Pencirian dan kajian antimikrobial terhadap lima sebatian bis-tiourea

Translated title of the contribution: Characterization and antimicrobial studies of five substituted bis-thioureas

Nurulain Kamalulazmy, Sahilah Abd. Mutalib, Fatin Ilyani Nasir, Nurul Izzaty Hassan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Thioureas play an important role in medicinal chemistry and agricultures due to their biological activity such as antibacterial, antifungal, antiviral, herbicides, rodenticides,phenoloxidase enzymatic inhibitors, anti-HIV and anti-tumor agents. In this study, five substituted bis-thioureas have been synthesized. The isophataloyl chloride and 2,6-pyridinedicarbonyl dichloride were easily converted to bis-isothiocyanate compound via the reaction with ammonium thiocyanate by solid–liquid phase transfer catalysis ofpolyethylene glycol-400 (PEG-400). Bis-isothiocyanate compound was reacted with aniline derivatives to produce substituted bis-thioureas in good yield at room temperature. All thenovel compounds were obtained as yellow solid after recrystallization using DMF/EtOH/H2O. Their chemical structures were confirmed by Infrared spectrosopy (IR), NuclearMagnetic Resonance (NMR) 1H and 13C and mass spectrometry. The five synthesized compounds were screened for antimicrobial activities using disc diffusion method forantimicrobial activity against Gram-positive bacteria (Bacillus Subtilis and Staphylococcus Aureus), Gram-negative bacteria (Escherichia Coli and Salmonella Typhi) and a mold(Aspergillus Niger). All tested compounds showed low antimicrobial activity since the diameter of inhibition zone (IZ) measure was less than positive control inhibition zone.

Original languageMalay
Pages (from-to)85-90
Number of pages6
JournalMalaysian Journal of Analytical Sciences
Volume20
Issue number1
Publication statusPublished - 2016

Fingerprint

Thiourea
Bacteria
Rodenticides
Salmonella
Glycols
Monophenol Monooxygenase
Aspergillus
Herbicides
Bacilli
Bioactivity
Agriculture
Escherichia coli
Catalysis
Antiviral Agents
Mass spectrometry
Chlorides
Tumors
Infrared radiation
Derivatives
Temperature

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Pencirian dan kajian antimikrobial terhadap lima sebatian bis-tiourea. / Kamalulazmy, Nurulain; Abd. Mutalib, Sahilah; Nasir, Fatin Ilyani; Hassan, Nurul Izzaty.

In: Malaysian Journal of Analytical Sciences, Vol. 20, No. 1, 2016, p. 85-90.

Research output: Contribution to journalArticle

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