Chemical constituents of euphorbia polyacantha Boiss. and their immunomodulatory properties

Gihan O M ELhassan, Achyut Adhikari, Omer M. Abdalla, Ahmed Shukrulla, Asaad Khalid, M. Iqbal Choudhary, Osman Mesaik Mohammed Ahmed Hassan, Sakina Yagi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Phytochemical investigation on the stem of Euphorbia polyacantha Boiss. (Euphorbiaceae) afforded a new anthraquinone named as 1, 8-dihydroxy -3- (hydroxyl methyl) -5- methoxy anthracene- 9,10- dione (1) along with three known compounds, aloe emodin (2), 3, 4, 3′–tri-O-methyl ellagic acid (3), and 3,3′,4, 4′- tetra- O-methyl ellagic acid (4). Their structures were determined on the basis of IR, 1D- and 2D- NMR spectroscopy and mass spectrometry analysis. The effect of isolated compounds on oxidative burst of neutrophils and T-cell proliferation response was studied. Compounds 3 and 1 displayed strong oxidative burst inhibitory activity with IC502 ± 0 and 3.5 ± 1.1 μg/mL respectively, whereas they moderately inhibited the T-cell proliferation with IC5028.5 ± 1.8 and 22.5 ± 2.0 μg/mL respectively. Compound 2 was relatively inactive with IC5043.2 μg/mL in oxidative burst and >50 μg/mL in case of T-cell proliferation. This is the first report on the phytochemical profile and biological activity of E. polyacantha.

Original languageEnglish
Pages (from-to)146-152
Number of pages7
JournalRecords of Natural Products
Volume9
Issue number1
Publication statusPublished - 2015

Fingerprint

Euphorbia
Respiratory Burst
T-cells
Cell proliferation
Ellagic Acid
cell proliferation
ellagic acid
T-lymphocytes
Cell Proliferation
Phytochemicals
T-Lymphocytes
phytopharmaceuticals
Euphorbiaceae
emodin
Aloe
Anthraquinones
anthraquinones
Bioactivity
Hydroxyl Radical
Nuclear magnetic resonance spectroscopy

Keywords

  • Anthraquinone
  • Euphorbia polyacantha
  • Immunomodulation
  • Oxidative burst
  • T-cell proliferation

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology
  • Plant Science

Cite this

ELhassan, G. O. M., Adhikari, A., Abdalla, O. M., Shukrulla, A., Khalid, A., Iqbal Choudhary, M., ... Yagi, S. (2015). Chemical constituents of euphorbia polyacantha Boiss. and their immunomodulatory properties. Records of Natural Products, 9(1), 146-152.

Chemical constituents of euphorbia polyacantha Boiss. and their immunomodulatory properties. / ELhassan, Gihan O M; Adhikari, Achyut; Abdalla, Omer M.; Shukrulla, Ahmed; Khalid, Asaad; Iqbal Choudhary, M.; Mohammed Ahmed Hassan, Osman Mesaik; Yagi, Sakina.

In: Records of Natural Products, Vol. 9, No. 1, 2015, p. 146-152.

Research output: Contribution to journalArticle

ELhassan, GOM, Adhikari, A, Abdalla, OM, Shukrulla, A, Khalid, A, Iqbal Choudhary, M, Mohammed Ahmed Hassan, OM & Yagi, S 2015, 'Chemical constituents of euphorbia polyacantha Boiss. and their immunomodulatory properties', Records of Natural Products, vol. 9, no. 1, pp. 146-152.
ELhassan GOM, Adhikari A, Abdalla OM, Shukrulla A, Khalid A, Iqbal Choudhary M et al. Chemical constituents of euphorbia polyacantha Boiss. and their immunomodulatory properties. Records of Natural Products. 2015;9(1):146-152.
ELhassan, Gihan O M ; Adhikari, Achyut ; Abdalla, Omer M. ; Shukrulla, Ahmed ; Khalid, Asaad ; Iqbal Choudhary, M. ; Mohammed Ahmed Hassan, Osman Mesaik ; Yagi, Sakina. / Chemical constituents of euphorbia polyacantha Boiss. and their immunomodulatory properties. In: Records of Natural Products. 2015 ; Vol. 9, No. 1. pp. 146-152.
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