Circulating pancreatic polypeptide concentrations predict visceral and liver fat content

Amir H. Sam, Michelle L. Sleeth, E. Louise Thomas, Nurhafzan A. Ismail, Norlida Mat Daud @ Daud, Edward Chambers, Fariba Shojaee-Moradie, Margot Umpleby, Anthony P. Goldstone, Carel W. Le Roux, Paul Bech, Mark Busbridge, Rosemary Laurie, Daniel J. Cuthbertson, Adam Buckley, Mohammad A. Ghatei, Stephen R. Bloom, Gary S. Frost, Jimmy D. Bell, Kevin G. Murphy

Research output: Contribution to journalArticle

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Abstract

Context and objective: Nocurrent biomarker can reliably predict visceral and liver fat content, both of which are risk factors for cardiovascular disease. Vagal tone has been suggested to influence regional fat deposition. Pancreatic polypeptide (PP) is secreted from the endocrine pancreas under vagal control. We investigated the utility of PP in predicting visceral and liver fat. Patients and Methods: Fasting plasma PP concentrations were measured in 104 overweight and obese subjects (46 men and 58 women). In the same subjects, total and regional adipose tissue, including total visceral adipose tissue (VAT) and total subcutaneous adipose tissue (TSAT), were measured using whole-body magnetic resonance imaging. Intrahepatocellular lipid content (IHCL) was quantified by proton magnetic resonance spectroscopy. Results: Fasting plasma PP concentrations positively and significantly correlated with both VAT (r =0.57, P < .001) and IHCL (r = 0.51, P < .001), but not with TSAT (r = 0.02, P = .88). Fasting PP concentrations independently predicted VAT after controlling for age and sex. Fasting PP concentrations independently predicted IHCL after controlling for age, sex, body mass index (BMI), waist-to-hip ratio, homeostatic model assessment 2-insulin resistance, (HOMA2-IR) and serum concentrations of triglyceride (TG), total cholesterol (TC), and alanine aminotransferase (ALT). Fasting PP concentrations were associated with serum ALT, TG, TC, low- and high-density lipoprotein cholesterol, and blood pressure (P < .05). These associations were mediated by IHCL and/or VAT. Fasting PP and HOMA2-IR were independently significantly associated with hepatic steatosis (P < .01). Conclusions: Pancreatic polypeptide is a novel predictor of visceral and liver fat content, and thus a potential biomarker for cardiovascular risk stratification and targeted treatment of patients with ectopic fat deposition.

Original languageEnglish
Pages (from-to)1048-1052
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number3
DOIs
Publication statusPublished - 1 Mar 2015

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Pancreatic Polypeptide
Intra-Abdominal Fat
Liver
Fats
Fasting
Tissue
Lipids
Subcutaneous Fat
Biomarkers
Alanine Transaminase
Insulin Resistance
Triglycerides
Cholesterol
Magnetic resonance spectroscopy
Insulin
Plasmas
Waist-Hip Ratio
Blood pressure
Magnetic resonance
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Circulating pancreatic polypeptide concentrations predict visceral and liver fat content. / Sam, Amir H.; Sleeth, Michelle L.; Thomas, E. Louise; Ismail, Nurhafzan A.; Mat Daud @ Daud, Norlida; Chambers, Edward; Shojaee-Moradie, Fariba; Umpleby, Margot; Goldstone, Anthony P.; Le Roux, Carel W.; Bech, Paul; Busbridge, Mark; Laurie, Rosemary; Cuthbertson, Daniel J.; Buckley, Adam; Ghatei, Mohammad A.; Bloom, Stephen R.; Frost, Gary S.; Bell, Jimmy D.; Murphy, Kevin G.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 3, 01.03.2015, p. 1048-1052.

Research output: Contribution to journalArticle

Sam, AH, Sleeth, ML, Thomas, EL, Ismail, NA, Mat Daud @ Daud, N, Chambers, E, Shojaee-Moradie, F, Umpleby, M, Goldstone, AP, Le Roux, CW, Bech, P, Busbridge, M, Laurie, R, Cuthbertson, DJ, Buckley, A, Ghatei, MA, Bloom, SR, Frost, GS, Bell, JD & Murphy, KG 2015, 'Circulating pancreatic polypeptide concentrations predict visceral and liver fat content', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 3, pp. 1048-1052. https://doi.org/10.1210/jc.2014-3450
Sam, Amir H. ; Sleeth, Michelle L. ; Thomas, E. Louise ; Ismail, Nurhafzan A. ; Mat Daud @ Daud, Norlida ; Chambers, Edward ; Shojaee-Moradie, Fariba ; Umpleby, Margot ; Goldstone, Anthony P. ; Le Roux, Carel W. ; Bech, Paul ; Busbridge, Mark ; Laurie, Rosemary ; Cuthbertson, Daniel J. ; Buckley, Adam ; Ghatei, Mohammad A. ; Bloom, Stephen R. ; Frost, Gary S. ; Bell, Jimmy D. ; Murphy, Kevin G. / Circulating pancreatic polypeptide concentrations predict visceral and liver fat content. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 3. pp. 1048-1052.
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abstract = "Context and objective: Nocurrent biomarker can reliably predict visceral and liver fat content, both of which are risk factors for cardiovascular disease. Vagal tone has been suggested to influence regional fat deposition. Pancreatic polypeptide (PP) is secreted from the endocrine pancreas under vagal control. We investigated the utility of PP in predicting visceral and liver fat. Patients and Methods: Fasting plasma PP concentrations were measured in 104 overweight and obese subjects (46 men and 58 women). In the same subjects, total and regional adipose tissue, including total visceral adipose tissue (VAT) and total subcutaneous adipose tissue (TSAT), were measured using whole-body magnetic resonance imaging. Intrahepatocellular lipid content (IHCL) was quantified by proton magnetic resonance spectroscopy. Results: Fasting plasma PP concentrations positively and significantly correlated with both VAT (r =0.57, P < .001) and IHCL (r = 0.51, P < .001), but not with TSAT (r = 0.02, P = .88). Fasting PP concentrations independently predicted VAT after controlling for age and sex. Fasting PP concentrations independently predicted IHCL after controlling for age, sex, body mass index (BMI), waist-to-hip ratio, homeostatic model assessment 2-insulin resistance, (HOMA2-IR) and serum concentrations of triglyceride (TG), total cholesterol (TC), and alanine aminotransferase (ALT). Fasting PP concentrations were associated with serum ALT, TG, TC, low- and high-density lipoprotein cholesterol, and blood pressure (P < .05). These associations were mediated by IHCL and/or VAT. Fasting PP and HOMA2-IR were independently significantly associated with hepatic steatosis (P < .01). Conclusions: Pancreatic polypeptide is a novel predictor of visceral and liver fat content, and thus a potential biomarker for cardiovascular risk stratification and targeted treatment of patients with ectopic fat deposition.",
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T1 - Circulating pancreatic polypeptide concentrations predict visceral and liver fat content

AU - Sam, Amir H.

AU - Sleeth, Michelle L.

AU - Thomas, E. Louise

AU - Ismail, Nurhafzan A.

AU - Mat Daud @ Daud, Norlida

AU - Chambers, Edward

AU - Shojaee-Moradie, Fariba

AU - Umpleby, Margot

AU - Goldstone, Anthony P.

AU - Le Roux, Carel W.

AU - Bech, Paul

AU - Busbridge, Mark

AU - Laurie, Rosemary

AU - Cuthbertson, Daniel J.

AU - Buckley, Adam

AU - Ghatei, Mohammad A.

AU - Bloom, Stephen R.

AU - Frost, Gary S.

AU - Bell, Jimmy D.

AU - Murphy, Kevin G.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Context and objective: Nocurrent biomarker can reliably predict visceral and liver fat content, both of which are risk factors for cardiovascular disease. Vagal tone has been suggested to influence regional fat deposition. Pancreatic polypeptide (PP) is secreted from the endocrine pancreas under vagal control. We investigated the utility of PP in predicting visceral and liver fat. Patients and Methods: Fasting plasma PP concentrations were measured in 104 overweight and obese subjects (46 men and 58 women). In the same subjects, total and regional adipose tissue, including total visceral adipose tissue (VAT) and total subcutaneous adipose tissue (TSAT), were measured using whole-body magnetic resonance imaging. Intrahepatocellular lipid content (IHCL) was quantified by proton magnetic resonance spectroscopy. Results: Fasting plasma PP concentrations positively and significantly correlated with both VAT (r =0.57, P < .001) and IHCL (r = 0.51, P < .001), but not with TSAT (r = 0.02, P = .88). Fasting PP concentrations independently predicted VAT after controlling for age and sex. Fasting PP concentrations independently predicted IHCL after controlling for age, sex, body mass index (BMI), waist-to-hip ratio, homeostatic model assessment 2-insulin resistance, (HOMA2-IR) and serum concentrations of triglyceride (TG), total cholesterol (TC), and alanine aminotransferase (ALT). Fasting PP concentrations were associated with serum ALT, TG, TC, low- and high-density lipoprotein cholesterol, and blood pressure (P < .05). These associations were mediated by IHCL and/or VAT. Fasting PP and HOMA2-IR were independently significantly associated with hepatic steatosis (P < .01). Conclusions: Pancreatic polypeptide is a novel predictor of visceral and liver fat content, and thus a potential biomarker for cardiovascular risk stratification and targeted treatment of patients with ectopic fat deposition.

AB - Context and objective: Nocurrent biomarker can reliably predict visceral and liver fat content, both of which are risk factors for cardiovascular disease. Vagal tone has been suggested to influence regional fat deposition. Pancreatic polypeptide (PP) is secreted from the endocrine pancreas under vagal control. We investigated the utility of PP in predicting visceral and liver fat. Patients and Methods: Fasting plasma PP concentrations were measured in 104 overweight and obese subjects (46 men and 58 women). In the same subjects, total and regional adipose tissue, including total visceral adipose tissue (VAT) and total subcutaneous adipose tissue (TSAT), were measured using whole-body magnetic resonance imaging. Intrahepatocellular lipid content (IHCL) was quantified by proton magnetic resonance spectroscopy. Results: Fasting plasma PP concentrations positively and significantly correlated with both VAT (r =0.57, P < .001) and IHCL (r = 0.51, P < .001), but not with TSAT (r = 0.02, P = .88). Fasting PP concentrations independently predicted VAT after controlling for age and sex. Fasting PP concentrations independently predicted IHCL after controlling for age, sex, body mass index (BMI), waist-to-hip ratio, homeostatic model assessment 2-insulin resistance, (HOMA2-IR) and serum concentrations of triglyceride (TG), total cholesterol (TC), and alanine aminotransferase (ALT). Fasting PP concentrations were associated with serum ALT, TG, TC, low- and high-density lipoprotein cholesterol, and blood pressure (P < .05). These associations were mediated by IHCL and/or VAT. Fasting PP and HOMA2-IR were independently significantly associated with hepatic steatosis (P < .01). Conclusions: Pancreatic polypeptide is a novel predictor of visceral and liver fat content, and thus a potential biomarker for cardiovascular risk stratification and targeted treatment of patients with ectopic fat deposition.

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