Clusterin as a potential marker in distinguishing cervical neoplasia

Ilambarthi Lokamani, Mee Lee Looi, Siti Aishah Md Ali, Ahmad Zailani Hatta Mohd Dali, A. Rahman A. Jamal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: To assess the immunoexpression of clusterin (CLU) in the progression of cervical neoplasia. STUDY DESIGN: A total of 127 paraffin sections of cervical tissue consisting of normal cervical tissue, cervical intraepithelial neoplasia (CIN) lesions, cervical squamous cell carcinomas (SCCs), and adenocarcinoma of the cervix were examined by immunohistochemistry. The findings were evaluated in relation to clinicopathologic factors including grade of differentiation and lymph node involvement. RESULTS: Immunopositivity of CLU was found in the cytoplasm of dysplastic cells, SCCs, and normal epithelium of the endocervical gland. There was negative expression in adenocarcinoma. High expression of CLU was found in CIN 3 compared to CIN 1 and CIN 2. The immunoreactivity of CLU was found in 95% of SCCs. The staining was positive in the upper 2/3 layers of the dysplastic epithelium for CIN 3 and showed a cluster pattern in cervical SCCs. There was no significant correlation between CLU immunoreactivity and lymph node involvement, as well as grade of differentiation. CONCLUSION: The overexpression of CLU in various stages of cervical lesions may serve as a potential marker to distinguish cervical neoplasia with borderline morphology features.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalAnalytical and Quantitative Cytology and Histology
Volume33
Issue number4
Publication statusPublished - 2011

Fingerprint

Clusterin
Cervical Intraepithelial Neoplasia
Squamous Cell Carcinoma
Neoplasms
Adenocarcinoma
Epithelium
Lymph Nodes
Cervix Uteri
Paraffin
Cytoplasm
Immunohistochemistry
Staining and Labeling

Keywords

  • Cervical cancer
  • Cervical dysplasia
  • Clusterin

ASJC Scopus subject areas

  • Anatomy
  • Histology

Cite this

Clusterin as a potential marker in distinguishing cervical neoplasia. / Lokamani, Ilambarthi; Looi, Mee Lee; Ali, Siti Aishah Md; Dali, Ahmad Zailani Hatta Mohd; A. Jamal, A. Rahman.

In: Analytical and Quantitative Cytology and Histology, Vol. 33, No. 4, 2011, p. 223-228.

Research output: Contribution to journalArticle

Lokamani, Ilambarthi ; Looi, Mee Lee ; Ali, Siti Aishah Md ; Dali, Ahmad Zailani Hatta Mohd ; A. Jamal, A. Rahman. / Clusterin as a potential marker in distinguishing cervical neoplasia. In: Analytical and Quantitative Cytology and Histology. 2011 ; Vol. 33, No. 4. pp. 223-228.
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