Cardioprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats

Kamisah Yusof, Vengadesh Periyah, Kee Tat Lee, Norrashid Noor-Izwan, Amran Nurul-Hamizah, Badlishah Sham Nurul-Iman, Kogilavani Subermaniam, Kamsiah Jaarin, Azman Abdullah, Faizah Othman, Qodriyah Mohd Saad

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Context: Virgin coconut oil (VCO) contains high antioxidant activity which may have protective effects on the heart in hypertensive rats. Objectives: The study investigated the effects of VCO on blood pressure and cardiac tissue by measuring angiotensin-converting enzyme (ACE) activity and its histomorphometry in rats fed with a heated palm oil (HPO) diet. Materials and methods: Thirty-two male Sprague-Dawley rats were randomly divided into four groups: (i) control, (ii) orally given VCO (1.42ml/kg), (iii) fed with a HPO (15%) diet, and (iv) fed with a HPO diet and supplemented with VCO (1.42ml/kg, po) (HPO+VCO) for 16 weeks. Blood pressure was measured monthly. After 16 weeks, rat hearts were dissected for lipid peroxidation (TBARS) and ACE activity measurement and histomorphometric study. Results: Systolic blood pressure was significantly increased in the HPO group compared with the control starting at week eight (112.91±1.32 versus 98.08±3.61mmHg, p

Original languageEnglish
Pages (from-to)1243-1249
Number of pages7
JournalPharmaceutical Biology
Volume53
Issue number9
DOIs
Publication statusPublished - 2015

Fingerprint

Diet
Blood Pressure
Peptidyl-Dipeptidase A
Lipid Peroxidation
Sprague Dawley Rats
Antioxidants
coconut oil
palm oil
Control Groups

Keywords

  • Angiotensin-converting enzyme
  • heart
  • hypertension
  • myofiber area
  • myofiber width
  • oxidative stress

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Molecular Medicine

Cite this

Cardioprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats. / Yusof, Kamisah; Periyah, Vengadesh; Lee, Kee Tat; Noor-Izwan, Norrashid; Nurul-Hamizah, Amran; Nurul-Iman, Badlishah Sham; Subermaniam, Kogilavani; Jaarin, Kamsiah; Abdullah, Azman; Othman, Faizah; Mohd Saad, Qodriyah.

In: Pharmaceutical Biology, Vol. 53, No. 9, 2015, p. 1243-1249.

Research output: Contribution to journalArticle

Yusof, Kamisah ; Periyah, Vengadesh ; Lee, Kee Tat ; Noor-Izwan, Norrashid ; Nurul-Hamizah, Amran ; Nurul-Iman, Badlishah Sham ; Subermaniam, Kogilavani ; Jaarin, Kamsiah ; Abdullah, Azman ; Othman, Faizah ; Mohd Saad, Qodriyah. / Cardioprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats. In: Pharmaceutical Biology. 2015 ; Vol. 53, No. 9. pp. 1243-1249.
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