Chemical components and bioactivity of the marine-derived fungus Paecilomyces sp. Collected from Tinggi Island, Malaysia

Z. Mosadeghzad, Z. Zuriati, Asmat Ahmad, Gires Usup, R Wickneswari V Ratnam, P. Pittayakhajonwut, G. H N Farahani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The marine fungus Paecilomyces sp., derived from the marine sponge collected along Tinggi Island, Malaysia, was cultivated and incubated for 7 days at 30 C. The liquid cultures were then extracted, and the crude extract was investigated for its antimicrobial activity. Purification of the crude extract resulted in the isolation of the new (3R*,5E,7E,9R*,11E,13Z)-1- ((3′aS*,6′aR*)-2′-amino-5′-oxo-3′a, 5′,6′,6′a-tetrahydrofuro [3′,2′-b]furan-3-yl)-3,7, 9,11-tetramethylheptadeca-5,7,11,13-tetraene-1,2-dione (1) and four known metabolites, stigmasterol (2), cholesteryl linoleate (3), linoleic acid (4), and 2,5-furandimethanol (5). The structures of the components were elucidated by spectroscopic methods. The antimicrobial activities of all the isolated compounds were evaluated against a panel of bacteria and fungi.

Original languageEnglish
Pages (from-to)621-625
Number of pages5
JournalChemistry of Natural Compounds
Volume49
Issue number4
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Paecilomyces
Malaysia
anti-infective agents
marine fungi
fungi
stigmasterol
furans
extracts
Porifera
linoleic acid
metabolites
liquids
bacteria
methodology

Keywords

  • antimicrobial activity
  • marine fungi
  • MRSA
  • Paecilomyces

ASJC Scopus subject areas

  • Plant Science

Cite this

Chemical components and bioactivity of the marine-derived fungus Paecilomyces sp. Collected from Tinggi Island, Malaysia. / Mosadeghzad, Z.; Zuriati, Z.; Ahmad, Asmat; Usup, Gires; V Ratnam, R Wickneswari; Pittayakhajonwut, P.; Farahani, G. H N.

In: Chemistry of Natural Compounds, Vol. 49, No. 4, 09.2013, p. 621-625.

Research output: Contribution to journalArticle

Mosadeghzad, Z. ; Zuriati, Z. ; Ahmad, Asmat ; Usup, Gires ; V Ratnam, R Wickneswari ; Pittayakhajonwut, P. ; Farahani, G. H N. / Chemical components and bioactivity of the marine-derived fungus Paecilomyces sp. Collected from Tinggi Island, Malaysia. In: Chemistry of Natural Compounds. 2013 ; Vol. 49, No. 4. pp. 621-625.
@article{0c2e41877135413b9da8cf4209f5b4b6,
title = "Chemical components and bioactivity of the marine-derived fungus Paecilomyces sp. Collected from Tinggi Island, Malaysia",
abstract = "The marine fungus Paecilomyces sp., derived from the marine sponge collected along Tinggi Island, Malaysia, was cultivated and incubated for 7 days at 30 C. The liquid cultures were then extracted, and the crude extract was investigated for its antimicrobial activity. Purification of the crude extract resulted in the isolation of the new (3R*,5E,7E,9R*,11E,13Z)-1- ((3′aS*,6′aR*)-2′-amino-5′-oxo-3′a, 5′,6′,6′a-tetrahydrofuro [3′,2′-b]furan-3-yl)-3,7, 9,11-tetramethylheptadeca-5,7,11,13-tetraene-1,2-dione (1) and four known metabolites, stigmasterol (2), cholesteryl linoleate (3), linoleic acid (4), and 2,5-furandimethanol (5). The structures of the components were elucidated by spectroscopic methods. The antimicrobial activities of all the isolated compounds were evaluated against a panel of bacteria and fungi.",
keywords = "antimicrobial activity, marine fungi, MRSA, Paecilomyces",
author = "Z. Mosadeghzad and Z. Zuriati and Asmat Ahmad and Gires Usup and {V Ratnam}, {R Wickneswari} and P. Pittayakhajonwut and Farahani, {G. H N}",
year = "2013",
month = "9",
doi = "10.1007/s10600-013-0693-y",
language = "English",
volume = "49",
pages = "621--625",
journal = "Chemistry of Natural Compounds",
issn = "0009-3130",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Chemical components and bioactivity of the marine-derived fungus Paecilomyces sp. Collected from Tinggi Island, Malaysia

AU - Mosadeghzad, Z.

AU - Zuriati, Z.

AU - Ahmad, Asmat

AU - Usup, Gires

AU - V Ratnam, R Wickneswari

AU - Pittayakhajonwut, P.

AU - Farahani, G. H N

PY - 2013/9

Y1 - 2013/9

N2 - The marine fungus Paecilomyces sp., derived from the marine sponge collected along Tinggi Island, Malaysia, was cultivated and incubated for 7 days at 30 C. The liquid cultures were then extracted, and the crude extract was investigated for its antimicrobial activity. Purification of the crude extract resulted in the isolation of the new (3R*,5E,7E,9R*,11E,13Z)-1- ((3′aS*,6′aR*)-2′-amino-5′-oxo-3′a, 5′,6′,6′a-tetrahydrofuro [3′,2′-b]furan-3-yl)-3,7, 9,11-tetramethylheptadeca-5,7,11,13-tetraene-1,2-dione (1) and four known metabolites, stigmasterol (2), cholesteryl linoleate (3), linoleic acid (4), and 2,5-furandimethanol (5). The structures of the components were elucidated by spectroscopic methods. The antimicrobial activities of all the isolated compounds were evaluated against a panel of bacteria and fungi.

AB - The marine fungus Paecilomyces sp., derived from the marine sponge collected along Tinggi Island, Malaysia, was cultivated and incubated for 7 days at 30 C. The liquid cultures were then extracted, and the crude extract was investigated for its antimicrobial activity. Purification of the crude extract resulted in the isolation of the new (3R*,5E,7E,9R*,11E,13Z)-1- ((3′aS*,6′aR*)-2′-amino-5′-oxo-3′a, 5′,6′,6′a-tetrahydrofuro [3′,2′-b]furan-3-yl)-3,7, 9,11-tetramethylheptadeca-5,7,11,13-tetraene-1,2-dione (1) and four known metabolites, stigmasterol (2), cholesteryl linoleate (3), linoleic acid (4), and 2,5-furandimethanol (5). The structures of the components were elucidated by spectroscopic methods. The antimicrobial activities of all the isolated compounds were evaluated against a panel of bacteria and fungi.

KW - antimicrobial activity

KW - marine fungi

KW - MRSA

KW - Paecilomyces

UR - http://www.scopus.com/inward/record.url?scp=84885840135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885840135&partnerID=8YFLogxK

U2 - 10.1007/s10600-013-0693-y

DO - 10.1007/s10600-013-0693-y

M3 - Article

VL - 49

SP - 621

EP - 625

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

SN - 0009-3130

IS - 4

ER -