Clinical features and risk factors for HIV encephalopathy in children

Mohd Zaini Abd Hamid, Noorazah Abd Aziz, Syed Zulkifli Syed Zakaria, O. Norlijah, R. Kamarul Azhar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A prospective cohort study was conducted to determine the incidence of progressive encephalopathy (PE) and its associated clinical manifestations amongst a cohort of HIV infected children attending the HIV/AIDS clinic of the Pediatric Institute, Kuala Lumpur Hospital, Malaysia. Neurological and neurobehavioral assessments were performed in 55 children with HIV over a 24-month study period. Parameters assessed were physical and neurological assessments, CD4 counts, CD4 percentages, RNA viral loads and an IQ assessment at four monthly intervals. PE was diagnosed when patient developed at least one of the definitive criteria for PE based on the Consensus of Pediatric Neurology / Psychology Working Group, AIDS Clinical Trial 1996. The incidence of encephalopathy was 18.2% (n=10) in 2002. All the patients had hepatosplenomegaly, lymphadenopathy, abnormal deep tendon reflexes and five had impairment in brain growth. The CD4 counts and CD4 percentages were more likely to be associated with PE compared to the non-PE group.

Original languageEnglish
Pages (from-to)266-272
Number of pages7
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Volume39
Issue number2
Publication statusPublished - Mar 2008

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AIDS Dementia Complex
Brain Diseases
HIV
CD4 Lymphocyte Count
Acquired Immunodeficiency Syndrome
Child Psychology
Abnormal Reflexes
Malaysia
Incidence
Neurology
Viral Load
Consensus
Cohort Studies
Clinical Trials
Prospective Studies
RNA
Pediatrics
Brain
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical features and risk factors for HIV encephalopathy in children. / Hamid, Mohd Zaini Abd; Abd Aziz, Noorazah; Syed Zakaria, Syed Zulkifli; Norlijah, O.; Kamarul Azhar, R.

In: Southeast Asian Journal of Tropical Medicine and Public Health, Vol. 39, No. 2, 03.2008, p. 266-272.

Research output: Contribution to journalArticle

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