd. Khalid

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nontoxic biofunctional compounds modified further affords a new entity in chemical structure with enhanced activity and selectivity. Moreover, nanocarrier formulation strategies have been used for colchicine delivery. This review paper focuses on colchicine nanoformulation, chemical synthesis of colchicine prodrugs and codrugs with different linkers, highlights linker chemical nature and biological activity of synthesized compounds. Additionally, classification of colchicine prodrugs based on type of conjugates is discussed, as biopolymers prodrugs, fluorescent prodrug, metal complexes prodrug, metal-labile prodrug and bioconjugate prodrug. Finally, we briefly summarized the biological importance of colchicine nanoformulation, colchicine prodrugs and codrugs.

Original languageEnglish
Pages (from-to)229-242
Number of pages14
JournalEuropean Journal of Medicinal Chemistry
Volume144
DOIs
Publication statusPublished - 20 Jan 2018

Fingerprint

Prodrugs
Colchicine
Bioactivity
Toxicity
Antimitotic Agents
Biopolymers
Coordination Complexes
Structure-Activity Relationship
Hybrid systems
Metals

Keywords

  • Biological activities
  • Codrugs
  • Colchicine
  • Prodrugs

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Colchicine prodrugs and codrugs : Chemistry and bioactivities. / Ghawanmeh, Abdullah A.; Chong, Kwok Feng; Sarkar, Shaheen M.; Abu Bakar, Muntaz; Othaman, Rizafizah; Mohd. Khalid, Rozida.

In: European Journal of Medicinal Chemistry, Vol. 144, 20.01.2018, p. 229-242.

Research output: Contribution to journalReview article

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