Cellular and physiological soft tissue response in hip arthroplasty and its management

Shahril R. Shaarani, Hassan Tidi Maharani, Ann Igoe, Gavin McHugh, Denis Collins

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Metallic and non-metallic orthopaedic prostheses have been used widely to replace painful, stiff and mechanically disadvantaged hips. Though the biomaterials used in these implants have been generally considered as inert, adverse tissue reactions in metal-on-polyethylene and more recently metal-on-metal hip arthroplasties have been described since the early 1970s. This can result in premature failure of these implants and need for revision surgery. Recently, a specific implant has been recalled inter-nationally. There has been a worldwide increase in the rate of revision surgery for hip resurfacing arthroplasty due to adverse soft tissue reactions. Inflammatory pseudotumours are a well-described clinical complication of metal-on-metal and recent evidence has suggested similar complications for non-metal-on-metal hip implants. Metal hypersensitivity has been characterized by a predominantly lymphocytic immune response and causes soft-tissue changes such as effusions, pseudotumours and osteolysis. Radiological and histopathological studies have characterized this phenomenon with inflammation, with an emphasis on metal debris as integral to the pathogenesis of this phenomenon. Also, the carcinogenic properties of cadmium, chromium, cobalt, beryllium and other metals utilized in orthopaedic devices have been proven in animal models. This book chapter will discuss the biologic and physical effects of hip athroplasty on soft tissue including pseudotumours and hip arthroplasty-related malignancies.

Original languageEnglish
Title of host publicationSoft Tissue: Composition, Mechanisms of Injury and Repair
PublisherNova Science Publishers, Inc.
Pages35-66
Number of pages32
ISBN (Print)9781622573639
Publication statusPublished - Sep 2012
Externally publishedYes

Fingerprint

Arthroplasty
Hip
Metals
Reoperation
Orthopedics
Plasma Cell Granuloma
Beryllium
Osteolysis
Biocompatible Materials
Polyethylene
Vulnerable Populations
Chromium
Cobalt
Cadmium
Prostheses and Implants
Hypersensitivity
Animal Models
Inflammation
Equipment and Supplies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Shaarani, S. R., Tidi Maharani, H., Igoe, A., McHugh, G., & Collins, D. (2012). Cellular and physiological soft tissue response in hip arthroplasty and its management. In Soft Tissue: Composition, Mechanisms of Injury and Repair (pp. 35-66). Nova Science Publishers, Inc..

Cellular and physiological soft tissue response in hip arthroplasty and its management. / Shaarani, Shahril R.; Tidi Maharani, Hassan; Igoe, Ann; McHugh, Gavin; Collins, Denis.

Soft Tissue: Composition, Mechanisms of Injury and Repair. Nova Science Publishers, Inc., 2012. p. 35-66.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shaarani, SR, Tidi Maharani, H, Igoe, A, McHugh, G & Collins, D 2012, Cellular and physiological soft tissue response in hip arthroplasty and its management. in Soft Tissue: Composition, Mechanisms of Injury and Repair. Nova Science Publishers, Inc., pp. 35-66.
Shaarani SR, Tidi Maharani H, Igoe A, McHugh G, Collins D. Cellular and physiological soft tissue response in hip arthroplasty and its management. In Soft Tissue: Composition, Mechanisms of Injury and Repair. Nova Science Publishers, Inc. 2012. p. 35-66
Shaarani, Shahril R. ; Tidi Maharani, Hassan ; Igoe, Ann ; McHugh, Gavin ; Collins, Denis. / Cellular and physiological soft tissue response in hip arthroplasty and its management. Soft Tissue: Composition, Mechanisms of Injury and Repair. Nova Science Publishers, Inc., 2012. pp. 35-66
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