Clinical significance of SLC2A9/GLUT9 rs11722228 polymorphisms in gout

Esha Das Gupta, Sakthiswary Rajalingham, Shing L. Lee, Shew F. Wong, Heselynn Hussein, Suk C. Gun

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: The main objective of this study is to elucidate the clinical significance of the SLC2A9/GLUT9 rs11722228 polymorphism among male gout patients. Method: We consecutively recruited all newly diagnosed male gout patients who were treatment-naive from the rheumatology outpatient clinics of two Malaysian hospitals. Age-matched healthy male adults were employed as controls. All subjects were tested for the SLC2A9/GLUT9 rs11722228 genotypes, serum uric acid (SUA), urine uric acid and creatinine levels. All gout subjects were examined for the presence of tophi and sonographically screened for renal calculi. Results: A total of 73 male gout patients and 73 age-matched healthy male adults were recruited in this study. The genotypic frequencies of SLC2A9/GLUT9 rs1172228 did not differ significantly between the gout cases and the healthy controls. The gout subjects with the CC genotype had significantly higher SUA levels (P = 0.002), family history of gout (P < 0.050) and the occurrence of renal calculi (P = 0.026). The SUA-adjusted odds ratios (OR) of the occurrence of renal calculi in the CC genotype (OR = 1 [reference]) was significantly higher than the CT genotype (OR = 0.338, 95%CI: 0.141-0.813) and the TT genotype (OR = 0.271, 95%CI: 0.086-0.854). Conclusions: The genotypic distribution of SLC2A9/GLUT9 rs1172228 in male gout patients did not differ significantly from that of healthy male controls. However, the CC genotype in gout had significant associations with higher levels of SUA, renal calculi and a positive family history of gout.

Original languageEnglish
JournalInternational Journal of Rheumatic Diseases
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Gout
Uric Acid
Kidney Calculi
Genotype
Odds Ratio
Serum
Rheumatology
Ambulatory Care Facilities
Creatinine
Urine

Keywords

  • Genotypes
  • Gout
  • SLC2A9/GLUT9 rs1172228

ASJC Scopus subject areas

  • Rheumatology

Cite this

Clinical significance of SLC2A9/GLUT9 rs11722228 polymorphisms in gout. / Das Gupta, Esha; Rajalingham, Sakthiswary; Lee, Shing L.; Wong, Shew F.; Hussein, Heselynn; Gun, Suk C.

In: International Journal of Rheumatic Diseases, 2016.

Research output: Contribution to journalArticle

Das Gupta, Esha ; Rajalingham, Sakthiswary ; Lee, Shing L. ; Wong, Shew F. ; Hussein, Heselynn ; Gun, Suk C. / Clinical significance of SLC2A9/GLUT9 rs11722228 polymorphisms in gout. In: International Journal of Rheumatic Diseases. 2016.
@article{020d18776d8b4b058f7cd9760b7025cb,
title = "Clinical significance of SLC2A9/GLUT9 rs11722228 polymorphisms in gout",
abstract = "Aim: The main objective of this study is to elucidate the clinical significance of the SLC2A9/GLUT9 rs11722228 polymorphism among male gout patients. Method: We consecutively recruited all newly diagnosed male gout patients who were treatment-naive from the rheumatology outpatient clinics of two Malaysian hospitals. Age-matched healthy male adults were employed as controls. All subjects were tested for the SLC2A9/GLUT9 rs11722228 genotypes, serum uric acid (SUA), urine uric acid and creatinine levels. All gout subjects were examined for the presence of tophi and sonographically screened for renal calculi. Results: A total of 73 male gout patients and 73 age-matched healthy male adults were recruited in this study. The genotypic frequencies of SLC2A9/GLUT9 rs1172228 did not differ significantly between the gout cases and the healthy controls. The gout subjects with the CC genotype had significantly higher SUA levels (P = 0.002), family history of gout (P < 0.050) and the occurrence of renal calculi (P = 0.026). The SUA-adjusted odds ratios (OR) of the occurrence of renal calculi in the CC genotype (OR = 1 [reference]) was significantly higher than the CT genotype (OR = 0.338, 95{\%}CI: 0.141-0.813) and the TT genotype (OR = 0.271, 95{\%}CI: 0.086-0.854). Conclusions: The genotypic distribution of SLC2A9/GLUT9 rs1172228 in male gout patients did not differ significantly from that of healthy male controls. However, the CC genotype in gout had significant associations with higher levels of SUA, renal calculi and a positive family history of gout.",
keywords = "Genotypes, Gout, SLC2A9/GLUT9 rs1172228",
author = "{Das Gupta}, Esha and Sakthiswary Rajalingham and Lee, {Shing L.} and Wong, {Shew F.} and Heselynn Hussein and Gun, {Suk C.}",
year = "2016",
doi = "10.1111/1756-185X.12918",
language = "English",
journal = "International Journal of Rheumatic Diseases",
issn = "1756-1841",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Clinical significance of SLC2A9/GLUT9 rs11722228 polymorphisms in gout

AU - Das Gupta, Esha

AU - Rajalingham, Sakthiswary

AU - Lee, Shing L.

AU - Wong, Shew F.

AU - Hussein, Heselynn

AU - Gun, Suk C.

PY - 2016

Y1 - 2016

N2 - Aim: The main objective of this study is to elucidate the clinical significance of the SLC2A9/GLUT9 rs11722228 polymorphism among male gout patients. Method: We consecutively recruited all newly diagnosed male gout patients who were treatment-naive from the rheumatology outpatient clinics of two Malaysian hospitals. Age-matched healthy male adults were employed as controls. All subjects were tested for the SLC2A9/GLUT9 rs11722228 genotypes, serum uric acid (SUA), urine uric acid and creatinine levels. All gout subjects were examined for the presence of tophi and sonographically screened for renal calculi. Results: A total of 73 male gout patients and 73 age-matched healthy male adults were recruited in this study. The genotypic frequencies of SLC2A9/GLUT9 rs1172228 did not differ significantly between the gout cases and the healthy controls. The gout subjects with the CC genotype had significantly higher SUA levels (P = 0.002), family history of gout (P < 0.050) and the occurrence of renal calculi (P = 0.026). The SUA-adjusted odds ratios (OR) of the occurrence of renal calculi in the CC genotype (OR = 1 [reference]) was significantly higher than the CT genotype (OR = 0.338, 95%CI: 0.141-0.813) and the TT genotype (OR = 0.271, 95%CI: 0.086-0.854). Conclusions: The genotypic distribution of SLC2A9/GLUT9 rs1172228 in male gout patients did not differ significantly from that of healthy male controls. However, the CC genotype in gout had significant associations with higher levels of SUA, renal calculi and a positive family history of gout.

AB - Aim: The main objective of this study is to elucidate the clinical significance of the SLC2A9/GLUT9 rs11722228 polymorphism among male gout patients. Method: We consecutively recruited all newly diagnosed male gout patients who were treatment-naive from the rheumatology outpatient clinics of two Malaysian hospitals. Age-matched healthy male adults were employed as controls. All subjects were tested for the SLC2A9/GLUT9 rs11722228 genotypes, serum uric acid (SUA), urine uric acid and creatinine levels. All gout subjects were examined for the presence of tophi and sonographically screened for renal calculi. Results: A total of 73 male gout patients and 73 age-matched healthy male adults were recruited in this study. The genotypic frequencies of SLC2A9/GLUT9 rs1172228 did not differ significantly between the gout cases and the healthy controls. The gout subjects with the CC genotype had significantly higher SUA levels (P = 0.002), family history of gout (P < 0.050) and the occurrence of renal calculi (P = 0.026). The SUA-adjusted odds ratios (OR) of the occurrence of renal calculi in the CC genotype (OR = 1 [reference]) was significantly higher than the CT genotype (OR = 0.338, 95%CI: 0.141-0.813) and the TT genotype (OR = 0.271, 95%CI: 0.086-0.854). Conclusions: The genotypic distribution of SLC2A9/GLUT9 rs1172228 in male gout patients did not differ significantly from that of healthy male controls. However, the CC genotype in gout had significant associations with higher levels of SUA, renal calculi and a positive family history of gout.

KW - Genotypes

KW - Gout

KW - SLC2A9/GLUT9 rs1172228

UR - http://www.scopus.com/inward/record.url?scp=84994607551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994607551&partnerID=8YFLogxK

U2 - 10.1111/1756-185X.12918

DO - 10.1111/1756-185X.12918

M3 - Article

JO - International Journal of Rheumatic Diseases

JF - International Journal of Rheumatic Diseases

SN - 1756-1841

ER -