Cardiovascular risk factors and ethnicity are independent factors associated with lower urinary tract symptoms

Jasmine Lim, Nirmala Bhoo-Pathy, Selvalingam Sothilingam, Rohan Malek, Murali Sundram, Guan Hee Tan, Badrulhisham Bahadzor, Teng Aik Ong, Keng Lim Ng, Azad Hassan Abdul Razack

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: To determine the lower urinary tract symptoms (LUTS) profile and factors affecting its degree of severity including cardiovascular risk profile, age, ethnicity, education level and prostate volume in a multiethnic Asian setting. Materials and Methods: We conducted a cross-sectional study of 1021 men aged 40-79 years with no clinical evidence of prostate cancer, prostate surgery or 5α-reductase inhibitor treatment of known prostate conditions. The severity of LUTS was assessed using the International Prostate Symptom Score (IPSS). Potential factors associated with LUTS including age, ethnicity, education, history of hypertension, diabetes and hypercholesterolemia, height, weight, and prostate volume were evaluated using univariable and multivariable analyses. Results: There were 506 (50%) men found to have moderate-to-severe LUTS attaining an IPSS above 7. Overall, nocturia (45.5%) was the most frequently reported symptom. Multivariable analysis showed that age, ethnicity, prostate volume and history of hypertension and hypercholesterolemia were independent factors associated with severity of LUTS (p < 0.05). Considering individual lower urinary tract symptoms, we found a strong association of storage symptom with history of hypertension and hypercholesterolemia. Malay men were significantly bothered by post micturition symptom compared to their Chinese and Indian counterparts. Stratified analyses of LUTS demonstrated a mutually exclusive cardiovascular risk factors profile defined by ethnicity. Conclusion: Severity of LUTS varies between different ethnicities across all age groups. In addition to age and prostate volume, ethnicity and cardiovascular risk factors including hypertension and hypercholesterolemia may also need to be taken into account in managing men with LUTS.

Original languageEnglish
Article numbere0130820
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - 22 Jun 2015

Fingerprint

Lower Urinary Tract Symptoms
urinary tract
nationalities and ethnic groups
signs and symptoms (animals and humans)
risk factors
Prostate
Education
Hypercholesterolemia
Medical problems
hypercholesterolemia
Surgery
Hypertension
Oxidoreductases
hypertension
Prostatic Neoplasms
Nocturia
Urination
risk profile
Age Groups
Cross-Sectional Studies

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lim, J., Bhoo-Pathy, N., Sothilingam, S., Malek, R., Sundram, M., Tan, G. H., ... Razack, A. H. A. (2015). Cardiovascular risk factors and ethnicity are independent factors associated with lower urinary tract symptoms. PLoS One, 10(6), [e0130820]. https://doi.org/10.1371/journal.pone.0130820

Cardiovascular risk factors and ethnicity are independent factors associated with lower urinary tract symptoms. / Lim, Jasmine; Bhoo-Pathy, Nirmala; Sothilingam, Selvalingam; Malek, Rohan; Sundram, Murali; Tan, Guan Hee; Bahadzor, Badrulhisham; Ong, Teng Aik; Ng, Keng Lim; Razack, Azad Hassan Abdul.

In: PLoS One, Vol. 10, No. 6, e0130820, 22.06.2015.

Research output: Contribution to journalArticle

Lim, J, Bhoo-Pathy, N, Sothilingam, S, Malek, R, Sundram, M, Tan, GH, Bahadzor, B, Ong, TA, Ng, KL & Razack, AHA 2015, 'Cardiovascular risk factors and ethnicity are independent factors associated with lower urinary tract symptoms', PLoS One, vol. 10, no. 6, e0130820. https://doi.org/10.1371/journal.pone.0130820
Lim, Jasmine ; Bhoo-Pathy, Nirmala ; Sothilingam, Selvalingam ; Malek, Rohan ; Sundram, Murali ; Tan, Guan Hee ; Bahadzor, Badrulhisham ; Ong, Teng Aik ; Ng, Keng Lim ; Razack, Azad Hassan Abdul. / Cardiovascular risk factors and ethnicity are independent factors associated with lower urinary tract symptoms. In: PLoS One. 2015 ; Vol. 10, No. 6.
@article{afe6720dafe1421c8666aa0de5d412b5,
title = "Cardiovascular risk factors and ethnicity are independent factors associated with lower urinary tract symptoms",
abstract = "Objectives: To determine the lower urinary tract symptoms (LUTS) profile and factors affecting its degree of severity including cardiovascular risk profile, age, ethnicity, education level and prostate volume in a multiethnic Asian setting. Materials and Methods: We conducted a cross-sectional study of 1021 men aged 40-79 years with no clinical evidence of prostate cancer, prostate surgery or 5α-reductase inhibitor treatment of known prostate conditions. The severity of LUTS was assessed using the International Prostate Symptom Score (IPSS). Potential factors associated with LUTS including age, ethnicity, education, history of hypertension, diabetes and hypercholesterolemia, height, weight, and prostate volume were evaluated using univariable and multivariable analyses. Results: There were 506 (50{\%}) men found to have moderate-to-severe LUTS attaining an IPSS above 7. Overall, nocturia (45.5{\%}) was the most frequently reported symptom. Multivariable analysis showed that age, ethnicity, prostate volume and history of hypertension and hypercholesterolemia were independent factors associated with severity of LUTS (p < 0.05). Considering individual lower urinary tract symptoms, we found a strong association of storage symptom with history of hypertension and hypercholesterolemia. Malay men were significantly bothered by post micturition symptom compared to their Chinese and Indian counterparts. Stratified analyses of LUTS demonstrated a mutually exclusive cardiovascular risk factors profile defined by ethnicity. Conclusion: Severity of LUTS varies between different ethnicities across all age groups. In addition to age and prostate volume, ethnicity and cardiovascular risk factors including hypertension and hypercholesterolemia may also need to be taken into account in managing men with LUTS.",
author = "Jasmine Lim and Nirmala Bhoo-Pathy and Selvalingam Sothilingam and Rohan Malek and Murali Sundram and Tan, {Guan Hee} and Badrulhisham Bahadzor and Ong, {Teng Aik} and Ng, {Keng Lim} and Razack, {Azad Hassan Abdul}",
year = "2015",
month = "6",
day = "22",
doi = "10.1371/journal.pone.0130820",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

TY - JOUR

T1 - Cardiovascular risk factors and ethnicity are independent factors associated with lower urinary tract symptoms

AU - Lim, Jasmine

AU - Bhoo-Pathy, Nirmala

AU - Sothilingam, Selvalingam

AU - Malek, Rohan

AU - Sundram, Murali

AU - Tan, Guan Hee

AU - Bahadzor, Badrulhisham

AU - Ong, Teng Aik

AU - Ng, Keng Lim

AU - Razack, Azad Hassan Abdul

PY - 2015/6/22

Y1 - 2015/6/22

N2 - Objectives: To determine the lower urinary tract symptoms (LUTS) profile and factors affecting its degree of severity including cardiovascular risk profile, age, ethnicity, education level and prostate volume in a multiethnic Asian setting. Materials and Methods: We conducted a cross-sectional study of 1021 men aged 40-79 years with no clinical evidence of prostate cancer, prostate surgery or 5α-reductase inhibitor treatment of known prostate conditions. The severity of LUTS was assessed using the International Prostate Symptom Score (IPSS). Potential factors associated with LUTS including age, ethnicity, education, history of hypertension, diabetes and hypercholesterolemia, height, weight, and prostate volume were evaluated using univariable and multivariable analyses. Results: There were 506 (50%) men found to have moderate-to-severe LUTS attaining an IPSS above 7. Overall, nocturia (45.5%) was the most frequently reported symptom. Multivariable analysis showed that age, ethnicity, prostate volume and history of hypertension and hypercholesterolemia were independent factors associated with severity of LUTS (p < 0.05). Considering individual lower urinary tract symptoms, we found a strong association of storage symptom with history of hypertension and hypercholesterolemia. Malay men were significantly bothered by post micturition symptom compared to their Chinese and Indian counterparts. Stratified analyses of LUTS demonstrated a mutually exclusive cardiovascular risk factors profile defined by ethnicity. Conclusion: Severity of LUTS varies between different ethnicities across all age groups. In addition to age and prostate volume, ethnicity and cardiovascular risk factors including hypertension and hypercholesterolemia may also need to be taken into account in managing men with LUTS.

AB - Objectives: To determine the lower urinary tract symptoms (LUTS) profile and factors affecting its degree of severity including cardiovascular risk profile, age, ethnicity, education level and prostate volume in a multiethnic Asian setting. Materials and Methods: We conducted a cross-sectional study of 1021 men aged 40-79 years with no clinical evidence of prostate cancer, prostate surgery or 5α-reductase inhibitor treatment of known prostate conditions. The severity of LUTS was assessed using the International Prostate Symptom Score (IPSS). Potential factors associated with LUTS including age, ethnicity, education, history of hypertension, diabetes and hypercholesterolemia, height, weight, and prostate volume were evaluated using univariable and multivariable analyses. Results: There were 506 (50%) men found to have moderate-to-severe LUTS attaining an IPSS above 7. Overall, nocturia (45.5%) was the most frequently reported symptom. Multivariable analysis showed that age, ethnicity, prostate volume and history of hypertension and hypercholesterolemia were independent factors associated with severity of LUTS (p < 0.05). Considering individual lower urinary tract symptoms, we found a strong association of storage symptom with history of hypertension and hypercholesterolemia. Malay men were significantly bothered by post micturition symptom compared to their Chinese and Indian counterparts. Stratified analyses of LUTS demonstrated a mutually exclusive cardiovascular risk factors profile defined by ethnicity. Conclusion: Severity of LUTS varies between different ethnicities across all age groups. In addition to age and prostate volume, ethnicity and cardiovascular risk factors including hypertension and hypercholesterolemia may also need to be taken into account in managing men with LUTS.

UR - http://www.scopus.com/inward/record.url?scp=84939136156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939136156&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0130820

DO - 10.1371/journal.pone.0130820

M3 - Article

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 6

M1 - e0130820

ER -