Characteristics of community- and hospital-acquired meticillin-resistant Staphylococcus aureus strains carrying SCCmec type IV isolated in Malaysia

Norazah Ahmad, Izayu Nurfarha Ruzan, Mohamed Kamel Abdul Ghani, Azura Hussin, Salbiah Nawi, Mohamad Nazri Aziz, Nurahan Maning, Victor Lim Kok Eow

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) occurring among hospital isolates in Malaysia has not been reported previously. As CA-MRSA reported worldwide has been shown to carry SCCmec types IV and V, the aim of this study was to determine the SCCmec types of MRSA strains collected in Malaysia from November 2006 to June 2008. From a total of 628 MRSA isolates, 20 were SCCmec type IV, whilst the rest were type III. Further characterization of SCCmec type IV strains revealed 11 sequence types (STs), including ST22, with the majority being ST30/Panton-Valentine leukocidin positive. Eight out of nine CA-MRSA were ST30, one was ST80, and all were sensitive to co-trimoxazole and gentamicin. Five new STs designated ST1284, ST1285, ST1286, ST1287 and ST1288 were discovered, suggesting the emergence of novel clones of MRSA circulating in Malaysian hospitals. The discovery of the ST22 strain is a cause for concern because of its ability to replace existing predominant clones in certain geographical regions.

Original languageEnglish
Pages (from-to)1213-1218
Number of pages6
JournalJournal of Medical Microbiology
Volume58
Issue number9
DOIs
Publication statusPublished - Sep 2009

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Methicillin
Malaysia
Community Hospital
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Clone Cells
Sulfamethoxazole Drug Combination Trimethoprim
Gentamicins
homocysteine-thiolactone-nicotinamide

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Characteristics of community- and hospital-acquired meticillin-resistant Staphylococcus aureus strains carrying SCCmec type IV isolated in Malaysia. / Ahmad, Norazah; Ruzan, Izayu Nurfarha; Abdul Ghani, Mohamed Kamel; Hussin, Azura; Nawi, Salbiah; Aziz, Mohamad Nazri; Maning, Nurahan; Eow, Victor Lim Kok.

In: Journal of Medical Microbiology, Vol. 58, No. 9, 09.2009, p. 1213-1218.

Research output: Contribution to journalArticle

Ahmad, Norazah ; Ruzan, Izayu Nurfarha ; Abdul Ghani, Mohamed Kamel ; Hussin, Azura ; Nawi, Salbiah ; Aziz, Mohamad Nazri ; Maning, Nurahan ; Eow, Victor Lim Kok. / Characteristics of community- and hospital-acquired meticillin-resistant Staphylococcus aureus strains carrying SCCmec type IV isolated in Malaysia. In: Journal of Medical Microbiology. 2009 ; Vol. 58, No. 9. pp. 1213-1218.
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