Citrus leaf extract reduces blood pressure and vascular damage in repeatedly heated palm oil diet-Induced hypertensive rats

Hawa Nordin Siti, Kamisah Yusof, Mohd Ishak Nur Iliyani, Suhaila Mohamed, Kamsiah Jaarin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Prolonged consumption of repeatedly heated vegetable oil increases blood pressure. This study aimed to determine the effects of Citrus leaf extract, (CLE) on blood pressure, blood pressure-regulating enzymes and mediators, as well as aortic histomorphometry in heated palm oil induced-hypertension. Male Sprague Dawley rats (n = 56) were divided into seven groups; control group was given normal diet and the other groups were fed with palm oil-enriched diet (15% w/w) either fresh (FPO), five-time-heated (5HPO) or ten-time-heated (10HPO) with or without CLE (0.15%, w/w) supplementation. CLE supplementation reduced the heated oil-raising effect of blood pressure, plasma TBARS, thromboxane and angiotensin-1 converting enzyme in 5HPO but not in 10HPO group. CLE increased serum heme oxygenase-1 in both 5HPO and 10HPO groups. CLE supplementation reduced the increase in aortic intima-media thickness, intima-media area and circumferential wall tension in 5HPO group but not in 10HPO group. These findings suggested that CLE supplementation reduces the blood pressure-raising effects of 5HPO and vascular damage, possibly through its antioxidant effect by modulating vasoactive mediators and blood pressure-regulating enzymes.

Original languageEnglish
Pages (from-to)451-460
Number of pages10
JournalBiomedicine and Pharmacotherapy
Volume87
DOIs
Publication statusPublished - 1 Mar 2017

Fingerprint

Citrus
Blood Vessels
Diet
Blood Pressure
Heme Oxygenase-1
Plant Oils
Thromboxanes
Peptidyl-Dipeptidase A
Enzymes
Sprague Dawley Rats
palm oil
Oils
Antioxidants
Hypertension
Control Groups
Serum

Keywords

  • Citrus
  • Oxidative stress
  • Rutaceae
  • Vascular remodeling
  • Vasoactive mediators

ASJC Scopus subject areas

  • Pharmacology

Cite this

Citrus leaf extract reduces blood pressure and vascular damage in repeatedly heated palm oil diet-Induced hypertensive rats. / Siti, Hawa Nordin; Yusof, Kamisah; Nur Iliyani, Mohd Ishak; Mohamed, Suhaila; Jaarin, Kamsiah.

In: Biomedicine and Pharmacotherapy, Vol. 87, 01.03.2017, p. 451-460.

Research output: Contribution to journalArticle

Siti, Hawa Nordin ; Yusof, Kamisah ; Nur Iliyani, Mohd Ishak ; Mohamed, Suhaila ; Jaarin, Kamsiah. / Citrus leaf extract reduces blood pressure and vascular damage in repeatedly heated palm oil diet-Induced hypertensive rats. In: Biomedicine and Pharmacotherapy. 2017 ; Vol. 87. pp. 451-460.
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