Case series of cultivated oral mucosa epithelium transplantation for limbal stem cell failure: Experience in Malaysia

Kah Lay Oh, Aida Zairani Mohd Zahidin, Umi Kalthum Md Noh, Safinaz Mohd Khialdin, Ghee Chien Ooi, Kong Yong Then

Research output: Contribution to journalArticle

Abstract

Purpose: To report a case series of seven eyes (six patients) with severe limbal stem cell failure who underwent cultivated oral mucosa epithelium transplantation (COMET) in preparation for corneal transplant surgery and assess the change in visual acuity postoperatively. Design: Case series. Methods: A retrospective analysis of an interventional case series of six patients with severe limbal stem cell deficiency who underwent COMET between 2012 and 2015 was performed. Six eyes had COMET followed by corneal transplant, and one eye had corneal transplant preceding COMET. The change in the visual acuity after operation was evaluated. Results: A total of six patients with seven eyes were studied. All of them had severe ocular surface disease with limbal stem cell deficiency (LSCD) secondary to chemical injury (five eyes), SJS (one eye), and severe ocular rosacea (one eye). Four eyes had improvements in visual acuity, two of which achieved best corrected visual acuity (BCVA) of 6/12. Conclusion: The use of COMET helps to optimize the ocular surface in severe LSCD for further corneal transplant surgeries. It has helped to improve the graft uptake and subsequent visual improvement, especially in chronic chemical burn cases.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalAsian Journal of Ophthalmology
Volume16
Issue number2
Publication statusPublished - 1 Jan 2018

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Malaysia
Mouth Mucosa
Stem Cell Transplantation
Epithelium
Visual Acuity
Transplants
Stem Cells
Transplantation
Chemical Burns
Rosacea
Eye Injuries
Corneal Transplantation
Eye Diseases

Keywords

  • Acne rosacea
  • Chemical injury
  • Corneal transplant
  • Cultivated oral mucosa epithelial transplantation (COMET)
  • Stevens-Johnson syndrome (SJS)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Case series of cultivated oral mucosa epithelium transplantation for limbal stem cell failure : Experience in Malaysia. / Oh, Kah Lay; Mohd Zahidin, Aida Zairani; Md Noh, Umi Kalthum; Mohd Khialdin, Safinaz; Ooi, Ghee Chien; Then, Kong Yong.

In: Asian Journal of Ophthalmology, Vol. 16, No. 2, 01.01.2018, p. 110-118.

Research output: Contribution to journalArticle

Oh, Kah Lay ; Mohd Zahidin, Aida Zairani ; Md Noh, Umi Kalthum ; Mohd Khialdin, Safinaz ; Ooi, Ghee Chien ; Then, Kong Yong. / Case series of cultivated oral mucosa epithelium transplantation for limbal stem cell failure : Experience in Malaysia. In: Asian Journal of Ophthalmology. 2018 ; Vol. 16, No. 2. pp. 110-118.
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