Cognitive profiles in parkinson’s disease and their correlation with dementia, anxiety and depression: A preliminary study

Wan Nor Azlen Wan Mohamad, Normah Che Din, Norlinah Mohamed Ibrahim

Research output: Contribution to journalArticle

Abstract

A cross-sectional study was carried out at a medical centre to determine the cognitive profiles of 30 Parkinson’s disease patients with age of 69.76 ± 7.39 years. Thirty-seven percent of the patients were found to be at risk for dementia. The scores on subscales of working memory and alternating verbal fluency were significantly lower in Parkinson’s disease patients who were older than 77 years old. The scores on a subtest of working memory on the Parkinson’s Disease Cognitive Rating Scale (PDCRS) were significantly lower in Parkinson’s disease patients with a duration of illness of more than 10 years. In cognitive measurement, the subtests of verbal memory, delayed free recall and verbal fluency on the PD¬CRS were significantly lower in patients with less than six years of education. The patients who had difficulty with sustained attention, working memory and movement had significant anxiety and depression symptoms. In conclusion, multiple patterns in cognitive profiles influence the quality of life of patients with Parkinson’s disease in multi-dimensional ways.

Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalMalaysian Journal of Medical Sciences
Volume22
Publication statusPublished - 1 Dec 2015

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Parkinson Disease
Dementia
Anxiety
Depression
Short-Term Memory
Repression (Psychology)
Cross-Sectional Studies
Quality of Life
Education

Keywords

  • Anxiety
  • Cognitive Parkinson’s disease
  • Dementia
  • Depression

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "A cross-sectional study was carried out at a medical centre to determine the cognitive profiles of 30 Parkinson’s disease patients with age of 69.76 ± 7.39 years. Thirty-seven percent of the patients were found to be at risk for dementia. The scores on subscales of working memory and alternating verbal fluency were significantly lower in Parkinson’s disease patients who were older than 77 years old. The scores on a subtest of working memory on the Parkinson’s Disease Cognitive Rating Scale (PDCRS) were significantly lower in Parkinson’s disease patients with a duration of illness of more than 10 years. In cognitive measurement, the subtests of verbal memory, delayed free recall and verbal fluency on the PD¬CRS were significantly lower in patients with less than six years of education. The patients who had difficulty with sustained attention, working memory and movement had significant anxiety and depression symptoms. In conclusion, multiple patterns in cognitive profiles influence the quality of life of patients with Parkinson’s disease in multi-dimensional ways.",
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