Abstract
Introduction: Rheumatoid arthritis (RA) is a systemic disease of unknown cause. A variety of pulmonary disorders have been described in association with RA. Among the most common are interstitial lung disease (ILD) and bronchiectasis. Objectives: This study aims to determine the characteristics of RA patients with lung disease in relation to clinical characteristics, pulmonary function test (PFT) and high resolution computed tomography (HRCT) thorax. Method: This is a 6-months cross-sectional study involving 63 consecutive RA patients in an outpatient rheumatology clinic. Patients had a mean disease duration of 5 years and above. Disease activity and severity was assessed by Disease Activity Score 28 (DAS28), Health Assessment Questionnaire (HAQ) and Rheumatoid Arthritis Articular Damage (RAAD) score. Full pulmonary function test (PFT) and HRCT of thorax were performed. Conclusions: The prevalence of RA-ILD is 44% and 67% of patients are asymptomatic. There was significant higher proportion (68%) in patients of Chinese ethnicity who have ILD. Diffusion capacity of carbon monoxide was abnormal in all patients and forced expiratory flow (FEF) 25-75% was low in 16%. Restrictive pattern was 66.7% by PFT. The most common HRCT findings were reticulation (46%) followed by ground glass opacities (38.1%) and bronchiectasis (28.6%). There was no association between ILD and male gender, duration of the disease, smoking, rheumatoid factor, extra-articular manifestations, disease activity or severity.
| Original language | English |
|---|---|
| Pages (from-to) | 136-144 |
| Number of pages | 9 |
| Journal | International Journal of Rheumatic Diseases |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- High resolution computed tomography
- Interstitial lung disease
- Lung function test
- Rheumatoid arthritis
ASJC Scopus subject areas
- Rheumatology
Cite this
Clinical and high resolution computed tomography characteristics of patients with rheumatoid arthritis lung disease. / Mohd Noor, Nadiah; Mohamed Said, Mohd Shahrir; Shahid, Mohd Shahdan; Abd. Manap, Roslina; Shahizon Azura, Ahmad Mukari; Shah, Shamsul Azhar.
In: International Journal of Rheumatic Diseases, Vol. 12, No. 2, 2009, p. 136-144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and high resolution computed tomography characteristics of patients with rheumatoid arthritis lung disease
AU - Mohd Noor, Nadiah
AU - Mohamed Said, Mohd Shahrir
AU - Shahid, Mohd Shahdan
AU - Abd. Manap, Roslina
AU - Shahizon Azura, Ahmad Mukari
AU - Shah, Shamsul Azhar
PY - 2009
Y1 - 2009
N2 - Introduction: Rheumatoid arthritis (RA) is a systemic disease of unknown cause. A variety of pulmonary disorders have been described in association with RA. Among the most common are interstitial lung disease (ILD) and bronchiectasis. Objectives: This study aims to determine the characteristics of RA patients with lung disease in relation to clinical characteristics, pulmonary function test (PFT) and high resolution computed tomography (HRCT) thorax. Method: This is a 6-months cross-sectional study involving 63 consecutive RA patients in an outpatient rheumatology clinic. Patients had a mean disease duration of 5 years and above. Disease activity and severity was assessed by Disease Activity Score 28 (DAS28), Health Assessment Questionnaire (HAQ) and Rheumatoid Arthritis Articular Damage (RAAD) score. Full pulmonary function test (PFT) and HRCT of thorax were performed. Conclusions: The prevalence of RA-ILD is 44% and 67% of patients are asymptomatic. There was significant higher proportion (68%) in patients of Chinese ethnicity who have ILD. Diffusion capacity of carbon monoxide was abnormal in all patients and forced expiratory flow (FEF) 25-75% was low in 16%. Restrictive pattern was 66.7% by PFT. The most common HRCT findings were reticulation (46%) followed by ground glass opacities (38.1%) and bronchiectasis (28.6%). There was no association between ILD and male gender, duration of the disease, smoking, rheumatoid factor, extra-articular manifestations, disease activity or severity.
AB - Introduction: Rheumatoid arthritis (RA) is a systemic disease of unknown cause. A variety of pulmonary disorders have been described in association with RA. Among the most common are interstitial lung disease (ILD) and bronchiectasis. Objectives: This study aims to determine the characteristics of RA patients with lung disease in relation to clinical characteristics, pulmonary function test (PFT) and high resolution computed tomography (HRCT) thorax. Method: This is a 6-months cross-sectional study involving 63 consecutive RA patients in an outpatient rheumatology clinic. Patients had a mean disease duration of 5 years and above. Disease activity and severity was assessed by Disease Activity Score 28 (DAS28), Health Assessment Questionnaire (HAQ) and Rheumatoid Arthritis Articular Damage (RAAD) score. Full pulmonary function test (PFT) and HRCT of thorax were performed. Conclusions: The prevalence of RA-ILD is 44% and 67% of patients are asymptomatic. There was significant higher proportion (68%) in patients of Chinese ethnicity who have ILD. Diffusion capacity of carbon monoxide was abnormal in all patients and forced expiratory flow (FEF) 25-75% was low in 16%. Restrictive pattern was 66.7% by PFT. The most common HRCT findings were reticulation (46%) followed by ground glass opacities (38.1%) and bronchiectasis (28.6%). There was no association between ILD and male gender, duration of the disease, smoking, rheumatoid factor, extra-articular manifestations, disease activity or severity.
KW - High resolution computed tomography
KW - Interstitial lung disease
KW - Lung function test
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=67749097835&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67749097835&partnerID=8YFLogxK
U2 - 10.1111/j.1756-185X.2009.01376.x
DO - 10.1111/j.1756-185X.2009.01376.x
M3 - Article
VL - 12
SP - 136
EP - 144
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
SN - 1756-1841
IS - 2
ER -