Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Acinetobacter spp. has emerged as an important opportunistic pathogen responsible for nosocomial infections in many health-care settings worldwide. The study describes the clinico-epidemiology and antimicrobial susceptibility of Acinetobacter spp. in a tertiary health-care institution. Methodology: Acinetobacter spp. were isolated from 141 specimens of the patients who reported to Universiti Kebangsaan Medical Centre (UKMMC). The sources of specimens were wound, skin and soft tissue, respiratory and urinary tract from patients in various wards. Clinio-epidemiological features of patients infected with Acinetobacter spp. were recorded. Standard bacteriological techniques with API 20NE kits and disk diffusion method were followed for identification and antibiotic sensitivity of the organisms. Results: One hundred and forty one patients with positive culture for Acinetobacter spp. were identified. Soft tissue/wound and respiratory tract were among the commonest sites of Acinetobacter spp. isolation. The isolates were most frequently obtained from ICU. All isolates were multi-drug resistant and had a resistance rate of more than 70% to most antibiotics, except polymyxin B. Conclusion: High prevalence of multi-drug resistance Acinetobacter spp. provides essential information on judicious antibiotic selection for empirical therapy in our health-care institution.

Original languageEnglish
JournalPakistan Journal of Medical Sciences
Volume29
Issue number2
Publication statusPublished - 2013

Fingerprint

Acinetobacter
Anti-Bacterial Agents
Delivery of Health Care
Respiratory System
Bacteriological Techniques
Polymyxin B
Wounds and Injuries
Multiple Drug Resistance
Tertiary Healthcare
Cross Infection
Urinary Tract
Epidemiology
Skin
Pharmaceutical Preparations

Keywords

  • Acinetobacter spp.
  • Antimicrobial susceptibility
  • Intensive care unit
  • Polymyxin B

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{e2e0073fb0774c6d92e9c4ad468b1945,
title = "Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species",
abstract = "Objectives: Acinetobacter spp. has emerged as an important opportunistic pathogen responsible for nosocomial infections in many health-care settings worldwide. The study describes the clinico-epidemiology and antimicrobial susceptibility of Acinetobacter spp. in a tertiary health-care institution. Methodology: Acinetobacter spp. were isolated from 141 specimens of the patients who reported to Universiti Kebangsaan Medical Centre (UKMMC). The sources of specimens were wound, skin and soft tissue, respiratory and urinary tract from patients in various wards. Clinio-epidemiological features of patients infected with Acinetobacter spp. were recorded. Standard bacteriological techniques with API 20NE kits and disk diffusion method were followed for identification and antibiotic sensitivity of the organisms. Results: One hundred and forty one patients with positive culture for Acinetobacter spp. were identified. Soft tissue/wound and respiratory tract were among the commonest sites of Acinetobacter spp. isolation. The isolates were most frequently obtained from ICU. All isolates were multi-drug resistant and had a resistance rate of more than 70{\%} to most antibiotics, except polymyxin B. Conclusion: High prevalence of multi-drug resistance Acinetobacter spp. provides essential information on judicious antibiotic selection for empirical therapy in our health-care institution.",
keywords = "Acinetobacter spp., Antimicrobial susceptibility, Intensive care unit, Polymyxin B",
author = "Shirin Biglari and Alfizah Hanafiah and Ramliza Ramli and Rahman, {Md. Mostafizur} and Khaithir, {Tzar Mohd Nizam}",
year = "2013",
language = "English",
volume = "29",
journal = "Pakistan Journal of Medical Sciences",
issn = "1682-024X",
publisher = "Professional Medical Publications",
number = "2",

}

TY - JOUR

T1 - Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species

AU - Biglari, Shirin

AU - Hanafiah, Alfizah

AU - Ramli, Ramliza

AU - Rahman, Md. Mostafizur

AU - Khaithir, Tzar Mohd Nizam

PY - 2013

Y1 - 2013

N2 - Objectives: Acinetobacter spp. has emerged as an important opportunistic pathogen responsible for nosocomial infections in many health-care settings worldwide. The study describes the clinico-epidemiology and antimicrobial susceptibility of Acinetobacter spp. in a tertiary health-care institution. Methodology: Acinetobacter spp. were isolated from 141 specimens of the patients who reported to Universiti Kebangsaan Medical Centre (UKMMC). The sources of specimens were wound, skin and soft tissue, respiratory and urinary tract from patients in various wards. Clinio-epidemiological features of patients infected with Acinetobacter spp. were recorded. Standard bacteriological techniques with API 20NE kits and disk diffusion method were followed for identification and antibiotic sensitivity of the organisms. Results: One hundred and forty one patients with positive culture for Acinetobacter spp. were identified. Soft tissue/wound and respiratory tract were among the commonest sites of Acinetobacter spp. isolation. The isolates were most frequently obtained from ICU. All isolates were multi-drug resistant and had a resistance rate of more than 70% to most antibiotics, except polymyxin B. Conclusion: High prevalence of multi-drug resistance Acinetobacter spp. provides essential information on judicious antibiotic selection for empirical therapy in our health-care institution.

AB - Objectives: Acinetobacter spp. has emerged as an important opportunistic pathogen responsible for nosocomial infections in many health-care settings worldwide. The study describes the clinico-epidemiology and antimicrobial susceptibility of Acinetobacter spp. in a tertiary health-care institution. Methodology: Acinetobacter spp. were isolated from 141 specimens of the patients who reported to Universiti Kebangsaan Medical Centre (UKMMC). The sources of specimens were wound, skin and soft tissue, respiratory and urinary tract from patients in various wards. Clinio-epidemiological features of patients infected with Acinetobacter spp. were recorded. Standard bacteriological techniques with API 20NE kits and disk diffusion method were followed for identification and antibiotic sensitivity of the organisms. Results: One hundred and forty one patients with positive culture for Acinetobacter spp. were identified. Soft tissue/wound and respiratory tract were among the commonest sites of Acinetobacter spp. isolation. The isolates were most frequently obtained from ICU. All isolates were multi-drug resistant and had a resistance rate of more than 70% to most antibiotics, except polymyxin B. Conclusion: High prevalence of multi-drug resistance Acinetobacter spp. provides essential information on judicious antibiotic selection for empirical therapy in our health-care institution.

KW - Acinetobacter spp.

KW - Antimicrobial susceptibility

KW - Intensive care unit

KW - Polymyxin B

UR - http://www.scopus.com/inward/record.url?scp=84875119342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875119342&partnerID=8YFLogxK

M3 - Article

VL - 29

JO - Pakistan Journal of Medical Sciences

JF - Pakistan Journal of Medical Sciences

SN - 1682-024X

IS - 2

ER -