Challenges and future direction of molecular research in air pollution-related lung cancers

Maizatul Syafinaz Shahadin, Nurul Syakima Ab Mutalib, Mohd Talib Latif, Catherine M. Greene, Hassan Tidi Maharani

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Hazardous air pollutants or chemical release into the environment by a variety of natural and/or anthropogenic activities may give adverse effects to human health. Air pollutants such as sulphur dioxide (SO2), nitrogen oxides (NOx), carbon monoxide (CO), heavy metals and particulate matter (PM) affect number of different human organs, especially the respiratory system. The International Agency for Research on Cancer (IARC) reported that ambient air pollution is a cause of lung cancer. Recently, the agency has classified outdoor air pollution as well as PM air pollution as Group 1 carcinogens. In addition, several epidemiological studies have shown a positive association between air pollutants to lung cancer risks and mortality. However, there are only a few studies examining the molecular effects of air pollution exposure specifically in lung cancer due to multiple challenges to mimic air pollution exposure in basic experimentation. Another major issue is the lack of adequate adjustments for exposure misclassification as air pollution may differ temporo-spatially and socioeconomically. Thus, the purpose of this paper is to review the current molecular understanding of air pollution-related lung cancer and potential future direction in this challenging yet important research field.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalLung Cancer
Volume118
DOIs
Publication statusPublished - 1 Apr 2018

Fingerprint

Air Pollution
Lung Neoplasms
Air Pollutants
Research
Particulate Matter
Nitrogen Oxides
International Agencies
Sulfur Dioxide
Carbon Monoxide
Heavy Metals
Direction compound
Respiratory System
Carcinogens
Epidemiologic Studies
Mortality
Health
Neoplasms

Keywords

  • Air pollution
  • Biomarkers
  • Challenge
  • Lung cancer
  • Molecular mechanism

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Challenges and future direction of molecular research in air pollution-related lung cancers. / Shahadin, Maizatul Syafinaz; Ab Mutalib, Nurul Syakima; Latif, Mohd Talib; Greene, Catherine M.; Tidi Maharani, Hassan.

In: Lung Cancer, Vol. 118, 01.04.2018, p. 69-75.

Research output: Contribution to journalReview article

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