Cellular model of electroporated tissue for ultrasound RF data analysis

Ali Dashti, Edmond Zahedi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electroporation is permeabilization of the cell membrane, caused by an external electric field. Because of minimal thermal effects and minimal disturbance caused to tissue vasculature electroporation is becoming one of the methods of choice in tumor therapy. There has been no report indicating that reversible electroporation can be detected by ultrasound. In this work a cellular model for monitoring the electroporation process b; ultrasound RF signals is proposed. The density of aqueous pores with different sizes was found by applying the asymptotic model of electroporation and Smoluchowski equation. The cellular model was send to an ultrasound simulation program where pores were modeled by reducing the number of reflective mechanical scatterers in cell's membrane. Results are expected to be used as an indication of electroporation's effect on cells allowing for the real-time monitoring of this process. Ultimately, an experimental verification would then allow the validation and refinement of the model

Original languageEnglish
Title of host publication2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009
Pages652-655
Number of pages4
DOIs
Publication statusPublished - 2009
Externally publishedYes
Event2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009 - Beirut
Duration: 15 Jul 200917 Jul 2009

Other

Other2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009
CityBeirut
Period15/7/0917/7/09

Fingerprint

Ultrasonics
Tissue
Cell membranes
Monitoring
Thermal effects
Tumors
Electric fields

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Control and Systems Engineering
  • Electrical and Electronic Engineering

Cite this

Dashti, A., & Zahedi, E. (2009). Cellular model of electroporated tissue for ultrasound RF data analysis. In 2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009 (pp. 652-655). [5227915] https://doi.org/10.1109/ACTEA.2009.5227915

Cellular model of electroporated tissue for ultrasound RF data analysis. / Dashti, Ali; Zahedi, Edmond.

2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009. 2009. p. 652-655 5227915.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dashti, A & Zahedi, E 2009, Cellular model of electroporated tissue for ultrasound RF data analysis. in 2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009., 5227915, pp. 652-655, 2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009, Beirut, 15/7/09. https://doi.org/10.1109/ACTEA.2009.5227915
Dashti A, Zahedi E. Cellular model of electroporated tissue for ultrasound RF data analysis. In 2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009. 2009. p. 652-655. 5227915 https://doi.org/10.1109/ACTEA.2009.5227915
Dashti, Ali ; Zahedi, Edmond. / Cellular model of electroporated tissue for ultrasound RF data analysis. 2009 International Conference on Advances in Computational Tools for Engineering Applications, ACTEA 2009. 2009. pp. 652-655
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