Circulating levels of GH-releasing hormone and GH during human pregnancy

M. Mazlan, C. Spence-Jones, T. Chard, J. Landon, C. McLean

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To study the potential role of GH-releasing hormone (GHRH) in maintaining circulating levels of GH during pregnancy, 302 maternal plasma samples were collected from non-fasted subjects at various stages of pregnancy and assayed from GHRH using a 'two-site' immunoradiometric assay. The GH and placental lactogen levels were also determined. In addition, maternal plasma samples taken during labour, amniotic fluid and cord blood were also assayed for these hormones. Maternal plasma GHRH levels were similar to non-pregnant levels throughout gestation despite fluctuations in GH values which were always higher than non-pregnant levels. There was no significant difference between GHRH levels in maternal plasma and cord blood although high GH levels were observed in the latter. These findings suggest that peripheral GHRH levels do not play an important role in maintaining circulating GH levels during pregnancy.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalJournal of Endocrinology
Volume125
Issue number1
Publication statusPublished - 1990
Externally publishedYes

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Hormones
Pregnancy
Mothers
Fetal Blood
Placental Lactogen
Immunoradiometric Assay
Amniotic Fluid

ASJC Scopus subject areas

  • Endocrinology

Cite this

Mazlan, M., Spence-Jones, C., Chard, T., Landon, J., & McLean, C. (1990). Circulating levels of GH-releasing hormone and GH during human pregnancy. Journal of Endocrinology, 125(1), 161-167.

Circulating levels of GH-releasing hormone and GH during human pregnancy. / Mazlan, M.; Spence-Jones, C.; Chard, T.; Landon, J.; McLean, C.

In: Journal of Endocrinology, Vol. 125, No. 1, 1990, p. 161-167.

Research output: Contribution to journalArticle

Mazlan, M, Spence-Jones, C, Chard, T, Landon, J & McLean, C 1990, 'Circulating levels of GH-releasing hormone and GH during human pregnancy', Journal of Endocrinology, vol. 125, no. 1, pp. 161-167.
Mazlan M, Spence-Jones C, Chard T, Landon J, McLean C. Circulating levels of GH-releasing hormone and GH during human pregnancy. Journal of Endocrinology. 1990;125(1):161-167.
Mazlan, M. ; Spence-Jones, C. ; Chard, T. ; Landon, J. ; McLean, C. / Circulating levels of GH-releasing hormone and GH during human pregnancy. In: Journal of Endocrinology. 1990 ; Vol. 125, No. 1. pp. 161-167.
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