Cellular and molecular changes in orthodontic tooth movement

Shahrul Hisham Zainal Ariffin, Zulham Yamamoto, Lntan Zarina Zainol Abidin, Rohaya Megat Abdul Wahab, Zaidah Zainal Ariffin

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Tooth movement induced by orthodontic treatment can cause sequential reactions involving the periodontal tissue and alveolar bone, resulting in the release of numerous substances from the dental tissues and surrounding structures. To better understand the biological processes involved in orthodontic treatment, improve treatment, and reduce adverse side effects, several of these substances have been proposed as biomarkers. Potential biological markers can be collected from different tissue samples, and suitable sampling is important to accurately reflect biological processes. This paper covers the tissue changes that are involved during orthodontic tooth movement such as at compression region (involving osteoblasts), tension region (involving osteoclasts), dental root, and pulp tissues. Besides, the involvement of stem cells and their development towards osteoblasts and osteoclasts during orthodontic treatment have also been explained. Several possible biomarkers representing these biological changes during specific phenomenon, that is, bone remodelling (formation and resorption), inflammation, and root resorption have also been proposed. The knowledge of these biomarkers could be used in accelerating orthodontic treatment.

Original languageEnglish
Pages (from-to)1788-1803
Number of pages16
JournalTheScientificWorldJournal
Volume11
DOIs
Publication statusPublished - 2011

Fingerprint

Tooth Movement Techniques
tooth
Orthodontics
Biomarkers
Tissue
Biological Phenomena
Osteoclasts
biomarker
Osteoblasts
resorption
biological processes
bone
Root Resorption
Tooth Root
Bone
Dental Pulp
Bone Remodeling
Bone Resorption
Osteogenesis
Tooth

Keywords

  • biomarker
  • bone remodelling
  • inflammation
  • Orthodontic
  • root resorption
  • stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Cellular and molecular changes in orthodontic tooth movement. / Zainal Ariffin, Shahrul Hisham; Yamamoto, Zulham; Zainol Abidin, Lntan Zarina; Megat Abdul Wahab, Rohaya; Zainal Ariffin, Zaidah.

In: TheScientificWorldJournal, Vol. 11, 2011, p. 1788-1803.

Research output: Contribution to journalArticle

Zainal Ariffin, Shahrul Hisham ; Yamamoto, Zulham ; Zainol Abidin, Lntan Zarina ; Megat Abdul Wahab, Rohaya ; Zainal Ariffin, Zaidah. / Cellular and molecular changes in orthodontic tooth movement. In: TheScientificWorldJournal. 2011 ; Vol. 11. pp. 1788-1803.
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