Citrus leaf extract reduces blood pressure and vascular damage in repeatedly heated palm oil diet-Induced hypertensive rats

Hawa Nordin Siti, Kamisah Yusof, Mohd Ishak Nur Iliyani, Suhaila Mohamed, Kamsiah Jaarin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Prolonged consumption of repeatedly heated vegetable oil increases blood pressure. This study aimed to determine the effects of Citrus leaf extract, (CLE) on blood pressure, blood pressure-regulating enzymes and mediators, as well as aortic histomorphometry in heated palm oil induced-hypertension. Male Sprague Dawley rats (n = 56) were divided into seven groups; control group was given normal diet and the other groups were fed with palm oil-enriched diet (15% w/w) either fresh (FPO), five-time-heated (5HPO) or ten-time-heated (10HPO) with or without CLE (0.15%, w/w) supplementation. CLE supplementation reduced the heated oil-raising effect of blood pressure, plasma TBARS, thromboxane and angiotensin-1 converting enzyme in 5HPO but not in 10HPO group. CLE increased serum heme oxygenase-1 in both 5HPO and 10HPO groups. CLE supplementation reduced the increase in aortic intima-media thickness, intima-media area and circumferential wall tension in 5HPO group but not in 10HPO group. These findings suggested that CLE supplementation reduces the blood pressure-raising effects of 5HPO and vascular damage, possibly through its antioxidant effect by modulating vasoactive mediators and blood pressure-regulating enzymes.

Original languageEnglish
Pages (from-to)451-460
Number of pages10
JournalBiomedicine and Pharmacotherapy
Volume87
DOIs
Publication statusPublished - 1 Mar 2017

Fingerprint

Citrus
Blood Vessels
Diet
Blood Pressure
Heme Oxygenase-1
Plant Oils
Thromboxanes
Peptidyl-Dipeptidase A
Enzymes
Sprague Dawley Rats
palm oil
Oils
Antioxidants
Hypertension
Control Groups
Serum

Keywords

  • Citrus
  • Oxidative stress
  • Rutaceae
  • Vascular remodeling
  • Vasoactive mediators

ASJC Scopus subject areas

  • Pharmacology

Cite this

Citrus leaf extract reduces blood pressure and vascular damage in repeatedly heated palm oil diet-Induced hypertensive rats. / Siti, Hawa Nordin; Yusof, Kamisah; Nur Iliyani, Mohd Ishak; Mohamed, Suhaila; Jaarin, Kamsiah.

In: Biomedicine and Pharmacotherapy, Vol. 87, 01.03.2017, p. 451-460.

Research output: Contribution to journalArticle

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