Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels

Abhishek Gupta, Wan Li Low, Iza Radecka, Stephen T. Britland, Mohd Cairul Iqbal Mohd Amin, Claire Martin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Wounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S. aureus and P. aeruginosa. Silver nitrate and silver zeolite provided the source of silver and loading parameters were optimised based on experimental findings. The results indicate that both AgNO3 and AgZ loaded biosynthetic hydrogels possess antimicrobial activity (p <.05) against both S. aureus and P. aeruginosa and may therefore be suitable for wound management applications.

Original languageEnglish
Pages (from-to)725-734
Number of pages10
JournalJournal of Microencapsulation
Volume33
Issue number8
DOIs
Publication statusPublished - 16 Nov 2016

Fingerprint

Hydrogels
cellulose
Silver
Cellulose
silver
Wounds and Injuries
wound healing
Zeolites
Silver Nitrate
silver nitrates
pathogens
Pathogens
infectious diseases
microorganisms
Gluconacetobacter xylinus
Microorganisms
Re-Epithelialization
Nitrates
Bandages
Wound Healing

Keywords

  • Antimicrobial
  • bacterial cellulose
  • hydrogel
  • silver
  • silver zeolite

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels. / Gupta, Abhishek; Low, Wan Li; Radecka, Iza; Britland, Stephen T.; Mohd Amin, Mohd Cairul Iqbal; Martin, Claire.

In: Journal of Microencapsulation, Vol. 33, No. 8, 16.11.2016, p. 725-734.

Research output: Contribution to journalArticle

Gupta, Abhishek ; Low, Wan Li ; Radecka, Iza ; Britland, Stephen T. ; Mohd Amin, Mohd Cairul Iqbal ; Martin, Claire. / Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels. In: Journal of Microencapsulation. 2016 ; Vol. 33, No. 8. pp. 725-734.
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