Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst

Farzana Shaheen, Shagufta Rasool, Zafar Ali Shah, Samreen Soomro, Almas Jabeen, Osman Mesaik Mohammed Ahmed Hassan, M. Iqbal Choudhary

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of three new secondary metabolites, 11-oxomarrubiin (1), vulgarcoside A (2) and 3-hydroxyapigenin-4′-O-(6″-O-p-coumaroyl)- β-D-glucopyranoside (3), along with four known constituents 4-7 from the polar fractions of the methanolic extract. The structures of all compounds were deduced on the basis of NMR data and HRESI-MS measurements. The new constituents 1-3 exhibited moderate to low level of inhibition on nitric oxide (NO.) production. The compound 2 also showed a moderate inhibition on pro-inflammatory cytokine TNF-α. The new constituents 1-3 showed no inhibitory effect on Reactive Oxygen Species (ROS) production.

Original languageEnglish
Pages (from-to)903-906
Number of pages4
JournalNatural Product Communications
Volume9
Issue number7
Publication statusPublished - 2014

Fingerprint

Marrubium
Marrubium vulgare
Respiratory Burst
Phytochemicals
secondary metabolites
phytopharmaceuticals
nitric oxide
reactive oxygen species
Reactive Oxygen Species
Nitric Oxide
cytokines
Cytokines
extracts

Keywords

  • Anti-inflammatory
  • Flavonoids
  • Labdane diterpene
  • Marrubium vulgare

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Complementary and alternative medicine
  • Plant Science

Cite this

Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst. / Shaheen, Farzana; Rasool, Shagufta; Shah, Zafar Ali; Soomro, Samreen; Jabeen, Almas; Mohammed Ahmed Hassan, Osman Mesaik; Choudhary, M. Iqbal.

In: Natural Product Communications, Vol. 9, No. 7, 2014, p. 903-906.

Research output: Contribution to journalArticle

Shaheen, F, Rasool, S, Shah, ZA, Soomro, S, Jabeen, A, Mohammed Ahmed Hassan, OM & Choudhary, MI 2014, 'Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst', Natural Product Communications, vol. 9, no. 7, pp. 903-906.
Shaheen, Farzana ; Rasool, Shagufta ; Shah, Zafar Ali ; Soomro, Samreen ; Jabeen, Almas ; Mohammed Ahmed Hassan, Osman Mesaik ; Choudhary, M. Iqbal. / Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst. In: Natural Product Communications. 2014 ; Vol. 9, No. 7. pp. 903-906.
@article{2bdafb76e49a4c999f1cd5dabdcb85ce,
title = "Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst",
abstract = "Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of three new secondary metabolites, 11-oxomarrubiin (1), vulgarcoside A (2) and 3-hydroxyapigenin-4′-O-(6″-O-p-coumaroyl)- β-D-glucopyranoside (3), along with four known constituents 4-7 from the polar fractions of the methanolic extract. The structures of all compounds were deduced on the basis of NMR data and HRESI-MS measurements. The new constituents 1-3 exhibited moderate to low level of inhibition on nitric oxide (NO.) production. The compound 2 also showed a moderate inhibition on pro-inflammatory cytokine TNF-α. The new constituents 1-3 showed no inhibitory effect on Reactive Oxygen Species (ROS) production.",
keywords = "Anti-inflammatory, Flavonoids, Labdane diterpene, Marrubium vulgare",
author = "Farzana Shaheen and Shagufta Rasool and Shah, {Zafar Ali} and Samreen Soomro and Almas Jabeen and {Mohammed Ahmed Hassan}, {Osman Mesaik} and Choudhary, {M. Iqbal}",
year = "2014",
language = "English",
volume = "9",
pages = "903--906",
journal = "Natural Product Communications",
issn = "1934-578X",
publisher = "Natural Product Communications",
number = "7",

}

TY - JOUR

T1 - Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst

AU - Shaheen, Farzana

AU - Rasool, Shagufta

AU - Shah, Zafar Ali

AU - Soomro, Samreen

AU - Jabeen, Almas

AU - Mohammed Ahmed Hassan, Osman Mesaik

AU - Choudhary, M. Iqbal

PY - 2014

Y1 - 2014

N2 - Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of three new secondary metabolites, 11-oxomarrubiin (1), vulgarcoside A (2) and 3-hydroxyapigenin-4′-O-(6″-O-p-coumaroyl)- β-D-glucopyranoside (3), along with four known constituents 4-7 from the polar fractions of the methanolic extract. The structures of all compounds were deduced on the basis of NMR data and HRESI-MS measurements. The new constituents 1-3 exhibited moderate to low level of inhibition on nitric oxide (NO.) production. The compound 2 also showed a moderate inhibition on pro-inflammatory cytokine TNF-α. The new constituents 1-3 showed no inhibitory effect on Reactive Oxygen Species (ROS) production.

AB - Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of three new secondary metabolites, 11-oxomarrubiin (1), vulgarcoside A (2) and 3-hydroxyapigenin-4′-O-(6″-O-p-coumaroyl)- β-D-glucopyranoside (3), along with four known constituents 4-7 from the polar fractions of the methanolic extract. The structures of all compounds were deduced on the basis of NMR data and HRESI-MS measurements. The new constituents 1-3 exhibited moderate to low level of inhibition on nitric oxide (NO.) production. The compound 2 also showed a moderate inhibition on pro-inflammatory cytokine TNF-α. The new constituents 1-3 showed no inhibitory effect on Reactive Oxygen Species (ROS) production.

KW - Anti-inflammatory

KW - Flavonoids

KW - Labdane diterpene

KW - Marrubium vulgare

UR - http://www.scopus.com/inward/record.url?scp=84905103683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905103683&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 903

EP - 906

JO - Natural Product Communications

JF - Natural Product Communications

SN - 1934-578X

IS - 7

ER -