Circular RNAs as promising biomarkers: A mini-review

Research output: Contribution to journalShort survey

38 Citations (Scopus)

Abstract

The interest in circular RNAs has resurfaced in the past few years. What was considered as "junk" for nearly two decades is now one of the most interesting molecules. Circular RNAs are non-coding RNAs that are formed by back-splicing events and have covalently closed loops with no poly-adenylated tails. The regulation of circular RNAs is distinctive and they are selectively abundant in different types of tissues. Based on the current knowledge of circular RNAs, these molecules have the potential to be the "next big thing" especially as biomarkers for different diseases. This mini-review attempts to concisely look at the biology of circular RNAs, the putative functional activities, the prevalence of circular RNAs, and the possible role of circular RNA as biomarkers for diagnosis or measuring drug response.

Original languageEnglish
Article number355
JournalFrontiers in Physiology
Volume7
Issue numberAUG
DOIs
Publication statusPublished - 18 Aug 2016

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Biomarkers
Untranslated RNA
circular RNA
Pharmaceutical Preparations

Keywords

  • Biomarker
  • Cancer
  • Circular RNAs
  • Targeted therapies

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Circular RNAs as promising biomarkers : A mini-review. / Abu, Nadiah; A. Jamal, A. Rahman.

In: Frontiers in Physiology, Vol. 7, No. AUG, 355, 18.08.2016.

Research output: Contribution to journalShort survey

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