Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb

Ozlem Demirkiran, Osman Mesaik Mohammed Ahmed Hassan, Hayrettin Beynek, Ahmed Abbaskhan, M. Iqbal Choudhary

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The phytochemical investigation of the ethyl acetate extract of Hypericum thasium has led to the characterization of four benzophenone derivatives 1-4, a known benzophenone 5 and four known flavonoids, quercetin (6), quercitrin (7), isoquercetin (8), and 3, 8′′-biapigenin (9). Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds towards the production of reactive oxygen species (ROS) by human polymorphoneutrophils (PMNs). The assay results showed that benzophenones 1 and 3 are extracellular inhibitors of ROS production, while flavonoids 6, 8, and 9 can modulate intracellular ROS production.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalPhytochemistry
Volume70
Issue number2
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Fingerprint

benzophenone
Hypericum
reactive oxygen species
Reactive Oxygen Species
Flavonoids
Assays
Benzophenones
flavonoids
quercitrin
Chemiluminescence
chemiluminescence
Quercetin
Phytochemicals
assays
Luminescence
quercetin
phytopharmaceuticals
chemical derivatives
Derivatives
extracts

Keywords

  • Benzophenone glycosides
  • Guttiferae
  • Hypericum thasium
  • Inhibition of ROS
  • Reactive oxygen species (ROS)

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Horticulture

Cite this

Demirkiran, O., Mohammed Ahmed Hassan, O. M., Beynek, H., Abbaskhan, A., & Iqbal Choudhary, M. (2009). Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb. Phytochemistry, 70(2), 244-249. https://doi.org/10.1016/j.phytochem.2008.10.006

Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb. / Demirkiran, Ozlem; Mohammed Ahmed Hassan, Osman Mesaik; Beynek, Hayrettin; Abbaskhan, Ahmed; Iqbal Choudhary, M.

In: Phytochemistry, Vol. 70, No. 2, 01.2009, p. 244-249.

Research output: Contribution to journalArticle

Demirkiran, O, Mohammed Ahmed Hassan, OM, Beynek, H, Abbaskhan, A & Iqbal Choudhary, M 2009, 'Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb', Phytochemistry, vol. 70, no. 2, pp. 244-249. https://doi.org/10.1016/j.phytochem.2008.10.006
Demirkiran O, Mohammed Ahmed Hassan OM, Beynek H, Abbaskhan A, Iqbal Choudhary M. Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb. Phytochemistry. 2009 Jan;70(2):244-249. https://doi.org/10.1016/j.phytochem.2008.10.006
Demirkiran, Ozlem ; Mohammed Ahmed Hassan, Osman Mesaik ; Beynek, Hayrettin ; Abbaskhan, Ahmed ; Iqbal Choudhary, M. / Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb. In: Phytochemistry. 2009 ; Vol. 70, No. 2. pp. 244-249.
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