Chronic nephrotoxicity of anti-inflammatory drugs used in the treatment of arthritis

M. Segasothy, G. L. Chin, K. K. Sia, A. Zulfiqar, S. A. Samad

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    We determined the consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of chronic renal impairment and renal papillary necrosis (RPN) in patients with various types of arthritis. Ninety-four patients with chronic arthritis who had consumed more than 1000 capsules and/or tablets of NSAIDs were studied. Renal profiles and radiological investigations such as intravenous urogram (IVU), ultrasonography (US) and computed tomography (CT) were performed to look for evidence of RPN. Twelve patients did not complete the study. Ten of the 82 patients who had completed the study (12.2%) had radiologic evidence of RPN. Five out of 53 patients (9.4%) with rheumatoid arthritis, three out of 11 patients (27.3%) with gouty arthritis and two out of seven patients (28.6%) with osteoarthritis had RPN. Renal impairment (serum creatinine levels of 125-451 μmol/l) was found in 20 patients (24.4%). The patients had consumed 3000-26 300 capsules and/or tablets over a period ranging from 1 yr to more than 30 yr. Patients with chronic arthritis who consume excessive amount of NSAIDs are at risk of developing RPN and chronic renal impairment.

    Original languageEnglish
    Pages (from-to)162-165
    Number of pages4
    JournalBritish Journal of Rheumatology
    Volume34
    Issue number2
    Publication statusPublished - 1995

    Fingerprint

    Ultrasonography
    Arthritis
    Necrosis
    arthritis
    Tomography
    Drugs
    drugs
    Anti-Inflammatory Agents
    Kidney
    necrosis
    Pharmaceutical Preparations
    impairment
    Osteoarthritis
    Therapeutics
    tablets
    Rheumatoid Arthritis
    Computed Tomography
    capsules
    Tablets
    Capsules

    Keywords

    • Arthritis
    • Chronic renal impairment
    • Non-steroidal anti-inflammatory drugs
    • Renal papillary necrosis

    ASJC Scopus subject areas

    • Rheumatology
    • Neuroscience(all)
    • Molecular Biology
    • Statistics and Probability
    • Computational Mathematics
    • Condensed Matter Physics
    • Applied Mathematics
    • Pharmacology (medical)

    Cite this

    Segasothy, M., Chin, G. L., Sia, K. K., Zulfiqar, A., & Samad, S. A. (1995). Chronic nephrotoxicity of anti-inflammatory drugs used in the treatment of arthritis. British Journal of Rheumatology, 34(2), 162-165.

    Chronic nephrotoxicity of anti-inflammatory drugs used in the treatment of arthritis. / Segasothy, M.; Chin, G. L.; Sia, K. K.; Zulfiqar, A.; Samad, S. A.

    In: British Journal of Rheumatology, Vol. 34, No. 2, 1995, p. 162-165.

    Research output: Contribution to journalArticle

    Segasothy, M, Chin, GL, Sia, KK, Zulfiqar, A & Samad, SA 1995, 'Chronic nephrotoxicity of anti-inflammatory drugs used in the treatment of arthritis', British Journal of Rheumatology, vol. 34, no. 2, pp. 162-165.
    Segasothy, M. ; Chin, G. L. ; Sia, K. K. ; Zulfiqar, A. ; Samad, S. A. / Chronic nephrotoxicity of anti-inflammatory drugs used in the treatment of arthritis. In: British Journal of Rheumatology. 1995 ; Vol. 34, No. 2. pp. 162-165.
    @article{007a6104abfe4984b86836ecaf46699f,
    title = "Chronic nephrotoxicity of anti-inflammatory drugs used in the treatment of arthritis",
    abstract = "We determined the consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of chronic renal impairment and renal papillary necrosis (RPN) in patients with various types of arthritis. Ninety-four patients with chronic arthritis who had consumed more than 1000 capsules and/or tablets of NSAIDs were studied. Renal profiles and radiological investigations such as intravenous urogram (IVU), ultrasonography (US) and computed tomography (CT) were performed to look for evidence of RPN. Twelve patients did not complete the study. Ten of the 82 patients who had completed the study (12.2{\%}) had radiologic evidence of RPN. Five out of 53 patients (9.4{\%}) with rheumatoid arthritis, three out of 11 patients (27.3{\%}) with gouty arthritis and two out of seven patients (28.6{\%}) with osteoarthritis had RPN. Renal impairment (serum creatinine levels of 125-451 μmol/l) was found in 20 patients (24.4{\%}). The patients had consumed 3000-26 300 capsules and/or tablets over a period ranging from 1 yr to more than 30 yr. Patients with chronic arthritis who consume excessive amount of NSAIDs are at risk of developing RPN and chronic renal impairment.",
    keywords = "Arthritis, Chronic renal impairment, Non-steroidal anti-inflammatory drugs, Renal papillary necrosis",
    author = "M. Segasothy and Chin, {G. L.} and Sia, {K. K.} and A. Zulfiqar and Samad, {S. A.}",
    year = "1995",
    language = "English",
    volume = "34",
    pages = "162--165",
    journal = "Rheumatology",
    issn = "1462-0324",
    publisher = "Oxford University Press",
    number = "2",

    }

    TY - JOUR

    T1 - Chronic nephrotoxicity of anti-inflammatory drugs used in the treatment of arthritis

    AU - Segasothy, M.

    AU - Chin, G. L.

    AU - Sia, K. K.

    AU - Zulfiqar, A.

    AU - Samad, S. A.

    PY - 1995

    Y1 - 1995

    N2 - We determined the consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of chronic renal impairment and renal papillary necrosis (RPN) in patients with various types of arthritis. Ninety-four patients with chronic arthritis who had consumed more than 1000 capsules and/or tablets of NSAIDs were studied. Renal profiles and radiological investigations such as intravenous urogram (IVU), ultrasonography (US) and computed tomography (CT) were performed to look for evidence of RPN. Twelve patients did not complete the study. Ten of the 82 patients who had completed the study (12.2%) had radiologic evidence of RPN. Five out of 53 patients (9.4%) with rheumatoid arthritis, three out of 11 patients (27.3%) with gouty arthritis and two out of seven patients (28.6%) with osteoarthritis had RPN. Renal impairment (serum creatinine levels of 125-451 μmol/l) was found in 20 patients (24.4%). The patients had consumed 3000-26 300 capsules and/or tablets over a period ranging from 1 yr to more than 30 yr. Patients with chronic arthritis who consume excessive amount of NSAIDs are at risk of developing RPN and chronic renal impairment.

    AB - We determined the consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of chronic renal impairment and renal papillary necrosis (RPN) in patients with various types of arthritis. Ninety-four patients with chronic arthritis who had consumed more than 1000 capsules and/or tablets of NSAIDs were studied. Renal profiles and radiological investigations such as intravenous urogram (IVU), ultrasonography (US) and computed tomography (CT) were performed to look for evidence of RPN. Twelve patients did not complete the study. Ten of the 82 patients who had completed the study (12.2%) had radiologic evidence of RPN. Five out of 53 patients (9.4%) with rheumatoid arthritis, three out of 11 patients (27.3%) with gouty arthritis and two out of seven patients (28.6%) with osteoarthritis had RPN. Renal impairment (serum creatinine levels of 125-451 μmol/l) was found in 20 patients (24.4%). The patients had consumed 3000-26 300 capsules and/or tablets over a period ranging from 1 yr to more than 30 yr. Patients with chronic arthritis who consume excessive amount of NSAIDs are at risk of developing RPN and chronic renal impairment.

    KW - Arthritis

    KW - Chronic renal impairment

    KW - Non-steroidal anti-inflammatory drugs

    KW - Renal papillary necrosis

    UR - http://www.scopus.com/inward/record.url?scp=0028913116&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0028913116&partnerID=8YFLogxK

    M3 - Article

    C2 - 7704463

    AN - SCOPUS:0028913116

    VL - 34

    SP - 162

    EP - 165

    JO - Rheumatology

    JF - Rheumatology

    SN - 1462-0324

    IS - 2

    ER -