Cardiac nuclear imaging: Current status and future directions

Zhonghua Sun, Aini Ab. Aziz, Ahmad Khairuddin Md Yusof

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Cardiac single photon emission computed tomography (SPECT) and positron emission tomography (PET) are increasingly being used in the evaluation of patients with suspected or known coronary artery disease by assessing myocardial viability and perfusion and providing invaluable diagnostic and prognostic information. With their capacity to quantify left ventricular function as well as coronary flow reserve, these myocardial perfusion imaging techniques are superior to other methods for the detection of multivessel coronary artery disease and potentially, for risk stratification and prediction of cardiac events. Hybrid SPECT/CT and PET/CT scanners allow identification of flow-limiting coronary lesions and therefore offering great potential for both diagnosis and management. Advances in molecular biology of the cardiovascular system have helped to develop the molecular imaging which may be useful to evaluate targeted molecular and cellular abnormalities in the future. In this review, we will discuss the current state of the art in cardiac nuclear imaging, which include SPECT and PET evaluation of myocardial viability and perfusion. Radiopharmaceuticals used in cardiac SPECT and PET imaging are described, and radiation dose associated with the radiopharmaceuticals is briefly discussed. Clinical applications of hybrid imaging methods in coronary artery disease are presented and future directions are highlighted.

    Original languageEnglish
    Pages (from-to)170-183
    Number of pages14
    JournalCurrent Medical Imaging Reviews
    Volume9
    Issue number3
    DOIs
    Publication statusPublished - Aug 2013

    Fingerprint

    Single-Photon Emission-Computed Tomography
    Positron-Emission Tomography
    Coronary Artery Disease
    Radiopharmaceuticals
    Perfusion
    Multimodal Imaging
    Myocardial Perfusion Imaging
    Molecular Imaging
    Cardiovascular System
    Left Ventricular Function
    Molecular Biology
    Radiation
    Direction compound

    Keywords

    • Coronary artery disease
    • Myocardial perfusion imaging
    • Positron emission tomography
    • Radiopharmaceuticals
    • Single photon emission computed tomography

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Cardiac nuclear imaging : Current status and future directions. / Sun, Zhonghua; Ab. Aziz, Aini; Md Yusof, Ahmad Khairuddin.

    In: Current Medical Imaging Reviews, Vol. 9, No. 3, 08.2013, p. 170-183.

    Research output: Contribution to journalArticle

    Sun, Zhonghua ; Ab. Aziz, Aini ; Md Yusof, Ahmad Khairuddin. / Cardiac nuclear imaging : Current status and future directions. In: Current Medical Imaging Reviews. 2013 ; Vol. 9, No. 3. pp. 170-183.
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