Chlorella vulgaris

A miracle plant?

Yasmin Anum Mohd Yusof, Maimunah Hassan Basri, Nor Ashikeen Mokti, Suhana Md Saad, Suhaniza Sulaiman, Nur Sajaratul Binti Yahaya, Emey Suhana Mohd Azamai, Suzana Makpol, Wan Zurinah Wan Ngah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Chlorella vulgaris (C. vulgaris), a unicellular green microalgae, has been widely used as a food supplement. It was reported to have massive amount of antioxidants such as carotenoids, vitamins E & C and enriched with several minerals. However not many studies have evaluated the chemopreventive potential of this algae against cancers. The aim of our study was to vary culture condition of C. vulgaris for best optimal growth and its hot water extract was tested for anti tumour activity by treating hepatocarcinogenesis induced rats with different doses of C. vulgaris. A plexiglas tank, measuring 1.3m in radius and 0.3m in depth, which amounts to 1000L in volume of cultured C. vulgaris was constructed. Male Wistar rats (200∼250 g) were divided into eight groups: control group (normal diet), CDE group (choline deficient diet supplemented with ethionine in drinking water to induce hepatocarcinogenesis), C. vulgaris groups with three different doses of C. vulgaris (50, 150, and 300 mg/kg body weight), and CDE groups treated with different doses of C. vulgaris (50, 150, and 300 mg/kg body weight). Rats were sacrificed at various weeks and liver tissues were embedded in paraffin blocks for immunohistochemistry studies. By varying the culture condition of C. vulgaris we found that C. vulgaris grows best with optimum yield under 24h light and 10%. In vivo studies showed that C. vulgaris reduced tumour volume with concomitant reduction in the expressions of tumour marker alfa feto protein (AFP) and anti-inflammatory marker nuclear factor kappa B (NFB) while inducing apoptosis in hepatocarcinogenesis induced rats. In conclusion, C. vulgaris extract is a miracle plant with myriads of health benefits.

Original languageEnglish
Title of host publication2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011
DOIs
Publication statusPublished - 2011
Event2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011 - Kuala Lumpur
Duration: 19 Apr 201121 Apr 2011

Other

Other2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011
CityKuala Lumpur
Period19/4/1121/4/11

Fingerprint

Chlorella
Rats
Nutrition
Tumors
Vitamins
Cell death
Algae
Antioxidants
Potable water
Liver
Paraffins
Tumor
Dose
Minerals
Health
Tissue
Proteins
Immunohistochemistry
Carotenoids
Water

Keywords

  • AFP
  • anti tumour
  • apoptosis
  • Chlorella vulgaris
  • NFκB
  • proliferation

ASJC Scopus subject areas

  • Control and Optimization
  • Modelling and Simulation

Cite this

Yusof, Y. A. M., Basri, M. H., Mokti, N. A., Saad, S. M., Sulaiman, S., Binti Yahaya, N. S., ... Wan Ngah, W. Z. (2011). Chlorella vulgaris: A miracle plant? In 2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011 [5775638] https://doi.org/10.1109/ICMSAO.2011.5775638

Chlorella vulgaris : A miracle plant? / Yusof, Yasmin Anum Mohd; Basri, Maimunah Hassan; Mokti, Nor Ashikeen; Saad, Suhana Md; Sulaiman, Suhaniza; Binti Yahaya, Nur Sajaratul; Azamai, Emey Suhana Mohd; Makpol, Suzana; Wan Ngah, Wan Zurinah.

2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011. 2011. 5775638.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yusof, YAM, Basri, MH, Mokti, NA, Saad, SM, Sulaiman, S, Binti Yahaya, NS, Azamai, ESM, Makpol, S & Wan Ngah, WZ 2011, Chlorella vulgaris: A miracle plant? in 2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011., 5775638, 2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011, Kuala Lumpur, 19/4/11. https://doi.org/10.1109/ICMSAO.2011.5775638
Yusof YAM, Basri MH, Mokti NA, Saad SM, Sulaiman S, Binti Yahaya NS et al. Chlorella vulgaris: A miracle plant? In 2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011. 2011. 5775638 https://doi.org/10.1109/ICMSAO.2011.5775638
Yusof, Yasmin Anum Mohd ; Basri, Maimunah Hassan ; Mokti, Nor Ashikeen ; Saad, Suhana Md ; Sulaiman, Suhaniza ; Binti Yahaya, Nur Sajaratul ; Azamai, Emey Suhana Mohd ; Makpol, Suzana ; Wan Ngah, Wan Zurinah. / Chlorella vulgaris : A miracle plant?. 2011 4th International Conference on Modeling, Simulation and Applied Optimization, ICMSAO 2011. 2011.
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