Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro

Noraini Nordin, Samikannu Kanagesan, Nur Rizi Zamberi, Swee Keong Yeap, Nadiah Abu, Subramani Tamilselvan, Mansor Hashim, Noorjahan Banu Alitheen

Research output: Contribution to journalArticle

Abstract

In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol-gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform infrared spectroscopy and X-ray diffraction. Transmission electron microscopy revealed that the average particle size of the calcined sample was in a range of 17-41 nm with an average of 29 nm and has spherical size. A cytotoxicity test was performed on human breast cancer cells (MDA MB-231) and (MCF-7) at various concentrations starting from (0 μg/ml) to (800 μg/ml). The sample possessed a mild toxic effect toward MDA MB-231 and MCF-7 after being examined with MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay for up to 72 h of incubation. Higher reduction of cells viability was observed as the concentration of sample was increased in MDA MB-231 cell line than in MCF-7. Therefore, further cytotoxicity tests were performed on MDA MB-231 cell line.

Original languageEnglish
Pages (from-to)343-348
Number of pages6
JournalIET Nanobiotechnology
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

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Polymethyl Methacrylate
Nanoparticles
Sol-gel process
Gels
Differential Thermal Analysis
Cells
Breast Neoplasms
Cell Line
Poisons
Fourier Transform Infrared Spectroscopy
Cytotoxicity
Transmission Electron Microscopy
Particle Size
X-Ray Diffraction
Nitrates
Zinc
Copper
Cell Survival
Differential thermal analysis
Magnesium

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biotechnology
  • Electrical and Electronic Engineering

Cite this

Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro. / Nordin, Noraini; Kanagesan, Samikannu; Zamberi, Nur Rizi; Yeap, Swee Keong; Abu, Nadiah; Tamilselvan, Subramani; Hashim, Mansor; Alitheen, Noorjahan Banu.

In: IET Nanobiotechnology, Vol. 11, No. 3, 01.01.2017, p. 343-348.

Research output: Contribution to journalArticle

Nordin, Noraini ; Kanagesan, Samikannu ; Zamberi, Nur Rizi ; Yeap, Swee Keong ; Abu, Nadiah ; Tamilselvan, Subramani ; Hashim, Mansor ; Alitheen, Noorjahan Banu. / Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro. In: IET Nanobiotechnology. 2017 ; Vol. 11, No. 3. pp. 343-348.
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