Case of severe refractory myasthenia gravis in HUKM

Razlan Hamizah, Norlinah Mohamed Ibrahim, Hui Jan Tan, Z. Soehardy, Abdul Halim Abdul Gafor, A. G. Rohana, B. B. Hamidon, N. C T Kong, Raymond Azman Ali

Research output: Contribution to journalArticle

Abstract

A 20-year-old girl first noticed bilateral ocular muscle weakness in 2001. Two months later, she developed acute muscle paralysis and respiratory failure which required ventilation. Serum anti-acetylcholine receptor antibodies and repetitive nerve stimulation test was positive and consistent with myasthenia gravis (MG). CT scan thorax revealed thymic enlargement and she underwent a video assisted thymectomy (VATS). However, over the next three years, despite maximal doses of various immunosuppressive agents with plasmapheresis and intravenous immunoglobulin, she was admitted with recurrent myasthenic crisis without any obvious precipitant. She was then commenced on mycophenolate mofetil and together with regular plasmapheresis, cyclosporine and prednisolone, her symptoms have finally improved and brought under control.

Original languageEnglish
Pages (from-to)633-635
Number of pages3
JournalMedical Journal of Malaysia
Volume61
Issue number5
Publication statusPublished - Dec 2006

Fingerprint

Plasmapheresis
Myasthenia Gravis
Muscle Weakness
Mycophenolic Acid
Video-Assisted Thoracic Surgery
Thymectomy
Intravenous Immunoglobulins
Cholinergic Receptors
Immunosuppressive Agents
Prednisolone
Paralysis
Respiratory Insufficiency
Cyclosporine
Ventilation
Thorax
Muscles
Antibodies
Serum

Keywords

  • Cyclosporine
  • Myasthenia gravis
  • Mycophenolate mofetil
  • Plasmapheresis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Case of severe refractory myasthenia gravis in HUKM. / Hamizah, Razlan; Mohamed Ibrahim, Norlinah; Tan, Hui Jan; Soehardy, Z.; Abdul Gafor, Abdul Halim; Rohana, A. G.; Hamidon, B. B.; Kong, N. C T; Ali, Raymond Azman.

In: Medical Journal of Malaysia, Vol. 61, No. 5, 12.2006, p. 633-635.

Research output: Contribution to journalArticle

Hamizah, R, Mohamed Ibrahim, N, Tan, HJ, Soehardy, Z, Abdul Gafor, AH, Rohana, AG, Hamidon, BB, Kong, NCT & Ali, RA 2006, 'Case of severe refractory myasthenia gravis in HUKM', Medical Journal of Malaysia, vol. 61, no. 5, pp. 633-635.
Hamizah, Razlan ; Mohamed Ibrahim, Norlinah ; Tan, Hui Jan ; Soehardy, Z. ; Abdul Gafor, Abdul Halim ; Rohana, A. G. ; Hamidon, B. B. ; Kong, N. C T ; Ali, Raymond Azman. / Case of severe refractory myasthenia gravis in HUKM. In: Medical Journal of Malaysia. 2006 ; Vol. 61, No. 5. pp. 633-635.
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